scholarly journals Integrating a problem-solving intervention with routine care to improve psychosocial functioning among mothers of children with sickle cell disease: A randomized controlled trial

PLoS ONE ◽  
2021 ◽  
Vol 16 (6) ◽  
pp. e0252513
Author(s):  
Monika R. Asnani ◽  
Damian Francis ◽  
Jennifer Knight-Madden ◽  
Susan Chang-Lopez ◽  
Lesley King ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Problem Solving ◽  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Treatment Effect ◽  
Effect Size ◽  
Controlled Trial ◽  
Cell Disease ◽  
Problem Solving Skills ◽  
Randomized Controlled

Objective To assess the feasibility of a problem-solving skills training intervention in improving psychological outcomes in mothers of infants with sickle cell disease (SCD). Design and methods This parallel randomized controlled trial recruited 64 babies with SCD, 6 to 12 months of age, and their mothers. Baseline measurements assessed mothers’ coping and problem-solving skills, depression, and parental stress before random assignment to intervention or control groups (n = 32 each). Problem-solving skills intervention was delivered through 6 monthly sessions, when babies attended for routine penicillin prophylaxis. All measurements were repeated for both groups at the end of the intervention period. Intention to treat analysis used repeated measures mixed models with the restricted estimation maximum likelihood approach. Results The problem-solving intervention had no significant effect on mothers’ problem-solving skills (adjusted treatment effect: -1.69 points (95% CI:-5.62 to 2.25)), coping behaviours (adjusted treatment effect: 0.65 points (95% CI:- -7.13 to 8.41)) or depressive symptoms (adjusted treatment effect: -0.41 (95% CI: -6.00 to 5.19)). It reduced mothers’ level of difficulty in managing stressful events by 9.5 points (95% CI (-16.86 to -2.16); effect size: 0.21 SD). In the subgroup of mothers at risk of depression (n = 31 at baseline), the intervention reduced depression scores with treatment effect of 10.4 points (95%CI: -18.83 to -1.88; effect size: 0.67 SD). Conclusion This problem-solving skills intervention study suggests feasibility and possible efficacy in improving some maternal outcomes. Further refinement and culturally appropriate adaptations of the intervention could lead to stronger effects.

226 Ketamine Use for Acute Painful Crisis of Sickle Cell Disease: A Randomized Controlled Trial

2019 ◽  
Vol 74 (4) ◽  
pp. S89-S90 ◽  
Author(s):  
M.S. Alshahrani ◽  
A.H. Alsulaibikh ◽  
M.M. ElTahan ◽  
S.Z. AlFaraj ◽  
A.A. AlMulhim ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Controlled Trial ◽  
Cell Disease ◽  
Randomized Controlled ◽  
Painful Crisis

scholarly journals Perception of young adults with sickle cell disease or sickle cell trait about participation in the CHOICES randomized controlled trial

2015 ◽  
Vol 72 (6) ◽  
pp. 1430-1440 ◽  
Author(s):  
Patricia E. Hershberger ◽  
Agatha M. Gallo ◽  
Robert Molokie ◽  
Alexis A. Thompson ◽  
Marie L. Suarez ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Young Adults ◽  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Sickle Cell Trait ◽  
Controlled Trial ◽  
Cell Disease ◽  
Randomized Controlled

scholarly journals Patient-controlled analgesia versus continuous infusion of morphine during vaso-occlusive crisis in sickle cell disease, a randomized controlled trial

2007 ◽  
Vol 82 (11) ◽  
pp. 955-960 ◽  
Author(s):  
Eduard J. van Beers ◽  
Charlotte F.J. van Tuijn ◽  
Pythia T. Nieuwkerk ◽  
Philip W. Friederich ◽  
Jan H. Vranken ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Sickle Cell Disease ◽  
Continuous Infusion ◽  
Sickle Cell ◽  
Controlled Trial ◽  
Cell Disease ◽  
Patient Controlled Analgesia ◽  
Randomized Controlled

scholarly journals Randomized Controlled Trial of Sildenafil for Preventing Recurrent Ischemic Priapism in Sickle Cell Disease

2014 ◽  
Vol 127 (7) ◽  
pp. 664-668 ◽  
Author(s):  
Arthur L. Burnett ◽  
Uzoma A. Anele ◽  
Irene N. Trueheart ◽  
John J. Strouse ◽  
James F. Casella
Keyword(s):  
Randomized Controlled Trial ◽  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Controlled Trial ◽  
Cell Disease ◽  
Randomized Controlled ◽  
Ischemic Priapism

scholarly journals An education session on sickle cell disease with teachers in Lagos, Nigeria: evaluation of a randomized controlled trial

2018 ◽  
Vol 5 (3) ◽  
pp. 115-124
Author(s):  
Bolanle Ola ◽  
Ayoola Olajide ◽  
Segun Olajide ◽  
Iain R. Williamson ◽  
Simon M. Dyson
Keyword(s):  
Randomized Controlled Trial ◽  
Sickle Cell Disease ◽  
Young People ◽  
Sickle Cell ◽  
Controlled Trial ◽  
Intervention Group ◽  
Sub Saharan Africa ◽  
Cell Disease ◽  
Education Session ◽  
Randomized Controlled

Sickle cell disease is a major public health issue in sub-Saharan Africa, with Nigeria having the largest absolute numbers of young people living with sickle cell disease. Research in the Global North suggests that young people with sickle cell disease are not well supported at school, whilst research in the Global South focuses on attitudes to the identification of genetic carriers to prevent births of children with sickle cell disease, rather than support of those with the sickle cell disease condition itself. Between 2015 and 2017 a randomized controlled trial based on one hour education session for school teachers, based on information contained in a guide to school policy on sickle cell disease, was conducted with 402 young people with sickle cell disease across 314 schools in Lagos State, Nigeria. Young people with sickle cell disease in both intervention group and control groups showed significant decreases in the number of days of school absence and in self-reported indicators of lack of support, and significant increases in self-reported indicators of school support. The results suggest a breakdown of the randomization, probably because the young people with sickle cell disease all reacted positively to researchers taking an interest in their welfare in a context where they would usually be heavily stigmatized and would be inclined to hide their sickle cell disease status from others at school. In conclusion, conditions conducive to conducting successful research on sickle cell disease in this context - increased self-esteem in young people with sickle cell disease, reduction in within-school stigmatizing attitudes, and commitment by policy makers to improve the situation of young people in schools – are the very factors that would improve the experiences of young people living with sickle cell disease at school in Lagos, Nigeria. The fact that positive changes did occur warrants further research on this topic.

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