scholarly journals Tanshinone IIA Increases the Bystander Effect of Herpes Simplex Virus Thymidine Kinase/Ganciclovir Gene Therapy via Enhanced Gap Junctional Intercellular Communication

PLoS ONE ◽  
2013 ◽  
Vol 8 (7) ◽  
pp. e67662 ◽  
Author(s):  
Jianyong Xiao ◽  
Guangxian Zhang ◽  
Pengxiang Qiu ◽  
Xijuan Liu ◽  
Yingya Wu ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Thymidine Kinase ◽  
Intercellular Communication ◽  
Bystander Effect ◽  
Tanshinone Iia ◽  
Gap Junctional Intercellular Communication ◽  
Simplex Virus ◽  
Gap Junctional

Potent Bystander Effect in Suicide Gene Therapy Using Neural Stem Cells Transduced with Herpes Simplex Virus Thymidine Kinase Gene

Oncology ◽  
2005 ◽  
Vol 69 (6) ◽  
pp. 503-508 ◽  
Author(s):  
Shaoyi Li ◽  
Tsutomu Tokuyama ◽  
Junkoh Yamamoto ◽  
Masayo Koide ◽  
Naoki Yokota ◽  
...  
Keyword(s):  
Stem Cells ◽  
Gene Therapy ◽  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Thymidine Kinase ◽  
Bystander Effect ◽  
Suicide Gene ◽  
Thymidine Kinase Gene ◽  
Kinase Gene ◽  
Simplex Virus

Pharmacological modulation of the bystander effect in the herpes simplex virus thymidine kinase/ganciclovir gene therapy system

2000 ◽  
Vol 60 (2) ◽  
pp. 241-249 ◽  
Author(s):  
Pierre Alain Robe ◽  
Frédéric Princen ◽  
Didier Martin ◽  
Brigitte Malgrange ◽  
Achille Stevenaert ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Thymidine Kinase ◽  
Bystander Effect ◽  
Pharmacological Modulation ◽  
Simplex Virus

scholarly journals Retinoids augment the bystander effect in vitro and in vivo in herpes simplex virus thymidine kinase/ganciclovir-mediated gene therapy

Gene Therapy ◽  
1997 ◽  
Vol 4 (9) ◽  
pp. 909-917 ◽  
Author(s):  
JY Park ◽  
AA Elshami ◽  
K Amin ◽  
N Rizk ◽  
LR Kaiser ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Thymidine Kinase ◽  
Bystander Effect ◽  
Simplex Virus

scholarly journals Killing Effect of the Herpes Simplex Virus Thymidine Kinase/Ganciclovir Enzyme/Prodrug System on Human Nasopharyngeal Carcinoma Cells

2007 ◽  
Vol 35 (4) ◽  
pp. 433-441 ◽  
Author(s):  
Y Tang ◽  
J Li ◽  
S Zhao ◽  
J Liu
Keyword(s):  
Gene Therapy ◽  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Nasopharyngeal Carcinoma ◽  
Thymidine Kinase ◽  
Recombinant Plasmid ◽  
Bystander Effect ◽  
Dependent Manner ◽  
Human Nasopharyngeal Carcinoma ◽  
Simplex Virus

A promising new approach for the gene therapy of cancer is the introduction of the herpes simplex virus thymidine kinase (HSV tk) gene into tumour cells, where the HSV tk gene product converts the non-toxic prodrug ganciclovir (GCV) into its cytotoxic metabolite. We constructed a recombinant plasmid containing the HSV tk gene using standard molecular biology techniques in order to investigate whether the HSV tk/GCV enzyme/prodrug system could kill the human nasopharyngeal carcinoma cell line HNE-1. The recombinant plasmid pcDNA3.1(–) CMV.TK was transfected into the HNE-1 cells by electroporation. The expression of HSV tk by the transfected HNE-1/TK cells was confirmed by mRNA amplification and Western blotting. The growth of HNE-1/TK cells was inhibited by GCV in a dose-dependent manner. The HSV tk/GCV system also demonstrated a considerable bystander effect on co-cultured wild type HNE-1 cells. We conclude that the HSV tk/GCV system could be used as gene therapy for nasopharyngeal carcinoma.

scholarly journals Herpes simplex virus-type 2 infectivity and agents that block gap junctional intercellular communication

2007 ◽  
Vol 124 (1-2) ◽  
pp. 212-219 ◽  
Author(s):  
Maureen T. Knabb ◽  
Casey A. Danielsen ◽  
Kerry McShane-Kay ◽  
Gustave K.N. Mbuy ◽  
Richard I. Woodruff
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Virus Type ◽  
Intercellular Communication ◽  
Herpes Simplex Virus Type ◽  
Gap Junctional Intercellular Communication ◽  
Simplex Virus ◽  
Gap Junctional
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