scholarly journals An Autism-Associated Variant of Epac2 Reveals a Role for Ras/Epac2 Signaling in Controlling Basal Dendrite Maintenance in Mice

PLoS Biology ◽  
2012 ◽  
Vol 10 (6) ◽  
pp. e1001350 ◽  
Author(s):  
Deepak P. Srivastava ◽  
Kevin M. Woolfrey ◽  
Kelly A. Jones ◽  
Charles T. Anderson ◽  
Katharine R. Smith ◽  
...  
Keyword(s):  
Basal Dendrite

scholarly journals Local glutamate-mediated dendritic plateau potentials change the state of the cortical pyramidal neuron

2021 ◽  
Vol 125 (1) ◽  
pp. 23-42
Author(s):  
Peng P. Gao ◽  
Joseph W. Graham ◽  
Wen-Liang Zhou ◽  
Jinyoung Jang ◽  
Sergio Angulo ◽  
...  
Keyword(s):  
Time Constant ◽  
Computer Model ◽  
Pyramidal Neuron ◽  
Pyramidal Neurons ◽  
Basal Dendrite ◽  
Plateau Potentials ◽  
Voltage Imaging ◽  
Plateau Potential ◽  
Cortical Pyramidal Neurons ◽  
Afferent Inputs

In cortical pyramidal neurons, we recorded glutamate-mediated dendritic plateau potentials with voltage imaging and created a computer model that recreated experimental measures from dendrite and cell body. Our model made new predictions, which were then tested in experiments. Plateau potentials profoundly change neuronal state: a plateau potential triggered in one basal dendrite depolarizes the soma and shortens membrane time constant, making the cell more susceptible to firing triggered by other afferent inputs.

scholarly journals Erratum: Corrigendum: Autism spectrum disorder susceptibility gene TAOK2 affects basal dendrite formation in the neocortex

2014 ◽  
Vol 17 (12) ◽  
pp. 1840-1840 ◽  
Author(s):  
Froylan Calderon de Anda ◽  
Ana Lucia Rosario ◽  
Omer Durak ◽  
Tracy Tran ◽  
Johannes Gräff ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Susceptibility Gene ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Basal Dendrite ◽  
Dendrite Formation

scholarly journals Spatiotemporally Graded NMDA Spike/Plateau Potentials in Basal Dendrites of Neocortical Pyramidal Neurons

2008 ◽  
Vol 99 (5) ◽  
pp. 2584-2601 ◽  
Author(s):  
Guy Major ◽  
Alon Polsky ◽  
Winfried Denk ◽  
Jackie Schiller ◽  
David W. Tank
Keyword(s):  
Decision Making ◽  
Pyramidal Neurons ◽  
Brain Slices ◽  
Dynamic Decision Making ◽  
Spatial Gradient ◽  
Basal Dendrite ◽  
Plateau Potentials ◽  
Basal Dendrites ◽  
Cortical Pyramidal Neurons

Glutamatergic inputs clustered over ∼20–40 μm can elicit local N-methyl-d-aspartate (NMDA) spike/plateau potentials in terminal dendrites of cortical pyramidal neurons, inspiring the notion that a single terminal dendrite can function as a decision-making computational subunit. A typical terminal basal dendrite is ∼100–200 μm long: could it function as multiple decision-making subunits? We test this by sequential focal stimulation of multiple sites along terminal basal dendrites of layer 5 pyramidal neurons in rat somatosensory cortical brain slices, using iontophoresis or uncaging of brief glutamate pulses. There was an approximately sevenfold spatial gradient in average spike/plateau amplitude measured at the soma, from ∼3 mV for distal inputs to ∼23 mV for proximal inputs. Spike/plateaus were NMDA receptor (NMDAR) conductance-dominated at all locations. Large Ca2+ transients accompanied spike/plateaus over a ∼10- to 40-μm zone around the input site; smaller Ca2+ transients extended approximately uniformly to the dendritic tip. Spike/plateau duration grew with increasing glutamate and depolarization; high Ca2+ zone size grew with spike/plateau duration. The minimum high Ca2+ zone half-width (just above NMDA spike threshold) increased from distal (∼10 μm) to proximal locations (∼25 μm), as did the NMDA spike glutamate threshold. Depolarization reduced glutamate thresholds. Simulations exploring multi-site interactions based on this demonstrate that if appropriately timed and localized inputs occur in vivo, a single basal dendrite could correspond to a cascade of multiple co-operating dynamic decision-making subunits able to retain information for hundreds of milliseconds, with increasing influence on neural output from distal to proximal. Dendritic NMDA spike/plateaus are thus well-suited to support graded persistent firing.

scholarly journals Temporal profile of hilar basal dendrite formation on dentate granule cells after status epilepticus

2003 ◽  
Vol 54 (2-3) ◽  
pp. 141-151 ◽  
Author(s):  
Khashayar Dashtipour ◽  
Alan M. Wong ◽  
Andre Obenaus ◽  
Igor Spigelman ◽  
Charles E. Ribak
Keyword(s):  
Status Epilepticus ◽  
Granule Cells ◽  
Basal Dendrite ◽  
Dentate Granule Cells ◽  
Temporal Profile ◽  
Dendrite Formation

scholarly journals Autism spectrum disorder susceptibility gene TAOK2 affects basal dendrite formation in the neocortex

2012 ◽  
Vol 15 (7) ◽  
pp. 1022-1031 ◽  
Author(s):  
Froylan Calderon de Anda ◽  
Ana Lucia Rosario ◽  
Omer Durak ◽  
Tracy Tran ◽  
Johannes Gräff ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Susceptibility Gene ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Basal Dendrite ◽  
Dendrite Formation

scholarly journals Local Glutamate-Mediated Dendritic Plateau Potentials Change the State of the Cortical Pyramidal Neuron

2019 ◽  
Author(s):  
Peng P. Gao ◽  
Joseph. W. Graham ◽  
Wen-Liang Zhou ◽  
Jinyoung Jang ◽  
Sergio Angulo ◽  
...  
Keyword(s):  
Cell Body ◽  
Cortical Neurons ◽  
Action Potentials ◽  
Pyramidal Neurons ◽  
Brain Slices ◽  
Basal Dendrite ◽  
Plateau Potentials ◽  
Prepared State ◽  
Cortical Pyramidal Neurons ◽  
Afferent Inputs

AbstractDendritic spikes in thin dendritic branches (basal and oblique dendrites) of pyramidal neurons are traditionally inferred from spikelets measured in the cell body. Here, we used laser-spot voltage-sensitive dye imaging in cortical pyramidal neurons (rat brain slices) to investigate the voltage waveforms of dendritic potentials occurring in response to spatially-restricted glutamatergic inputs. Local dendritic potentials lasted 200–500 ms and propagated to the cell body where they caused sustained 10-20 mV depolarizations. Plateau potentials propagating from dendrite to soma, and action potentials propagating from soma to dendrite, created complex voltage waveforms in the middle of the thin basal dendrite, comprised of local sodium spikelets, local plateau potentials, and back-propagating action potentials, superimposed on each other. Our model replicated these experimental observations and made predictions, which were tested in experiments. Dendritic plateau potentials occurring in basal and oblique branches put pyramidal neurons into an activated neuronal state (“prepared state”), characterized by depolarized membrane potential and faster membrane responses. The prepared state provides a time window of 200-500 ms during which cortical neurons are particularly excitable and capable of following afferent inputs. At the network level, this predicts that sets of cells with simultaneous plateaus would provide cellular substrate for the formation of functional neuronal ensembles.New & NoteworthyIn cortical pyramidal neurons, we recorded glutamate-mediated dendritic plateau potentials using voltage imaging, and created a computer model that recreated experimental measures from dendrite and cell body. Our model made new predictions, which were then tested in experiments. Plateau potentials profoundly change neuronal state -- a plateau potential triggered in one basal dendrite depolarizes the soma and shortens membrane time constant, making the cell more susceptible to firing triggered by other afferent inputs.

scholarly journals Getting to the root of basal dendrite formation

2012 ◽  
Vol 15 (7) ◽  
pp. 935-935
Author(s):  
Hannah Bayer
Keyword(s):  
Basal Dendrite ◽  
Dendrite Formation
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