Oxacycle synthesis via radical cyclization of β-alkoxyacrylates

2005 ◽  
Vol 77 (12) ◽  
pp. 2073-2081 ◽  
Author(s):  
Eun Lee
Keyword(s):  
Natural Products ◽  
Radical Cyclization ◽  
Cyclization Reaction

Oxolane and oxane units in oxacyclic natural products were prepared via radical cyclization reaction of β-alkoxyacrylates, β-alkoxymethacrylates, and β-alkoxyvinyl ketones.

Rapid construction of the 6/6/5 tricyclic framework via a tandem radical cyclization reaction and its application to the synthesis of 5-epi-7-deoxy-isoabietenin A

2017 ◽  
Vol 4 (11) ◽  
pp. 2211-2215 ◽  
Author(s):  
Hao Zhang ◽  
Shiqiang Ma ◽  
Zhimin Xing ◽  
Lin Liu ◽  
Bowen Fang ◽  
...  
Keyword(s):  
Natural Products ◽  
Radical Cyclization ◽  
Cyclization Reaction ◽  
Rapid Construction

A tandem radical cyclization towards the 6/6/5 tricyclic skeleton, which exists in numerous natural products, was developed in modest to good yields.

Regioselective Synthesis of 2,3‐Dihydrobenzo[ f ]isoindolones via Ag‐Catalyzed Sequential Ugi 4CR/Cascade Radical Cyclization Reaction

2021 ◽  
Vol 363 (4) ◽  
pp. 1038-1043
Author(s):  
Ying‐Chun He ◽  
Yan‐Mei Yan ◽  
Zhen‐Xing Ren ◽  
Yong‐Zhao Wang ◽  
Qiang Yu ◽  
...  
Keyword(s):  
Radical Cyclization ◽  
Cyclization Reaction ◽  
Regioselective Synthesis

scholarly journals Expedient Access to Enantiopure Cyclopentanic Natural Products: Total Synthesis of (-)-Cyclonerodiol

2015 ◽  
Vol 10 (1) ◽  
pp. 1934578X1501000
Author(s):  
Carmen Pérez Morales ◽  
M. Mar Herrador ◽  
José F. Quílez del Moral ◽  
Alejandro F. Barrero
Keyword(s):  
Natural Products ◽  
Total Synthesis ◽  
Radical Cyclization ◽  
Formal Synthesis ◽  
Common Precursor ◽  
Enantiospecific Synthesis ◽  
Optically Pure

Following the principles of collective total synthesis, a number of natural products sharing an optically pure, multifunctional, cyclopentanic core were synthesized from a common precursor: plinol A (1). This intermediate was efficiently obtained in only four steps from (-)-linalool (2) using as the key step a Ti(III)-mediated diastereoselective radical cyclization. The feasibility of this approach was confirmed with the expedient enantiospecific synthesis of cyclonerodiol (3), and the formal synthesis of chocol G (4) and piperitone (5).

ChemInform Abstract: Novel Synthesis and Functionalization of ortho-ortho Disubstituted Biphenyls and a Highly Condensed Novel Heterocycle Using Radical Cyclization Reaction.

ChemInform ◽  
2013 ◽  
Vol 44 (15) ◽  
pp. no-no
Author(s):  
C. H. Wang ◽  
A. R. White ◽  
S. N. Schwartz ◽  
S. Alluri ◽  
T. M. Cattabiani ◽  
...  
Keyword(s):  
Radical Cyclization ◽  
Cyclization Reaction ◽  
Novel Synthesis
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