Septic Shock, Multiple Organ Failure, and Disseminated Intravascular Coagulation

CHEST Journal ◽  
1992 ◽  
Vol 101 (3) ◽  
pp. 816-823 ◽  
Author(s):  
Francois Fourrier ◽  
Claude Chopin ◽  
Jenny Goudemand ◽  
Sylvie Hendrycx ◽  
Claudine Caron ◽  
...  
Keyword(s):  
Septic Shock ◽  
Multiple Organ Failure ◽  
Organ Failure ◽  
Disseminated Intravascular Coagulation ◽  
Multiple Organ ◽  
Intravascular Coagulation

scholarly journals COVID-19, septic shock and syndrome of disseminated intravascular coagulation syndrome. Part 1

2020 ◽  
Author(s):  
Victoria O. Bitsadze ◽  
Jamilya Kh. Khizroeva ◽  
Alexander Makatsariya ◽  
Ekaterina V Slukhanchuk ◽  
Maria V Tretyakova ◽  
...  
Keyword(s):  
Septic Shock ◽  
Systemic Inflammatory Response Syndrome ◽  
Inflammatory Response ◽  
Multiple Organ Failure ◽  
Organ Failure ◽  
Disseminated Intravascular Coagulation ◽  
Critical Condition ◽  
Multiple Organ ◽  
Systemic Inflammatory Response ◽  
Intravascular Coagulation

The pandemic of a new coronavirus infection (Coronavirus Disease 2019, COVID-19) caused by SARS-CoV-2 became a real challenge to humanity and the medical community in 2020 and raised a number of medical, social and even philosophical questions. An almost avalanche-like increase in the number of infected people in a short time, due to the high contagiousness of viral infection, allowed us to identify groups of patients with mild, moderate and severe forms of the disease. Doctors around the world are faced with an acute problem of treating a large number of patients in critical conditions caused by COVID-19. From the currently available information on clinical cases of COVID-19, it follows that COVID-19 patients in critical condition have a clinical picture of disseminated intravascular coagulation (DIC), septic shock with the development of multiple organ failure. The first part of the article discusses the pathogenesis of non-specific universal biological responses of the body in critical condition - from the Sanarelli-Schwartzman phenomenon to the DIC, septic shock, systemic inflammatory response syndrome and the so-called neutrophil extracellular traps (NETs). The questions of cytokine storm in severe forms of systemic inflammatory response syndrome (SIRS), the role of inflammation in the activation of coagulation, and the relationship between inflammation and thrombosis are discussed. Modern ideas about the mechanisms of so-called NETosis, their role in the occurrence of immunothrombosis and inflammation-induced thrombosis in autoimmune diseases - vasculitis, antiphospholipid syndrome, and systemic lupus erythematosus is highlighted. The article discusses the possibility of participation of ADAMTS-13 metalloproteinase in the pathogenesis of multiple organ failure in severe endotheliopathy in patients with viral septic shock.

Low molecular weight heparin attenuates multiple organ failure in a murine model of disseminated intravascular coagulation*

2005 ◽  
Vol 33 (6) ◽  
pp. 1365-1370 ◽  
Author(s):  
Sjoukje H. Slofstra ◽  
Cornelis van ’t Veer ◽  
Wim A. Buurman ◽  
Pieter H. Reitsma ◽  
Hugo ten Cate ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Multiple Organ Failure ◽  
Organ Failure ◽  
Disseminated Intravascular Coagulation ◽  
Murine Model ◽  
Low Molecular Weight Heparin ◽  
Multiple Organ ◽  
Low Molecular Weight ◽  
Intravascular Coagulation

Sepsis model with reproducible manifestations of multiple organ failure (MOF) and disseminated intravascular coagulation (DIC)

1989 ◽  
Vol 54 (1) ◽  
pp. 53-61 ◽  
Author(s):  
T. Tanaka ◽  
T. Tsujinaka ◽  
J. Kambayashi ◽  
M. Higashiyama ◽  
M. Sakon ◽  
...  
Keyword(s):  
Multiple Organ Failure ◽  
Organ Failure ◽  
Disseminated Intravascular Coagulation ◽  
Multiple Organ ◽  
Intravascular Coagulation ◽  
Sepsis Model

The effect of heparin on multiple organ failure and disseminated intravascular coagulation in a sepsis model

1990 ◽  
Vol 60 (4) ◽  
pp. 321-330 ◽  
Author(s):  
Toshikazu Tanaka ◽  
Toshimasa Tsujinaka ◽  
Jun-ichi Kambayashi ◽  
Masahiko Higashiyama ◽  
Masayuki Yokota ◽  
...  
Keyword(s):  
Multiple Organ Failure ◽  
Organ Failure ◽  
Disseminated Intravascular Coagulation ◽  
Multiple Organ ◽  
Intravascular Coagulation ◽  
Sepsis Model
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