Evaluation of alternative methods for radiochemical purity testing of indium-111 capromab pendetide

2011 ◽  
Vol 51 (3) ◽  
pp. 359-362 ◽  
Author(s):  
James A. Ponto
Keyword(s):  
Radiochemical Purity ◽  
Alternative Methods ◽  
Purity Testing ◽  
Indium 111

scholarly journals Preliminary Study of a 1,5-Benzodiazepine-Derivative Labelled with Indium-111 for CCK-2 Receptor Targeting

Molecules ◽  
2021 ◽  
Vol 26 (4) ◽  
pp. 918
Author(s):  
Marco Verona ◽  
Sara Rubagotti ◽  
Stefania Croci ◽  
Sophia Sarpaki ◽  
Francesca Borgna ◽  
...  
Keyword(s):  
Radiochemical Purity ◽  
Single Photon ◽  
Photon Emission ◽  
Tumor Cell Line ◽  
Normal Tissues ◽  
Molar Activity ◽  
Suitable Target ◽  
Indium 111 ◽  
Preliminary Study

The cholecystokinin-2 receptor (CCK-2R) is overexpressed in several human cancers but displays limited expression in normal tissues. For this reason, it is a suitable target for developing specific radiotracers. In this study, a nastorazepide-based ligand functionalized with a 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) chelator (IP-001) was synthesized and labelled with indium-111. The radiolabeling process yielded >95% with a molar activity of 10 MBq/nmol and a radiochemical purity of >98%. Stability studies have shown a remarkable resistance to degradation (>93%) within 120 h of incubation in human blood. The in vitro uptake of [111In]In-IP-001 was assessed for up to 24 h on a high CCK-2R-expressing tumor cell line (A549) showing maximal accumulation after 4 h of incubation. Biodistribution and single photon emission tomography (SPECT)/CT imaging were evaluated on BALB/c nude mice bearing A549 xenograft tumors. Implanted tumors could be clearly visualized after only 4 h post injection (2.36 ± 0.26% ID/cc), although a high amount of radiotracer was also found in the liver, kidneys, and spleen (8.25 ± 2.21%, 6.99 ± 0.97%, and 3.88 ± 0.36% ID/cc, respectively). Clearance was slow by both hepatobiliary and renal excretion. Tumor retention persisted for up to 24 h, with the tumor to organs ratio increasing over-time and ending with a tumor uptake (1.52 ± 0.71% ID/cc) comparable to liver and kidneys.

99Tcm-MAG3: Problems with radiochemical purity testing

2000 ◽  
Vol 21 (1) ◽  
pp. 71-75 ◽  
Author(s):  
T MURRAY ◽  
K McKELLAR ◽  
J OWENS ◽  
W S WATSON ◽  
T E HILDITCH ◽  
...  
Keyword(s):  
Radiochemical Purity ◽  
Purity Testing

scholarly journals A Rapid Radiochemical Purity Testing Method for 99mTc-Tetrofosmin

2010 ◽  
Vol 38 (2) ◽  
pp. 81-84 ◽  
Author(s):  
L. A. Eggert ◽  
M. D. Dick ◽  
D. W. Mahoney ◽  
J. P. Olson ◽  
G. L. Werner ◽  
...  
Keyword(s):  
Radiochemical Purity ◽  
Testing Method ◽  
99Mtc Tetrofosmin ◽  
Purity Testing

99Tcm-MAG3: Problems with radiochemical purity testing

2001 ◽  
Vol 22 (1) ◽  
pp. 114-115 ◽  
Author(s):  
G. J. Ensing ◽  
H. H. Knight
Keyword(s):  
Radiochemical Purity ◽  
Purity Testing

Comparison of different methods for radiochemical purity testing of [99mTc-EDDA-HYNIC-D-Phe1,Tyr3]-Octreotide

2006 ◽  
Vol 64 (2) ◽  
pp. 194-200 ◽  
Author(s):  
Elisabeth von Guggenberg ◽  
Barbara Penz ◽  
Georg Kemmler ◽  
Irene Virgolini ◽  
Clemens Decristoforo
Keyword(s):  
Radiochemical Purity ◽  
Purity Testing

Comparison of four alternative radiochemical purity testing methods for 99Tcm-sestamibi

1995 ◽  
Vol 16 (2) ◽  
pp. 99-104 ◽  
Author(s):  
J. C. HUNG ◽  
M. E. WILSON ◽  
M. W. GEBHARD ◽  
R. J. GIBBONS
Keyword(s):  
Radiochemical Purity ◽  
Testing Methods ◽  
Purity Testing

scholarly journals Evaluation of different counting methods for use in radiochemical purity testing procedures for 99mTc-labelled radiopharmaceuticals

2008 ◽  
Vol 66 (4) ◽  
pp. 556-559 ◽  
Author(s):  
Claudio Maioli ◽  
Alberto Bestetti ◽  
Franco Milani ◽  
Gian Paolo Cornalba ◽  
Luca Tagliabue ◽  
...  
Keyword(s):  
Radiochemical Purity ◽  
Testing Procedures ◽  
Purity Testing ◽  
Counting Methods
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