scholarly journals dSETDB1 and SU(VAR)3–9 Sequentially Function during Germline-Stem Cell Differentiation in Drosophila melanogaster

PLoS ONE ◽  
2008 ◽  
Vol 3 (5) ◽  
pp. e2234 ◽  
Author(s):  
Jeongheon Yoon ◽  
Kyu-Sun Lee ◽  
Jung Sun Park ◽  
Kweon Yu ◽  
Sang-Gi Paik ◽  
...  
Keyword(s):  
Drosophila Melanogaster ◽  
Stem Cell ◽  
Cell Differentiation ◽  
Stem Cell Differentiation ◽  
Germline Stem Cell

scholarly journals Functional divergence of the bag of marbles gene in the Drosophila melanogaster species group

2021 ◽  
Author(s):  
Jaclyn Elizabeth Bubnell ◽  
Cynthia KS Ulbing ◽  
Paula Fernandez Begne ◽  
Charles F. Aquadro
Keyword(s):  
Drosophila Melanogaster ◽  
Stem Cell ◽  
Cell Differentiation ◽  
Stem Cell Differentiation ◽  
Species Group ◽  
Germline Stem Cell ◽  
Genetic Conflict ◽  
Differentiation Factor ◽  
Bag Of Marbles ◽  
Cell Differentiation Factor

The combination of recent advances in both genomic and gene editing technologies have opened up new possibilities for assessing the functional consequences and drivers of positive selection. In Drosophila melanogaster, a key germline stem cell differentiation factor, bag of marbles (bam) shows rapid bursts of amino acid fixations between its D. melanogaster and its sibling species D. simulans, but not in the outgroup species D. ananassae. We previously hypothesized that a genetic conflict with the maternally inherited, intracellular bacteria W. pipientis could be driving the adaptive evolution of bam as W. pipientis increases the fertility of a bam partial loss of function mutant. However, we have not been able to further test this hypothesis by assessing bam variation in other Drosophila lineages and their interactions with W. pipientis because bam function has not been examined in non-melanogaster Drosophila species. Since bam is rapidly evolving at the protein level, its function may not be conserved between species, and therefore different evolutionary pressures may be shaping bam in individual lineages. Here, we ask if bam is necessary for GSC daughter differentiation in five Drosophila species in the melanogaster species group that span approximately 15 million years of divergence and show different patterns of nucleotide sequence evolution at bam. We find that bam function is not fully conserved across these species, and that bam function may change on a relatively short time scale. Ultimately, we conclude that a simple gain in function as the germline stem cell differentiation factor alone does not explain our population genetic and functional genetic results we have observed. Our findings provide a foundation on which to explore the evolution of bam as a GSC differentiation factor and its interactions with W. pipientis in specific lineages.

scholarly journals Regulation of Ribosome Biogenesis and Protein Synthesis Controls Germline Stem Cell Differentiation

2016 ◽  
Vol 18 (2) ◽  
pp. 276-290 ◽  
Author(s):  
Carlos G. Sanchez ◽  
Felipe Karam Teixeira ◽  
Benjamin Czech ◽  
Jonathan B. Preall ◽  
Andrea L. Zamparini ◽  
...  
Keyword(s):  
Protein Synthesis ◽  
Stem Cell ◽  
Cell Differentiation ◽  
Ribosome Biogenesis ◽  
Stem Cell Differentiation ◽  
Germline Stem Cell

scholarly journals DNA Methylation and Regulatory Elements during Chicken Germline Stem Cell Differentiation

2018 ◽  
Vol 10 (6) ◽  
pp. 1793-1806 ◽  
Author(s):  
Yanghua He ◽  
Qisheng Zuo ◽  
John Edwards ◽  
Keji Zhao ◽  
Jinzhi Lei ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Stem Cell ◽  
Cell Differentiation ◽  
Stem Cell Differentiation ◽  
Regulatory Elements ◽  
Germline Stem Cell

scholarly journals Mitochondrial maturation drives germline stem cell differentiation in Caenorhabditis elegans

2019 ◽  
Vol 27 (2) ◽  
pp. 601-617 ◽  
Author(s):  
Nikolaos Charmpilas ◽  
Nektarios Tavernarakis
Keyword(s):  
Stem Cell ◽  
Cell Differentiation ◽  
Caenorhabditis Elegans ◽  
Stem Cell Differentiation ◽  
Germline Stem Cell

scholarly journals Control of germline stem cell differentiation by Polycomb and Trithorax group genes in the niche microenvironment

Development ◽  
2016 ◽  
Vol 143 (19) ◽  
pp. 3449-3458 ◽  
Author(s):  
Xuewen Li ◽  
Fu Yang ◽  
Hongyan Chen ◽  
Bowen Deng ◽  
Xinghua Li ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Differentiation ◽  
Stem Cell Differentiation ◽  
Germline Stem Cell ◽  
Trithorax Group

scholarly journals The exocyst functions in niche cells to promote germline stem cell differentiation by directly controlling EGFR membrane trafficking

Development ◽  
2019 ◽  
Vol 146 (13) ◽  
pp. dev174615 ◽  
Author(s):  
Ying Mao ◽  
Renjun Tu ◽  
Yan Huang ◽  
Decai Mao ◽  
Zhihao Yang ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Differentiation ◽  
Membrane Trafficking ◽  
Stem Cell Differentiation ◽  
Germline Stem Cell

scholarly journals A switch in the mode of Wnt signaling orchestrates the formation of germline stem cell differentiation niche in Drosophila

PLoS Genetics ◽  
2018 ◽  
Vol 14 (1) ◽  
pp. e1007154 ◽  
Author(s):  
Maitreyi Upadhyay ◽  
Michael Kuna ◽  
Sara Tudor ◽  
Yesenia Martino Cortez ◽  
Prashanth Rangan
Keyword(s):  
Stem Cell ◽  
Cell Differentiation ◽  
Wnt Signaling ◽  
Stem Cell Differentiation ◽  
Germline Stem Cell

scholarly journals Without children is required for Stat-mediated zfh1 transcription and for germline stem cell differentiation

Development ◽  
2014 ◽  
Vol 141 (13) ◽  
pp. 2602-2610 ◽  
Author(s):  
I. Maimon ◽  
M. Popliker ◽  
L. Gilboa
Keyword(s):  
Stem Cell ◽  
Cell Differentiation ◽  
Stem Cell Differentiation ◽  
Germline Stem Cell

scholarly journals Ci antagonizes Hippo signaling in the somatic cells of the ovary to drive germline stem cell differentiation

Cell Research ◽  
2015 ◽  
Vol 25 (10) ◽  
pp. 1152-1170 ◽  
Author(s):  
Chaoyi Li ◽  
Lijuan Kan ◽  
Yan Chen ◽  
Xiudeng Zheng ◽  
Weini Li ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Differentiation ◽  
Somatic Cells ◽  
Stem Cell Differentiation ◽  
Germline Stem Cell ◽  
Hippo Signaling
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