In Romans 7:24, Paul utters a cry that has echoed down the centuries: “O wretched man that I am! Who shall deliver me from the body of this death?” Paul’s moving outcry attracted the sustained attention of poets in early modern England, among them Spenser, Donne, and Milton, not only because of Paul’s anguish but also because of his unusual phrasing and figuration. The Bible carefully specifies “this death,” which suggests that the death at issue is spiritual and that it results from sin, not simply from the physical constitution of humankind. Yet physical death is implicit in the Adamic sin that human beings inherit and is thus embedded in their fallen nature. Donne’s sermons, Spenser’s Maleger, and Milton’s figures of Sin and Death explore the inextricability of spirit and flesh in the body that is this death.