scholarly journals OCTAVA: An open-source toolbox for quantitative analysis of optical coherence tomography angiography images

PLoS ONE ◽  
2021 ◽  
Vol 16 (12) ◽  
pp. e0261052
Author(s):  
Gavrielle R. Untracht ◽  
Rolando S. Matos ◽  
Nikolaos Dikaios ◽  
Mariam Bapir ◽  
Abdullah K. Durrani ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Quantitative Analysis ◽  
Open Source ◽  
Optical Coherence Tomography Angiography ◽  
Microvascular Disease ◽  
Maximum Intensity Projection ◽  
Optical Coherence ◽  
Definition Of ◽  
User Friendly

Optical coherence tomography angiography (OCTA) performs non-invasive visualization and characterization of microvasculature in research and clinical applications mainly in ophthalmology and dermatology. A wide variety of instruments, imaging protocols, processing methods and metrics have been used to describe the microvasculature, such that comparing different study outcomes is currently not feasible. With the goal of contributing to standardization of OCTA data analysis, we report a user-friendly, open-source toolbox, OCTAVA (OCTA Vascular Analyzer), to automate the pre-processing, segmentation, and quantitative analysis of en face OCTA maximum intensity projection images in a standardized workflow. We present each analysis step, including optimization of filtering and choice of segmentation algorithm, and definition of metrics. We perform quantitative analysis of OCTA images from different commercial and non-commercial instruments and samples and show OCTAVA can accurately and reproducibly determine metrics for characterization of microvasculature. Wide adoption could enable studies and aggregation of data on a scale sufficient to develop reliable microvascular biomarkers for early detection, and to guide treatment, of microvascular disease.

scholarly journals Quantitative analysis of choriocapillaris in non-human primates using swept-source optical coherence tomography angiography (SS-OCTA)

2018 ◽  
Vol 10 (1) ◽  
pp. 356 ◽  
Author(s):  
Bingyao Tan ◽  
Jacqueline Chua ◽  
Veluchamy Amutha Barathi ◽  
Mani Baskaran ◽  
Anita Chan ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Quantitative Analysis ◽  
Optical Coherence Tomography Angiography ◽  
Optical Coherence ◽  
Swept Source

scholarly journals Characterization of microvascular tortuosity in retinal vein occlusion utilizing optical coherence tomography angiography

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Hyungwoo Lee ◽  
Myung Ae Kim ◽  
Hyung Chan Kim ◽  
Hyewon Chung
Keyword(s):  
Optical Coherence Tomography ◽  
Retinal Vein Occlusion ◽  
Optical Coherence Tomography Angiography ◽  
Branch Length ◽  
Optical Coherence ◽  
Branch Number ◽  
Affected Area ◽  
Vein Occlusion ◽  
Capillary Plexus

Abstract We investigated the characteristics of microvessel tortuosity in branch retinal vein occlusion (BRVO) and central retinal vein occlusion (CRVO) and their associations with visual outcomes using optical coherence tomography angiography (OCTA). Thirty-four BRVO and 21 CRVO patients and 31 healthy subjects were included. From OCTA, the branch number (BN), mean branch length (BL), mean Euclidean length (EL), vessel density (VD) and vessel tortuosity (VT) were quantified. In BRVO eyes, compared with that in the controls, the affected area of the deep capillary plexus (DCP) showed a decreased BN and VD, an increased BL, and unchanged VT. The nonaffected area of the DCP showed decreases in BN, VD and VT. The affected area of the superficial capillary plexus (SCP) showed higher VT. In CRVO eyes, the DCP showed a lower BN, VD and VT, while the SCP showed a lower BN and greater BL and EL. Improved visual acuity (VA) after 1 year in BRVO eyes was associated with decreases in BN, BL, VD and VT in the affected area in the DCP and lower VT in the nonaffected area of the SCP; in CRVO eyes, improved VA was associated with a higher BL and EL in the DCP. VT, BL, and EL may be new microvascular markers associated with changes in VA in BRVO and CRVO.

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