scholarly journals Gastric motility and pulmonary function in children with functional abdominal pain disorders and asthma: A pathophysiological study

PLoS ONE ◽  
2022 ◽  
Vol 17 (1) ◽  
pp. e0262086
Author(s):  
Manori Vijaya Kumari ◽  
Lakmali Amarasiri ◽  
Shaman Rajindrajith ◽  
Niranga Manjuri Devanarayana
Keyword(s):  
Abdominal Pain ◽  
Lung Function ◽  
Pulmonary Function ◽  
Gastric Motility ◽  
Study Groups ◽  
Airflow Limitation ◽  
Functional Abdominal Pain ◽  
Motility Index ◽  
Antral Motility ◽  
Children With Asthma

Background An association has been shown between functional abdominal pain disorders (FAPDs) and asthma. However, the exact reason for this association is obscured. The main objective of this study is to identify the possible underlying pathophysiological mechanisms for the association between FAPDs and asthma using gastric motility and lung function tests. Methods This was a cross-sectional comparative study that consisted of four study groups. Twenty-four children (age 7–12 years) each were recruited for four study groups; asthma only, FAPDs only, both asthma and FAPDs, and healthy controls. Asthma was diagnosed using the history and bronchodilator reversibility test. The diagnosis of FAPDs was made using Rome IV criteria. All subjects underwent ultrasound assessment of gastric motility and pulmonary function assessment by spirometry, using validated techniques. Results All gastric motility parameters, gastric emptying rate, amplitude of antral contraction, and antral motility index, were significantly impaired in children with FAPDs only, children with asthma only, and children with both asthma & FAPDs, compared to controls (p<0.05). Pulmonary function parameters indicating airway obstruction (FEV1/FVC ratio, peak expiratory flow rate, FEF25-75%) were not impaired in children with FAPDs only compared to controls (p>0.05), but significantly impaired in children with asthma and children with both disorders. Antral motility index correlated with the FEV1/FVC ratio (r = 0.60, p = 0.002) and FEF25%-75% (r = 0.49, p = 0.01) in children with both asthma and FAPDs. Conclusions Gastric motor functions were significantly impaired in children with asthma, children with FAPDs, and children with both disorders. Motility index, measuring overall gastric motor activity, showed a significant positive correlation with lung function parameters that measure airflow limitation. Therefore, these diseases might arise as a result of primary disturbance of smooth muscle activity in the airways and gastrointestinal wall, which could be a possible pathophysiological mechanism for this association between asthma and FAPDs.

scholarly journals Pulmonary involvement in Fabry disease: effect of plasma globotriaosylsphingosine and time to initiation of enzyme replacement therapy

2018 ◽  
Vol 5 (1) ◽  
pp. e000277 ◽  
Author(s):  
Daniel Franzen ◽  
Sarah R Haile ◽  
David C Kasper ◽  
Thomas P Mechtler ◽  
Andreas J Flammer ◽  
...  
Keyword(s):  
Lung Function ◽  
Enzyme Replacement Therapy ◽  
Pulmonary Function ◽  
Fabry Disease ◽  
Replacement Therapy ◽  
Pulmonary Function Tests ◽  
Airflow Limitation ◽  
Z Score ◽  
Lung Function Decline ◽  
Enzyme Replacement

IntroductionAnderson-Fabry disease (AFD) is an X-linked lysosomal storage disorder caused by mutations of GLA gene leading to reduced α-galactosidase activity and resulting in a progressive accumulation of globotriaosylceramide (Gb3) and its deacylated derivative, globotriaosyl-sphingosine (Lyso-Gb3). Plasma Lyso-Gb3 levels serve as a disease severity and treatment monitoring marker during enzyme replacement therapy (ERT).MethodsAdult patients with AFD who had yearly pulmonary function tests between 1999 and 2015 were eligible for this observational study. Primary outcome measures were the change in z-score of forced expiratory volume in the first second (FEV1) and FEV1/FVC over time. Plasma Lyso-Gb3 levels and the age of ERT initiation were investigated for their association with lung function decline.ResultsFifty-three patients (42% male, median (range) age at diagnosis of AFD 34 (6–61) years in men, 34 (13–67) in women) were included. The greatest decrease of FEV1/FVC z-scores was observed in Classic men (−0.048 per year, 95% CI −0.081 to –0.014), compared with the Later-Onset men (+0.013,95% CI −0.055 to 0.082), Classic women (−0.008, 95% CI −0.035 to +0.020) and Later-Onset women (−0.013, 95% CI −0.084 to +0.058). Cigarette smoking (P=0.022) and late ERT initiation (P=0.041) were independently associated with faster FEV1 decline. FEV1/FVC z-score decrease was significantly reduced after initiation of ERT initiation (−0.045 compared with −0.015, P=0.014). Furthermore, there was a trend towards a relevant influence of Lyso-Gb3 (P=0.098) on airflow limitation with age.ConclusionEarly ERT initiation seems to preserve pulmonary function. Plasma Lyso-Gb3 is maybe a useful predictor for airflow limitation. Classic men need a closer monitoring of the lung function.

scholarly journals Autonomic functions and gastric motility in children with functional abdominal pain disorders

2019 ◽  
Vol 25 (1) ◽  
pp. 95-106 ◽  
Author(s):  
Amaranath Karunanayake ◽  
Shaman Rajindrajith ◽  
Hitanadura Asita de Silva ◽  
Sampath Gunawardena ◽  
Niranga Manjuri Devanarayana
Keyword(s):  
Abdominal Pain ◽  
Gastric Motility ◽  
Functional Abdominal Pain ◽  
Autonomic Functions

Effects of gastric pacing on canine gastric motility and emptying

1993 ◽  
Vol 265 (4) ◽  
pp. G767-G774 ◽  
Author(s):  
J. C. Eagon ◽  
K. A. Kelly
Keyword(s):  
Gastric Emptying ◽  
Gastric Motility ◽  
Contractile Activity ◽  
Lag Phase ◽  
Motility Index ◽  
Bipolar Electrodes ◽  
Gastric Pacing ◽  
Antral Motility ◽  
Pacesetter Potentials ◽  
Potential Frequency

Gastric pacing has been achieved in dogs and humans, but its effects on gastric motility and emptying have not been thoroughly explored. Seven dogs had bipolar electrodes placed 1 and 10 cm proximal to the pylorus for reverse and forward pacing and monopolar recording electrodes and strain gauges placed 3, 5, and 7 cm proximal to the pylorus. After recovery, myoelectrical and contractile activity and gastric emptying of a mixed meal (50 g 99mTc-labeled liver and 250 ml 111In-labeled 5% dextrose broth solution) were measured in each of three conditions: no pacing, reverse pacing, and forward pacing (frequency 0.5 cycles/min above intrinsic pacesetter potential frequency). Reverse pacing reversed the direction of > 90% of antral pacesetter potentials and peristaltic waves in six of seven dogs, prolonged the lag phase of solid emptying, prolonged the half emptying time of solids and liquids, and increased the antral motility index. Forward pacing entrained pacesetter potentials but had no consistent effect on emptying or antral contractions. In conclusion, reverse gastric pacing slows gastric emptying of digestible solids and liquids by reversing the direction of antral peristalsis and increasing the antral motility index, whereas forward pacing has no such effects.

Sa390 4D CINE-MRI-DERIVED GASTRIC MOTILITY INDEX IS ASSOCIATED WITH REPORTED ABDOMINAL PAIN IN PATIENTS WITH FUNCTIONAL DYSPEPSIA

2021 ◽  
Vol 160 (6) ◽  
pp. S-488
Author(s):  
Roberta Sclocco ◽  
Christopher Nguyen ◽  
Rowan Staley ◽  
Harrison P. Fisher ◽  
April Mendez ◽  
...  
Keyword(s):  
Abdominal Pain ◽  
Functional Dyspepsia ◽  
Gastric Motility ◽  
Cine Mri ◽  
Motility Index

Treating Functional Abdominal Pain Disorders in Children through a Guided Imagery Therapy Mobile Application: Formative Research

2017 ◽  
Author(s):  
John M Hollier ◽  
Adetola O Vaughan ◽  
Yan Liu ◽  
Miranda A.L. van Tilburg ◽  
Robert J. Shulman ◽  
...  
Keyword(s):  
Abdominal Pain ◽  
Mobile Application ◽  
Guided Imagery ◽  
Formative Research ◽  
Functional Abdominal Pain

Effects of Dingchuan Decoction on Lung Function and Clinical Effectiveness Rate in Children with Asthma: A Systematic Review and Meta-Analysis

2021 ◽  
pp. 1-12
Author(s):  
Sheng-Nan Wang ◽  
Jia-Li Yan ◽  
Shao-Xing Wu ◽  
Lei Wu ◽  
Yan-Chan Zheng ◽  
...  
Keyword(s):  
Lung Function ◽  
Randomized Controlled Trials ◽  
Large Scale ◽  
Clinical Effectiveness ◽  
Controlled Trials ◽  
Improvement Rate ◽  
Randomized Controlled ◽  
Conventional Medication ◽  
Effectiveness Rate ◽  
Children With Asthma

Dingchuan decoction (DCD) is a traditional Chinese prescription for asthma that remains popular today. To systematically evaluate the effect of DCD on lung function, clinical effectiveness rate, and safety in children with asthma, significant databases were searched for randomized controlled trials from their inception to September 9, 2019. Randomized controlled trials assessing the effect of DCD on lung function and clinical effectiveness rate in children with asthma were included in this meta-analysis. The methodological quality of the included trials was assessed using the Cochrane risk of bias tool. RevMan 5.3 was used for data analysis. Fourteen studies with 1,384 children were reviewed. FEV<sub>1</sub> improvement rate (mean difference [MD] 12.50, 95% confidence interval [CI] 8.72–16.29), PEF improvement rate (MD 14.28, 95% CI 11.08–17.49), and clinical effectiveness rate (relative risk 1.19, 95% CI 1.14–1.25) significantly increased in the DCD group when compared to simple conventional medication. Four trials suggest that DCD is safe for children. In conclusion, the use of DCD combined with conventional medication improves lung function and clinical effectiveness rate better than simple conventional medication. However, the selected trials lack blinding and large-scale studies. Therefore, to better manage DCD in clinical practice, more randomized controlled trials and large-scale studies are required for further evaluation.

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