Executive Functioning Mediates the Effect of Behavioral Problems on Depression in Mothers of Children With Developmental Disabilities

Abstract The present investigation explored long-term relationships of behavioral symptoms of adolescents and adults with developmental disabilities with the mental health of their mothers. Fragile X premutation carrier mothers of an adolescent or adult child with fragile X syndrome (n = 95), and mothers of a grown child with autism (n = 213) were included. Behavioral symptoms at Time 1 were hypothesized to predict maternal depressive symptoms at Time 3 via maternal executive dysfunction at Time 2. Results provided support for the mediating pathway of executive dysfunction. Additionally, the association of behavioral symptoms with executive dysfunction differed across the two groups, suggesting that premutation carriers may be more susceptible to caregiving stress due to their genotype.

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Focal areas of a high rate of fragile X in Indonesia: a long term follow up

Journal of Biomedicine and Translational Research ◽

10.14710/jbtr.v5i2.6895 ◽

2019 ◽

Vol 5 (2) ◽

pp. 67-68

Author(s):

Sultana MH Faradz ◽

Tri Indah Winarni

Keyword(s):

Mental Retardation ◽

Behavioral Problems ◽

Fragile X ◽

Autism Spectrum ◽

High Rate ◽

Learning Ability ◽

Fragile X Mental Retardation ◽

Cgg Repeats ◽

Long Term Follow Up

Fragile X syndrome (FXS) is the most common cause of inherited intellectual disability (ID) and a leading cause of autism spectrum disorder (ASD). FXS is caused by an expansion of CGG repeats >200 in the 5′ untranslated region of the promotor region fragile X mental retardation 1 gene (FMR1), which is located on Xq27.3. The abnormal CGG expansion leads to methylation and transcriptional silencing of the FMR1 gene, resulting in a reduction or loss of fragile X mental retardation 1 protein (FMRP) and causes long, thin, and immature dendritic spines, which lead to deficits in cognitive function, behavioral problems, and learning ability

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Perspectives of a Clinical Trials Research Nurse

International Psychogeriatrics ◽

10.1017/s1041610297003864 ◽

1997 ◽

Vol 8 (S3) ◽

pp. 465-468 ◽

Cited By ~ 3

Author(s):

Carolyn York Cooler

Keyword(s):

Behavioral Problems ◽

Adult Child ◽

Well Being ◽

Community Settings ◽

Behavioral Disturbances ◽

Term Care ◽

Care Facilities ◽

Considerable Impact

In both the nursing home and community settings, behavioral disturbances of dementia have a considerable impact on caregivers. In long-term care facilities, behavioral problems impede the ability of nursing staff to perform their duties and affect their sense of job satisfaction. In the community, where persons with dementia typically are cared for by a spouse or adult child, behavioral problems affect the quality of life and sense of well-being of the caregiver. The overwhelming stress and feelings of burden engendered by behavioral disturbances often lead family caregivers to place patients in nursing homes.

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Long term verbal memory recall deficits in fragile X premutation females

Neurobiology of Learning and Memory ◽

10.1016/j.nlm.2017.07.002 ◽

2017 ◽

Vol 144 ◽

pp. 131-135 ◽

Cited By ~ 1

Author(s):

Annie L Shelton ◽

Kim Cornish ◽

Joanne Fielding

Keyword(s):

Verbal Memory ◽

Fragile X ◽

Memory Recall ◽

Fragile X Premutation

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Brain structure and intragenic DNA methylation are correlated, and predict executive dysfunction in fragile X premutation females

Translational Psychiatry ◽

10.1038/tp.2016.250 ◽

2016 ◽

Vol 6 (12) ◽

pp. e984-e984 ◽

Cited By ~ 10

Author(s):

A L Shelton ◽

K M Cornish ◽

S Kolbe ◽

M Clough ◽

H R Slater ◽

...

Keyword(s):

Dna Methylation ◽

Brain Structure ◽

Fragile X ◽

Executive Dysfunction ◽

Fragile X Premutation

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Review of Programs for Persons Facing Death with Dementia

Healthcare ◽

10.3390/healthcare7020062 ◽

2019 ◽

Vol 7 (2) ◽

pp. 62 ◽

Cited By ~ 2

Author(s):

Ladislav Volicer

Keyword(s):

Quality Of Life ◽

Behavioral Problems ◽

Sensory Deprivation ◽

Executive Dysfunction ◽

Behavioral Symptoms ◽

Advanced Dementia ◽

Functional Impairments ◽

People With Dementia ◽

Quality Life

Background: Persons with advanced dementia cannot initiate activities because of the executive dysfunction. The lack of activities was identified as one of the most important factors contributing to behavioral problems of these persons. The unmet needs were boredom/sensory deprivation, loneliness/need for social interaction, and need for meaningful activities. There is a need for activities designed specifically for residents with advanced dementia. Objective: A description of patient’s needs and of programs that intend to maintain quality of life for people with dementia and facing death. Data sources: A literature review of programs used for persons with advanced dementia and residing in long-term facilities, using the PubMed data base and collateral sources. Results: Since palliative care is appropriate for persons with advanced dementia, attention has to be paid to three following important aspects of care: Medical issues, behavioral symptoms, and meaningful activities. Medical interventions should be limited to those which have more benefits than burdens, behavioral symptoms should be distinguished according to the context in which they occur, and treated by non-pharmacological interventions that involve meaningful activities. This review describes four programs that may promote the quality of life in persons with advanced dementia and facing death. They are designed for persons with advanced dementia, taking into account their functional impairments. Most of these programs involve short infrequent sessions. In contrast, Namaste Care is a daily extended program of enhanced nursing care that can provide quality of life until the last breath. Conclusions: It is possible to maintain quality life for people with advanced dementia if a special program of activities is available.

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