scholarly journals Age-related differences in skeletal muscle microvascular response to exercise as detected by contrast-enhanced ultrasound (CEUS)

PLoS ONE ◽  
2017 ◽  
Vol 12 (3) ◽  
pp. e0172771 ◽  
Author(s):  
Wulf Hildebrandt ◽  
Hans Schwarzbach ◽  
Anita Pardun ◽  
Lena Hannemann ◽  
Björn Bogs ◽  
...  
2013 ◽  
Vol 1 (5) ◽  
Author(s):  
William Kyle Mitchell ◽  
Bethan E. Phillips ◽  
John P. Williams ◽  
Debbie Rankin ◽  
Kenneth Smith ◽  
...  

2017 ◽  
Vol 43 (9) ◽  
pp. 2013-2023 ◽  
Author(s):  
Sarah J. Blackwood ◽  
Renee M. Dwyer ◽  
Eloise A. Bradley ◽  
Michelle A. Keske ◽  
Stephen M. Richards ◽  
...  

2011 ◽  
Vol 46 (8) ◽  
pp. 504-508 ◽  
Author(s):  
Erick Amarteifio ◽  
Marc-André Weber ◽  
Stephanie Wormsbecher ◽  
Serdar Demirel ◽  
Holger Krakowski-Roosen ◽  
...  

2007 ◽  
Vol 39 (Supplement) ◽  
pp. S429
Author(s):  
Christopher K. Davis ◽  
Brian A. Irving ◽  
David W. Brock ◽  
Glenn A. Gaesser ◽  
Eugene J. Barrett ◽  
...  

2002 ◽  
Vol 282 (3) ◽  
pp. E714-E720 ◽  
Author(s):  
Dana Dawson ◽  
Michelle A. Vincent ◽  
Eugene J. Barrett ◽  
Sanjiv Kaul ◽  
Andrew Clark ◽  
...  

The purpose of this study was to noninvasively quantify the effects of insulin on capillary blood volume (capBV) and RBC velocity ( V RBC) in skeletal muscle in vivo with the use of contrast-enhanced ultrasound. We performed contrast ultrasound of the rat hindlimb adductor muscles at baseline and after 2-h infusions of either insulin (3 or 40 mU · kg−1 · min−1) or saline. Saline-treated animals were also studied during contractile exercise. V RBC and capBV were calculated from the relation between pulsing interval and video intensity. Femoral artery blood flow, measured by a flow probe, increased with both contractile exercise and insulin. Contractile exercise increased capBV more than twofold and V RBC fivefold. Insulin also increased capBV more than twofold in a dose-dependent fashion but did not significantly alter V RBC. Saline infusion did not significantly alter capBV, V RBC, or femoral artery blood flow. We conclude that physiological changes in skeletal muscle capillary perfusion can be assessed in vivo with the use of contrast-enhanced ultrasound. Exercise increases both V RBC and capBV, whereas hyperinsulinemia selectively increases only capBV, which may enhance skeletal muscle glucose uptake.


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