Novel histone deacetylase inhibitor AR-42 exhibits antitumor activity in pancreatic cancer cells by affecting multiple biochemical pathways

PLoS ONE ◽

10.1371/journal.pone.0183368 ◽

2017 ◽

Vol 12 (8) ◽

pp. e0183368 ◽

Author(s):

Yi-Jin Chen ◽

Wen-Hung Wang ◽

Wan-Yu Wu ◽

Chia-Chi Hsu ◽

Ling-Rung Wei ◽

...

Keyword(s):

Pancreatic Cancer ◽

Antitumor Activity ◽

Cancer Cells ◽

Histone Deacetylase ◽

Histone Deacetylase Inhibitor ◽

Biochemical Pathways ◽

Pancreatic Cancer Cells ◽

Deacetylase Inhibitor

Download Full-text

Histone deacetylase inhibitor, suberoylanilide hydroxamic acid (Vorinostat, SAHA) profoundly inhibits the growth of human pancreatic cancer cells

International Journal of Cancer ◽

10.1002/ijc.22558 ◽

2007 ◽

Vol 121 (3) ◽

pp. 656-665 ◽

Author(s):

Takashi Kumagai ◽

Naoki Wakimoto ◽

Dong Yin ◽

Sigal Gery ◽

Norihiko Kawamata ◽

...

Keyword(s):

Pancreatic Cancer ◽

Cancer Cells ◽

Histone Deacetylase ◽

Histone Deacetylase Inhibitor ◽

Hydroxamic Acid ◽

Human Pancreatic Cancer ◽

Suberoylanilide Hydroxamic Acid ◽

Pancreatic Cancer Cells ◽

Deacetylase Inhibitor

Download Full-text

Abstract 203: The histone deacetylase inhibitor LBH589 sensitizes pancreatic cancer cells to TRAIL-induced apoptosis through induction of c-FLIP degradation

10.1158/1538-7445.am10-203 ◽

2010 ◽

Author(s):

John Kauh ◽

Songqing Fan ◽

Lily Yang ◽

Fadlo R. Khuri ◽

Shi-Yong Sun

Keyword(s):

Pancreatic Cancer ◽

Cancer Cells ◽

Histone Deacetylase ◽

Histone Deacetylase Inhibitor ◽

Pancreatic Cancer Cells ◽

Deacetylase Inhibitor ◽

Induced Apoptosis

Download Full-text

FR901228, a novel histone deacetylase inhibitor, induces cell cycle arrest and subsequent apoptosis in refractory human pancreatic cancer cells

International Journal of Oncology ◽

10.3892/ijo.24.3.679 ◽

2004 ◽

Author(s):

Nariatsu Sato ◽

Tetsuo Ohta ◽

Hirohisa Kitagawa ◽

Masato Kayahara ◽

Itasu Ninomiya ◽

...

Keyword(s):

Pancreatic Cancer ◽

Cell Cycle Arrest ◽

Cancer Cells ◽

Histone Deacetylase ◽

Histone Deacetylase Inhibitor ◽

Human Pancreatic Cancer ◽

Cycle Arrest ◽

Pancreatic Cancer Cells ◽

Deacetylase Inhibitor

Download Full-text

Growth inhibition of pancreatic cancer cells by histone deacetylase inhibitor belinostat through suppression of multiple pathways including HIF, NFkB, and mTOR signaling in vitro and in vivo

Molecular Carcinogenesis ◽

10.1002/mc.22024 ◽

2013 ◽

Vol 53 (9) ◽

pp. 722-735 ◽

Author(s):

Wenwen Chien ◽

Dhong Hyun Lee ◽

Yun Zheng ◽

Peer Wuensche ◽

Rosie Alvarez ◽

...

Keyword(s):

Pancreatic Cancer ◽

Growth Inhibition ◽

Cancer Cells ◽

Histone Deacetylase ◽

Histone Deacetylase Inhibitor ◽

Mtor Signaling ◽

Pancreatic Cancer Cells ◽

Deacetylase Inhibitor

Download Full-text

Effects of a histone deacetylase inhibitor, sodium butyrate, on 53-kDa protein expression and sensitivity to anticancer drugs of pancreatic cancer cells

Current Therapeutic Research ◽

10.1016/j.curtheres.2010.06.002 ◽

2010 ◽

Vol 71 (3) ◽

pp. 162-172 ◽

Author(s):

Masaki Kitazono ◽

Hiroyuki Shinchi ◽

Sumiya Ishigami ◽

Shinichi Ueno ◽

Shoji Natsugoe

Keyword(s):

Pancreatic Cancer ◽

Protein Expression ◽

Cancer Cells ◽

Histone Deacetylase ◽

Anticancer Drugs ◽

Sodium Butyrate ◽

Histone Deacetylase Inhibitor ◽

Pancreatic Cancer Cells ◽

Deacetylase Inhibitor

Download Full-text

Histone deacetylase inhibitor augments anti-tumor effect of gemcitabine and pegylated interferon-α on pancreatic cancer cells

International Journal of Clinical Oncology ◽

10.1007/s10147-011-0246-y ◽

2011 ◽

Vol 16 (6) ◽

pp. 671-678 ◽

Author(s):

Shuichi Iwahashi ◽

Mitsuo Shimada ◽

Tohru Utsunomiya ◽

Yuji Morine ◽

Satoru Imura ◽

...

Keyword(s):

Pancreatic Cancer ◽

Cancer Cells ◽

Histone Deacetylase ◽

Histone Deacetylase Inhibitor ◽

Pegylated Interferon ◽

Interferon Α ◽

Pancreatic Cancer Cells ◽

Deacetylase Inhibitor

Download Full-text

Histone deacetylase inhibitor trichostatin A and proteasome inhibitor PS-341 synergistically induce apoptosis in pancreatic cancer cells

Biochemical and Biophysical Research Communications ◽

10.1016/j.bbrc.2006.07.185 ◽

2006 ◽

Vol 348 (4) ◽

pp. 1245-1253 ◽

Author(s):

Jirong Bai ◽

Aram Demirjian ◽

Jianhua Sui ◽

Wayne Marasco ◽

Mark P. Callery

Keyword(s):

Pancreatic Cancer ◽

Cancer Cells ◽

Histone Deacetylase ◽

Histone Deacetylase Inhibitor ◽

Proteasome Inhibitor ◽

Trichostatin A ◽

Pancreatic Cancer Cells ◽

Deacetylase Inhibitor ◽

Histone Deacetylase Inhibitor Trichostatin

Download Full-text

c-FLIP Degradation Mediates Sensitization of Pancreatic Cancer Cells to TRAIL-Induced Apoptosis by the Histone Deacetylase Inhibitor LBH589

PLoS ONE ◽

10.1371/journal.pone.0010376 ◽

2010 ◽

Vol 5 (4) ◽

pp. e10376 ◽

Author(s):

John Kauh ◽

Songqing Fan ◽

Mingjing Xia ◽

Ping Yue ◽

Lily Yang ◽

...

Keyword(s):

Pancreatic Cancer ◽

Cancer Cells ◽

Histone Deacetylase ◽

Histone Deacetylase Inhibitor ◽

Pancreatic Cancer Cells ◽

Deacetylase Inhibitor ◽

Induced Apoptosis

Download Full-text

Chidamide, a novel histone deacetylase inhibitor, synergistically enhances gemcitabine cytotoxicity in pancreatic cancer cells

Biochemical and Biophysical Research Communications ◽

10.1016/j.bbrc.2013.03.059 ◽

2013 ◽

Vol 434 (1) ◽

pp. 95-101 ◽

Author(s):

Zhixin Qiao ◽

Suping Ren ◽

Weijing Li ◽

Xuanlin Wang ◽

Min He ◽

...

Keyword(s):

Pancreatic Cancer ◽

Cancer Cells ◽

Histone Deacetylase ◽

Histone Deacetylase Inhibitor ◽

Pancreatic Cancer Cells ◽

Deacetylase Inhibitor

Download Full-text

Modulation of adhesion and growth of colon and pancreatic cancer cells by the histone deacetylase inhibitor valproic acid

International Journal of Molecular Medicine ◽

10.3892/ijmm_00000022 ◽

1998 ◽

Author(s):

Jones

Keyword(s):

Pancreatic Cancer ◽

Valproic Acid ◽

Cancer Cells ◽

Histone Deacetylase ◽

Histone Deacetylase Inhibitor ◽

Pancreatic Cancer Cells ◽

Deacetylase Inhibitor

Download Full-text