scholarly journals Mitigation of liquid–liquid phase separation of a monoclonal antibody by mutations of negative charges on the Fab surface

PLoS ONE ◽  
2020 ◽  
Vol 15 (10) ◽  
pp. e0240673
Author(s):  
Tatsuji Matsuoka ◽  
Ryuki Miyauchi ◽  
Nobumi Nagaoka ◽  
Jun Hasegawa
Keyword(s):  
Monoclonal Antibody ◽  
Phase Separation ◽  
Liquid Phase ◽  
Liquid Phase Separation ◽  
Liquid Liquid Phase Separation

scholarly journals Investigating Liquid–Liquid Phase Separation of a Monoclonal Antibody Using Solution-State NMR Spectroscopy: Effect of Arg·Glu and Arg·HCl

2017 ◽  
Vol 14 (8) ◽  
pp. 2852-2860 ◽  
Author(s):  
Priscilla Kheddo ◽  
Jack E. Bramham ◽  
Rebecca J. Dearman ◽  
Shahid Uddin ◽  
Christopher F. van der Walle ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Phase Separation ◽  
Nmr Spectroscopy ◽  
Liquid Phase ◽  
Liquid Phase Separation ◽  
Solution State ◽  
Liquid Liquid Phase Separation

scholarly journals On the Aggregation and Nucleation Mechanism of the Monoclonal Antibody Anti-CD20 Near Liquid-Liquid Phase Separation (LLPS)

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Elvira Pantuso ◽  
Teresa F. Mastropietro ◽  
Maria L. Briuglia ◽  
Charline J. J. Gerard ◽  
Efrem Curcio ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Phase Separation ◽  
Liquid Phase ◽  
Nucleation Mechanism ◽  
Liquid Phase Separation ◽  
Anti Cd20 ◽  
Liquid Liquid Phase Separation

scholarly journals Stability of a high-concentration monoclonal antibody solution produced by liquid–liquid phase separation

mAbs ◽  
2021 ◽  
Vol 13 (1) ◽  
pp. 1940666
Author(s):  
Jack E. Bramham ◽  
Stephanie A. Davies ◽  
Adrian Podmore ◽  
Alexander P. Golovanov
Keyword(s):  
Monoclonal Antibody ◽  
Phase Separation ◽  
Liquid Phase ◽  
Liquid Phase Separation ◽  
High Concentration ◽  
Antibody Solution ◽  
Liquid Liquid Phase Separation

scholarly journals Liquid-Liquid Phase Separation of a Monoclonal Antibody and Nonmonotonic Influence of Hofmeister Anions

2010 ◽  
Vol 99 (11) ◽  
pp. 3792-3800 ◽  
Author(s):  
Bruce D. Mason ◽  
Jian Zhang-van Enk ◽  
Le Zhang ◽  
Richard L. Remmele ◽  
Jifeng Zhang
Keyword(s):  
Monoclonal Antibody ◽  
Phase Separation ◽  
Liquid Phase ◽  
Liquid Phase Separation ◽  
Hofmeister Anions ◽  
Liquid Liquid Phase Separation

scholarly journals Liquid-Liquid Phase Separation of Tau Driven by Hydrophobic Interaction Facilitates Fibrillization of Tau

2021 ◽  
Vol 433 (2) ◽  
pp. 166731
Author(s):  
Yanxian Lin ◽  
Yann Fichou ◽  
Andrew P. Longhini ◽  
Luana C. Llanes ◽  
Pengyi Yin ◽  
...  
Keyword(s):  
Phase Separation ◽  
Liquid Phase ◽  
Hydrophobic Interaction ◽  
Liquid Phase Separation ◽  
Liquid Liquid Phase Separation
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