scholarly journals Amniotic membrane transplantation for infectious corneal ulcer treatment: a cohort retrospective study

2020 ◽  
Vol 29 (4) ◽  
pp. 379-85
Author(s):  
Vega Casalita ◽  
Rina La Distia Nora ◽  
Lukman Edwar ◽  
Made Susiyanti ◽  
Ratna Sitompul
Keyword(s):  
Amniotic Membrane ◽  
Corneal Ulcer ◽  
Treatment Success ◽  
Healing Time ◽  
Complete Healing ◽  
Amniotic Membrane Transplantation ◽  
Corneal Wound ◽  
Uncorrected Visual Acuity ◽  
Snellen Chart ◽  
Corneal Scar

BACKGROUND Corneal ulcer is one of the most common causes of corneal blindness. This study aimed to describe the outcomes of amniotic membrane transplantation (AMT) in patients with infectious corneal ulcer. METHODS A retrospective cohort study based on medical records of patients who underwent an adjuvant AMT procedure over a 2-year period (2015–2017) was conducted at Cipto Mangunkusumo Hospital Jakarta. Uncorrected visual acuity (UCVA) was measured with the Snellen chart. Treatment success was marked by complete healing (disappearance of corneal infiltrates, epithelial defect closure, and corneal scar formation). Healing time was the duration from AMT surgery to complete healing. RESULTS 50 cases of infectious corneal ulcer, 12 of which had perforation were included. Gram-positive cocci (18%), gram-negative rods (14%), fungi (4%), and Acanthamoeba (2%) were isolated from culture specimens. Successful results were observed in 90% of cases (20/21 moderate cases and 25/29 severe cases). Healing time was 21 (14–63) days in moderate cases and 28 (14–90) days in severe cases. Baseline UCVA improved from 2.48 (0.22–2.80) logMAR to 1.30 (0–2.80) logMAR within 3–4 weeks postoperatively and to 0.94 (0–2.80) logMAR at the last follow-up. Post-AMT complications included recurrent perforation in 4 eyes, persistent epithelial defects in 2 eyes, amniotic membrane infection in 1 eye, and membrane retraction in 1 eye. CONCLUSIONS AMT was successfully used to treat moderate and severe infectious corneal ulcer, particularly in nonresponsive and some perforated cases. AMT provides biochemical and mechanical support for corneal wound healing with good visual outcomes.

scholarly journals Active Pedicle Epithelial Flap Transposition Combined with Amniotic Membrane Transplantation for Treatment of Nonhealing Corneal Ulcers

2016 ◽  
Vol 2016 ◽  
pp. 1-7
Author(s):  
Ting Zhang ◽  
Yuexin Wang ◽  
Yanni Jia ◽  
Dongle Liu ◽  
Suxia Li ◽  
...  
Keyword(s):  
Confocal Microscopy ◽  
Amniotic Membrane ◽  
Ulcer Healing ◽  
Laser Scanning ◽  
Corneal Ulcer ◽  
Anterior Segment ◽  
Healing Time ◽  
Stevens Johnson Syndrome ◽  
Amniotic Membrane Transplantation ◽  
Corneal Ulcers

Introduction. The objective was to evaluate the efficacy of active pedicle epithelial flap transposition combined with amniotic membrane transplantation (AMT) in treating nonhealing corneal ulcers.Material and Methods. Eleven patients (11 eyes) with nonhealing corneal ulcer who underwent the combined surgery were included. Postoperatively, ulcer healing time was detected by corneal fluorescein staining. Visual acuity, intraocular pressure, surgical complications, and recurrence were recorded. Corneal status was inspected by the laser scanning confocal microscopy and anterior segment optical coherence tomography (AS-OCT).Results. The primary diseases were herpes simplex keratitis (8 eyes), corneal graft ulcer (2 eyes), and Stevens-Johnson syndrome (1 eye). All epithelial flaps were intact following surgery, without shedding or displacement. Mean ulcer healing time was10.8±3.1days, with a healing rate of 91%. Vision significantly improved from 1.70 to 0.82 log MAR (P=0.001). A significant decrease in inflammatory cell infiltration and corneal stromal edema was revealed 2 months postoperatively by confocal microscopy and AS-OCT. Corneal ulcer recurred in 1 eye. None of the patients developed major complications.Conclusion. Active pedicle epithelial flap transposition combined with AMT is a simple and effective treatment for nonhealing corneal ulcers.

Sutureless “Contact Lens Sandwich” Technique for Amniotic Membrane Therapy of Central Corneal Ulcers

2021 ◽  
pp. 112067212110490
Author(s):  
Saverio V. Luccarelli ◽  
Edoardo Villani ◽  
Stefano Lucentini ◽  
Francesco Bonsignore ◽  
Matteo Sacchi ◽  
...  
Keyword(s):  
Amniotic Membrane ◽  
Contact Lens ◽  
Low Cost ◽  
Healing Time ◽  
Amniotic Membrane Transplantation ◽  
Recurrence Rates ◽  
Sandwich Technique ◽  
Corneal Ulcers ◽  
Bandage Contact Lens ◽  
Ring Complex

Purpose To describe a new technique for sutureless and glue-free amniotic membrane transplantation (AMT) and to investigate its effectiveness to treat corneal persistent epithelial defects (PEDs), compared to bandage contact lens (BCL) application alone. Methods We performed AMT with “contact lens sandwich technique” (CLS-AMT) in 8 consecutive patients with central/para-central (up to 4.00 mm from the geometrical centre) PED/ulceration and we retrospectively compared the results with 11 BCL procedures. Results The procedures were performed successfully with no complications. CLS-AMT showed significantly shorter healing time than BCL (24.0  ±  19.1 vs 42.9  ±  14.6 days; P < 0.05, Mann-Whitney test). Recurrence rates were 12% and 27% for CLS-AMT and BCL, respectively. Conclusion CLS-AMT technique, based on the suction effect due to the superposition of a bandage contact lens on the AM-ring complex, represents a quick, low cost, easy to perform and nearly non-invasive AMT technique. This approach is able to provide adequate fixation of AM, and it seems to be a safe and effective treatment for patients with PEDs.

Amniotic Membrane Transplantation in Infectious Corneal Ulcer

Cornea ◽  
2001 ◽  
Vol 20 (7) ◽  
pp. 720-726 ◽  
Author(s):  
Jae-Soon Kim ◽  
Jae-Chan Kim ◽  
Tae-Won Hahn ◽  
Woo-Chan Park
Keyword(s):  
Amniotic Membrane ◽  
Corneal Ulcer ◽  
Amniotic Membrane Transplantation

Amniotic membrane transplantation (AMT): Implications for corneal wound healing

2008 ◽  
Vol 86 ◽  
pp. 0-0
Author(s):  
DG SAID ◽  
M NUBILE ◽  
A HOPKINSON ◽  
T GRAY ◽  
J LOWE ◽  
...  
Keyword(s):  
Wound Healing ◽  
Amniotic Membrane ◽  
Amniotic Membrane Transplantation ◽  
Corneal Wound Healing ◽  
Corneal Wound

scholarly journals Erratum: Amniotic membrane transplantation for infectious corneal ulcer treatment: a cohort retrospective study

2021 ◽  
Vol 30 (1) ◽  
pp. 86
Author(s):  
Vega Casalita ◽  
Rina La Distia Nora ◽  
Lukman Edwar ◽  
Made Susiyanti ◽  
Ratna Sitompul
Keyword(s):  
Retrospective Study ◽  
Amniotic Membrane ◽  
Corneal Ulcer ◽  
Amniotic Membrane Transplantation ◽  
Ulcer Treatment

[This corrects the article DOI: 10.13181/mji.oa.203849]

scholarly journals A Challenging Management of Pseudomonas Perforated Corneal Ulcer with Multilayer Amniotic Membrane Transplantation and Pericardial Patch Graft in Pediatric Patient

2021 ◽  
Vol 1 (1) ◽  
pp. 22
Author(s):  
Nabilah Afifah ◽  
Herwindo Dicky Putranto ◽  
Lely Retno Wulandari
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Amniotic Membrane ◽  
Corneal Ulcer ◽  
Definitive Treatment ◽  
Amniotic Membrane Transplantation ◽  
Pericardial Patch ◽  
Corneal Perforation ◽  
Corneal Ulcers ◽  
Patch Graft ◽  
The Right

Introduction: Pseudomonas aeruginosa (P. aeruginosa) is the leading cause of corneal ulcers in children 0 to 3 years of age compared to children in general. Case presentation: A two-months-old infant presented with whitish patches on the right eye two days before admission. A central corneal ulcer with a size of 7-mm x 7-mm accompanied by corneal thinning and melting was shown on the right cornea. It is was surrounded by greyish white creamy infiltrates. Corneal scraping showed Pseudomonas aeruginosa specimens. The cornea became perforate and crystalline lens extrusion was found at the day after intravenous ceftriaxone, levofloxacin eye drop, and cefazoline fortified eye drop administering. It might be caused by bacterial elastase and toxin which contributed to corneal damage. The patient was underwent a multilayer Amniotic Membrane Transplantation (AMT) combined with a pericardial patch graft due to corneal perforation. Two months post-AMT and pericardial patch graft the corneal perforation became entirely heal due to multilayer AMT, despite lysis of the pericardial patch graft. Corneal scar formation and reduction of vitreous opacity in ultrasound examination were shown. The patient was planned to undergo keratoplasty. Conclusions: Corneal ulcers due to Pseudomonas aeruginosa are highly destructive. The levels of infection, diagnostic, and therapeutic are still problems in pediatric patients. Lens extrusion and lysis of the pericardial patch graft are examples in this case. Keratoplasty is the definitive treatment for corneal ulcers with perforation; however, multilayer AMT combined with pericardial patch graft can be used as an alternative therapy to accelerate wound healing, reduce inflammation, and maintain the integrity of the eyeball.

Effect of Human Amniotic Membrane Transplantation in Reconstruction of Canine Corneal Wound

2019 ◽  
Vol 60 (2) ◽  
pp. 56
Author(s):  
Ahmed Korittum ◽  
Mostafa Kassem ◽  
Aya Adel ◽  
Alaa Gaith ◽  
Nagwan Habashi
Keyword(s):  
Amniotic Membrane ◽  
Amniotic Membrane Transplantation ◽  
Human Amniotic Membrane ◽  
Corneal Wound
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