Significance of Lymphatic Invasion on Regional Lymph Node Metastasis in Early Gastric Cancer Using LYVE-1 Immunohistochemical Analysis

Introduction Gastric cancer is the fourth most common cancer in the world. By the time the patients are diagnosed with stage IV gastric cancer, many patients already have distant metastases. There is no unified systemic treatment plan in existence. The use of gastrectomy is ambiguous in patients with stage IV gastric cancer. The objective of this study was to evaluate the beneficial outcome of gastrectomy in patients with stage IV gastric cancer. Methods Clinical information of patients with gastric cancer from 2000 to 2010 in the Surveillance, Epidemiology, and End Results database were extracted and analysed. The risk factors for stage IV gastric cancer were also analysed. Results We observed that the median survival time for patients after surgery was greater than that for patients not treated surgically. The five-year survival rate for chemotherapy patients was higher than that of non-chemotherapeutic patients. Patients who receive both chemotherapy and surgery could achieve a more significant survival benefit. The risks following gastrectomy (partial, subtotal, hemi-) were lower than those of other surgical procedures, which provided guidance on the choice of surgical method. The numbers of regional lymph node metastasis were found to be related to prognosis. Conclusions In patients with stage IV gastric cancer, gastrectomy (partial, subtotal or hemi) should be selected when surgery is necessary. The number of regional lymph node metastasis could be considered as a prognostic factor for patients with stage IV gastric cancer and lymph node dissection could reduce the risk of patients undergoing surgery.

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Histopathological predictor for regional lymph node metastasis in gastric cancer

Virchows Archiv ◽

10.1007/s00428-008-0717-3 ◽

2008 ◽

Vol 454 (2) ◽

pp. 143-151 ◽

Cited By ~ 7

Author(s):

Hiroshi Morita ◽

Yukio Ishikawa ◽

Yuri Akishima-Fukasawa ◽

Kinji Ito ◽

Yoshikiyo Akasaka ◽

...

Keyword(s):

Gastric Cancer ◽

Lymph Node ◽

Lymph Node Metastasis ◽

Regional Lymph Node ◽

Regional Lymph Node Metastasis ◽

Node Metastasis

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Synergistic Effect of Lymphatic Invasion and Venous Invasion on the Risk of Lymph Node Metastasis in Patients with Non-Curative Endoscopic Resection of Early Gastric Cancer

Journal of Gastrointestinal Surgery ◽

10.1007/s11605-019-04302-0 ◽

2019 ◽

Vol 24 (7) ◽

pp. 1499-1509

Author(s):

Hye Jin Kang ◽

Hyunsoo Chung ◽

Sang Gyun Kim ◽

Jung Kim ◽

Jue Lie Kim ◽

...

Keyword(s):

Gastric Cancer ◽

Lymph Node ◽

Lymph Node Metastasis ◽

Early Gastric Cancer ◽

Synergistic Effect ◽

Endoscopic Resection ◽

Venous Invasion ◽

Lymphatic Invasion ◽

Node Metastasis

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Clinicopathological Features Associated with Lymph Node Metastasis in Early Gastric Cancer: Analysis of a Single-Institution Experience in China

Canadian Journal of Gastroenterology ◽

10.1155/2009/462678 ◽

2009 ◽

Vol 23 (5) ◽

pp. 353-356 ◽

Cited By ~ 27

Author(s):

Lizong Shen ◽

Yiming Huang ◽

Maocai Sun ◽

Hao Xu ◽

Wei Wei ◽

...

Keyword(s):

Gastric Cancer ◽

Lymph Node ◽

Lymph Node Metastasis ◽

Early Gastric Cancer ◽

Gastric Carcinoma ◽

Tumour Size ◽

Lymphatic Invasion ◽

Histological Classification ◽

Node Metastasis ◽

Macroscopic Type

BACKGROUND: An accurate assessment of potential lymph node metastasis is an important issue for the appropriate treatment of early gastric cancer. Minimizing the number of invasive procedures used in cancer therapy is critical for improving the patient’s quality of life.OBJECTIVE: To evaluate the clinicopathological features associated with lymph node metastasis of early gastric cancer in patients from a single institution in China.METHODS: A retrospective review of data from 410 patients surgically treated for early gastric cancer at the First Affiliated Hospital (Nanjing, China) between 1998 and 2007, was conducted. The clinicopathological variables associated with lymph node metastasis were evaluated.RESULTS: Lymph node metastasis was observed in 12.20% of patients. The macroscopic type, tumour size, location in the stomach, depth of gastric carcinoma infiltration, and presence of vascular or lymphatic invasion showed a positive correlation with the incidence of lymph node metastasis by univariate analysis. Multivariate analyses revealed histological classification, macroscopic type, tumour size, depth of gastric carcinoma infiltration, and the presence of vascular or lymphatic invasion to be significantly and independently related to lymph node metastasis. The depth of gastric carcinoma infiltration was the strongest predictive factor for lymph node metastasis. For intramucosal cancer, tumour size was the unique risk factor for lymph node metastasis. For submucosal cancer, histological classification and tumour size were independent risk factors for lymph node metastasis.CONCLUSIONS: Histological classification, macroscopic type, tumour size, depth of gastric carcinoma infiltration, and the presence of vascular or lymphatic invasion are independent risk factors for lymph node metastasis in patients with early gastric cancer in China. Minimal invasive treatment, such as endoscopic mucosal resection, may be possible for highly selected cancers.

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