Association between Dental Caries and Down Syndrome: A Systematic Review and Meta-Analysis

AbstractThe objective of this systematic review and meta-analysis is to critically analyze and summarize studies reporting association of salivary immunoglobulin A (IgA) levels as a biomarker for dental caries in Down syndrome (DS) patients. Using the keywords salivary [All Fields] AND IgA [All Fields] AND (“down syndrome” [MeSH Terms] OR (“down”[All Fields] AND “syndrome” [All Fields]) OR “down syndrome” [All Fields]), an electronic search was conducted via PubMed and Scopus databases by two authors, H. H. and Z. K. independently. Retrieved studies were screened against the predefined exclusion and inclusion criteria. To estimate the risk of bias, quality assessment of included studies was carried using the Newcastle–Ottawa quality assessment scale for observational studies. Primary search resulted in 10 articles from PubMed and 13 articles from Scopus. Ten studies fulfilled the defined selection criteria and evaluated the salivary IgA (sIgA) level in DS patients with dental caries. Five articles were further analyzed in a quantitative synthesis presented in the meta-analysis. Due to a modified lifestyle and compromised oral hygiene in DS patients, understandably, it is still postulated in the literature that the presence of sIgA can have a protective effect on the occurrence of dental caries as compared with healthy counterparts. As indicated by the present meta-analysis, no conclusions can be drawn as to definitively label sIgA as a biomarker for dental caries. Further, well-designed longitudinal clinical studies and translational research are therefore required before the benchmarking of sIgA as a useful biomarker for dental caries in DS patients with preferable molecular insights.

Download Full-text

Does non-institutionalized elders have a better oral health status compared to institutionalized ones? A systematic review and meta-analysis

Ciência & Saúde Coletiva ◽

10.1590/1413-81232020256.18252018 ◽

2020 ◽

Vol 25 (6) ◽

pp. 2177-2192 ◽

Cited By ~ 3

Author(s):

Ilky Pollansky Silva e Farias ◽

Simone Alves de Sousa ◽

Leopoldina de Fátima Dantas de Almeida ◽

Bianca Marques Santiago ◽

Antonio Carlos Pereira ◽

...

Keyword(s):

Systematic Review ◽

Health Status ◽

Oral Health ◽

Dental Caries ◽

Meta Analysis ◽

Oral Health Status ◽

Cochrane Library ◽

Caries Experience ◽

Institutionalized Elderly ◽

Periodontal Status

Abstract This systematic review compared the oral health status between institutionalized and non-institutionalized elders. The following electronic databases were searched: PubMed (Medline), Scopus, Web of Science, Lilacs and Cochrane Library, in a comprehensive and unrestricted manner. Electronic searches retrieved 1687 articles, which were analyzed with regards to respective eligibility criteria. After reading titles and abstracts, five studies were included and analyzed with respect their methodological quality. Oral status of institutionalized and non-institutionalized elderly was compared through meta-analysis. Included articles involved a cross-sectional design, which investigated 1936 individuals aged 60 years and over, being 999 Institutionalized and 937 non-institutionalized elders. Studies have investigated the prevalence of edentulous individuals, the dental caries experience and the periodontal status. Meta-analysis revealed that institutionalized elderly have greater prevalence of edentulous (OR = 2.28, 95%CI = 1.68-3.07) and higher number of decayed teeth (MD = 0.88, 95%CI = 0.71-1.05) and missed teeth (MD = 4.58, 95%CI = 1.89-7.27). Poor periodontal status did not differ significantly between groups. Compared to non-institutionalized, institutionalized elders have worse dental caries experience.

Download Full-text

Tongue-Based Procedures in Treating Refractory Obstructive Sleep Apnea in Down Syndrome Patients: A Systematic Review and Meta-Analysis

FACE ◽

10.1177/2732501621992447 ◽

2021 ◽

Vol 2 (1) ◽

pp. 65-70

Author(s):

Paul B. Lee ◽

Michael T. Chung ◽

Jared Johnson ◽

Jordyn Lucas ◽

Caitlin R. Priest ◽

...

Keyword(s):

Systematic Review ◽

Obstructive Sleep Apnea ◽

Down Syndrome ◽

Sleep Apnea ◽

Nerve Stimulation ◽

Hypoglossal Nerve ◽

Meta Analysis ◽

Apnea Hypopnea Index ◽

Hypoglossal Nerve Stimulation ◽

Obstructive Sleep

Objective: There is a high prevalence of obstructive sleep apnea (OSA) in pediatric and adult Down Syndrome (DS) patients that is refractory to adenotonsillectomy and continuous positive airway pressure. Newer treatment modalities have emerged with improved outcomes. The objective is to provide an updated systematic review and meta-analysis to analyze the clinical outcomes of OSA in pediatric and adult DS patients with hypoglossal nerve stimulation using Inspire, midline posterior glossectomy plus lingual tonsillectomy (MPG + LT), and combined genioglossus advancement plus radiofrequency (GGS + RF). Methods: A comprehensive literature search of PubMed and Google Scholar was performed followed by a meta-analysis. Studies with preoperative and post-operative Apnea Hypopnea Index (AHI) values were included with patients serving as their own control. Results: Across 5 studies, 56 patients were analyzed. The mean reduction in AHI was statistically significant before vs. after procedure ( P < .001 for hypoglossal nerve stimulation using Inspire with a paired 2-tailed t-test and P = .031 for MPG + LT). Although individual patient AHI values were unavailable in the GGS + RF study, the standard difference in mean AHI was also significant for GGS + RF with P = .001. Device malfunction was the most common complication for Inspire while postoperative bleeding was observed for MPG + LT and nasopharyngeal obstruction and retropalatal collapse were observed for GGS + RF. Conclusion: This review reveals significant improvement in AHI with Inspire, MPG + LT, and GGS + RF for DS patients with refractory OSA. Further investigation is needed for comparison between these 3 therapies.

Download Full-text

Heart rate variability in individuals with Down syndrome – A systematic review and meta-analysis

Autonomic Neuroscience ◽

10.1016/j.autneu.2018.05.006 ◽

2018 ◽

Vol 213 ◽

pp. 23-33 ◽

Cited By ~ 9

Author(s):

Tatiana Dias de Carvalho ◽

Thais Massetti ◽

Talita Dias da Silva ◽

Tânia Brusque Crocetta ◽

Regiani Guarnieri ◽

...

Keyword(s):

Systematic Review ◽

Heart Rate ◽

Heart Rate Variability ◽

Down Syndrome ◽

Meta Analysis

Download Full-text

Dental caries experience, care index and restorative index in children with learning disabilities and children without learning disabilities: a systematic review and meta-analysis

Evidence-Based Dentistry ◽

10.1038/s41432-020-0075-9 ◽

2020 ◽

Vol 21 (1) ◽

pp. 16-17

Author(s):

James Bird ◽

Zoe Marshman

Keyword(s):

Systematic Review ◽

Learning Disabilities ◽

Dental Caries ◽

Meta Analysis ◽

Caries Experience ◽

Care Index

Download Full-text

Global prevalence of dental caries in athletes with intellectual disabilities: An epidemiological systematic review and meta-analysis

Special Care in Dentistry ◽

10.1111/scd.12349 ◽

2018 ◽

Vol 39 (2) ◽

pp. 114-124 ◽

Cited By ~ 3

Author(s):

Fellipe Navarro Azevedo de Azeredo ◽

Ludmila Silva Guimarães ◽

Lívia Azeredo A. Antunes ◽

Leonardo Santos Antunes

Keyword(s):

Systematic Review ◽

Dental Caries ◽

Intellectual Disabilities ◽

Meta Analysis ◽

Global Prevalence

Download Full-text

Association between sense of coherence and dental caries: systematic review and meta-analysis

Health Promotion International ◽

10.1093/heapro/daz038 ◽

2019 ◽

Vol 35 (3) ◽

pp. 586-597 ◽

Cited By ~ 2

Author(s):

Thaís Ariane Perdigão Torres ◽

Larissa Corradi-Dias ◽

Patrícia Drummond Oliveira ◽

Carolina Castro Martins ◽

Saul Martins Paiva ◽

...

Keyword(s):

Systematic Review ◽

Dental Caries ◽

Quality Assessment ◽

Sense Of Coherence ◽

Web Of Science ◽

Meta Analysis ◽

Reference List ◽

High Quality ◽

Hand Search ◽

Quality Study

Abstract Sense of coherence (SOC) is regarded as the individuals' capacity for managing the stressors over their lifespan. The aim of this systematic review and meta-analysis was to evaluate the association between SOC and dental caries. Electronic searchers were conducted in six databases: PubMed, Medline, Scopus, Web of Science, Lilacs and Proquest from their date of inception until November/2017. An update took place in August/2018. A hand search in the reference list of the included articles and gray literature search were also carried out. Retrieved titles/abstracts were screened by two review authors. Data of the included articles were extracted and quality assessment was also conducted. The first search retrieved 346 titles/abstracts. The update retrieved 33 records. Following the removal of 70 duplicates, 309 references were screened and 17 were included. The quality assessment ranged from low quality articles to high quality articles. High quality study showed that adult individuals with lower SOC were more likely to have dental caries. Meta-analysis showed that adolescents with low SOC were 5.41 times more likely to present dental caries than adolescents with high SOC (CI = 2.15–13.59). Mothers with low SOC were 5.55 times more likely to have children/adolescents with dental caries than mothers with high SOC (CI = 2.92–10.57). The subgroup analysis exploring continuous data showed that the SOC of mothers of children/adolescents without dental caries was significantly higher than the SOC of mothers of children/adolescents with dental caries (CI = 0.10–0.51). Higher levels of SOC seem to be associated with lower levels of dental caries.

Download Full-text