scholarly journals Protection of Retinal Ganglion Cells and Retinal Vasculature by Lycium Barbarum Polysaccharides in a Mouse Model of Acute Ocular Hypertension

PLoS ONE ◽  
2012 ◽  
Vol 7 (10) ◽  
pp. e45469 ◽  
Author(s):  
Xue-Song Mi ◽  
Qian Feng ◽  
Amy Cheuk Yin Lo ◽  
Raymond Chuen-Chung Chang ◽  
Bin Lin ◽  
...  
Keyword(s):  
Mouse Model ◽  
Ocular Hypertension ◽  
Retinal Ganglion Cells ◽  
Ganglion Cells ◽  
Retinal Vasculature ◽  
Retinal Ganglion ◽  
Lycium Barbarum ◽  
Lycium Barbarum Polysaccharides

Neuroprotective effects of Lycium barbarum Lynn on protecting retinal ganglion cells in an ocular hypertension model of glaucoma

2007 ◽  
Vol 203 (1) ◽  
pp. 269-273 ◽  
Author(s):  
Hiu-Chi Chan ◽  
Raymond Chuen-Chung Chang ◽  
Angel Koon-Ching Ip ◽  
Kin Chiu ◽  
Wai-Hung Yuen ◽  
...  
Keyword(s):  
Ocular Hypertension ◽  
Retinal Ganglion Cells ◽  
Ganglion Cells ◽  
Retinal Ganglion ◽  
Lycium Barbarum ◽  
Neuroprotective Effects

scholarly journals Axons of retinal ganglion cells are insulted in the optic nerve early in DBA/2J glaucoma

2007 ◽  
Vol 179 (7) ◽  
pp. 1523-1537 ◽  
Author(s):  
Gareth R. Howell ◽  
Richard T. Libby ◽  
Tatjana C. Jakobs ◽  
Richard S. Smith ◽  
F. Campbell Phalan ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Mouse Model ◽  
Retinal Ganglion Cells ◽  
Strong Evidence ◽  
Ganglion Cells ◽  
Lamina Cribrosa ◽  
Retinal Ganglion ◽  
Rich Region ◽  
Pattern Electroretinography ◽  
Axon Damage

Here, we use a mouse model (DBA/2J) to readdress the location of insult(s) to retinal ganglion cells (RGCs) in glaucoma. We localize an early sign of axon damage to an astrocyte-rich region of the optic nerve just posterior to the retina, analogous to the lamina cribrosa. In this region, a network of astrocytes associates intimately with RGC axons. Using BAX-deficient DBA/2J mice, which retain all of their RGCs, we provide experimental evidence for an insult within or very close to the lamina in the optic nerve. We show that proximal axon segments attached to their cell bodies survive to the proximity of the lamina. In contrast, axon segments in the lamina and behind the eye degenerate. Finally, the Wlds allele, which is known to protect against insults to axons, strongly protects against DBA/2J glaucoma and preserves RGC activity as measured by pattern electroretinography. These experiments provide strong evidence for a local insult to axons in the optic nerve.

scholarly journals The effect of celastrol on the ocular hypertension-induced degeneration of retinal ganglion cells

2018 ◽  
Vol 670 ◽  
pp. 89-93 ◽  
Author(s):  
Lei Gu ◽  
Jacky M.K. Kwong ◽  
Daniel Yadegari ◽  
Fei Yu ◽  
Joseph Caprioli ◽  
...  
Keyword(s):  
Ocular Hypertension ◽  
Retinal Ganglion Cells ◽  
Ganglion Cells ◽  
Retinal Ganglion
Sign in / Sign up

Export Citation Format

Share Document