scholarly journals Ecological factors associated with persistent circulation of multiple highly pathogenic avian influenza viruses among poultry farms in Taiwan during 2015-17

PLoS ONE ◽  
2020 ◽  
Vol 15 (8) ◽  
pp. e0236581
Author(s):  
Wei-Shan Liang ◽  
Yu-Chen He ◽  
Hong-Dar Wu ◽  
Yao-Tsun Li ◽  
Tai-Hwa Shih ◽  
...  
2021 ◽  
Author(s):  
Pierre Bessière ◽  
Thomas Figueroa ◽  
Amelia Coggon ◽  
Charlotte Foret-Lucas ◽  
Alexandre Houffschmitt ◽  
...  

Highly pathogenic avian influenza viruses (HPAIV) emerge from low pathogenic avian influenza viruses (LPAIV) through the introduction of basic amino acids at the hemagglutinin (HA) cleavage site. Following viral evolution, the newly formed HPAIV likely represents a minority variant within the index host, predominantly infected with the LPAIV precursor. Using reverse-genetics engineered H5N8 viruses differing solely at the HA cleavage, we tested the hypothesis that the interaction between the minority HPAIV and the majority LPAIV could modulate the risk of HPAIV emergence and that the nature of the interaction could depend on the host species. In chickens, we observed that the H5N8 LP increased H5N8 HP replication and pathogenesis. By contrast, the H5N8 LP antagonized H5N8 HP replication and pathogenesis in ducks. Ducks mounted a more potent antiviral innate immune response than chickens against the H5N8 LP , which correlated with H5N8 HP inhibition. These data provide experimental evidence that HPAIV may be more likely to emerge in chickens than in ducks and underscore the importance of within-host viral variants interactions in viral evolution. IMPORTANCE Highly pathogenic avian influenza viruses represent a threat to poultry production systems and to human health because of their impact on food security and because of their zoonotic potential. It is therefore crucial to better understand how these viruses emerge. Using a within-host competition model between highly and low pathogenic avian influenza viruses, we provide evidence that highly pathogenic avian influenza viruses could be more likely to emerge in chickens than in ducks. These results have important implications for highly pathogenic avian influenza virus emergence prevention and they underscore the importance of within-host viral variants interactions in virus evolution.


2009 ◽  
Vol 133 (1-2) ◽  
pp. 65-74 ◽  
Author(s):  
Takehiko Saito ◽  
Chiaki Watanabe ◽  
Nobuhiro Takemae ◽  
Arunee Chaisingh ◽  
Yuko Uchida ◽  
...  

2021 ◽  
Vol 65 (3) ◽  
Author(s):  
Aya Matsuu ◽  
Taichiro Tanikawa ◽  
Yoshikazu Fujimoto ◽  
Mihoko Yabuki ◽  
Ryota Tsunekuni ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document