THE IMPACT OF INCLUDING A PHYSICIAN ALERT ACCOMPANYING PULMONARY FUNCTION (PFT) RESULTS ON TESTING FOR AND DETECTION OF ALPHA-1 ANTITRYPSIN DEFICIENCY

CHEST Journal ◽  
2007 ◽  
Vol 132 (4) ◽  
pp. 523C ◽  
Author(s):  
Franck F. Rahaghi ◽  
Ismael Ortega ◽  
Deborah Schrager ◽  
Terre Schott ◽  
Eduardo Oliveira ◽  
...  
Keyword(s):  
Pulmonary Function ◽  
Antitrypsin Deficiency ◽  
Alpha 1 Antitrypsin Deficiency ◽  
Alpha 1 Antitrypsin ◽  
The Impact

Small airway evaluation in three subjects with alpha-1 antitrypsin deficiency without diagnosed lung disease

2021 ◽  
Vol 14 (3) ◽  
pp. e239146
Author(s):  
Thais Ferrari da Cruz ◽  
Rogério Rufino ◽  
Agnaldo Lopes ◽  
Cláudia Henrique Costa
Keyword(s):  
Pulmonary Function ◽  
Pulmonary Function Tests ◽  
Genetic Disorder ◽  
Early Investigation ◽  
Small Airways ◽  
Nitrogen Washout ◽  
Function Tests ◽  
Antitrypsin Deficiency ◽  
Alpha 1 Antitrypsin Deficiency ◽  
Alpha 1 Antitrypsin

We describe three cases of female subjects (aged 16, 44 and 41 years) with no respiratory symptoms, who have alpha-1 antitripsyn mutation (PiSZ, PiZZ and PiZZ) and who performed traditional pulmonary function tests and the single breath nitrogen washout test. They still did not have chronic obstructive pulmonary disease (COPD) or any identifiable change in traditional pulmonary function tests but already have change in nitrogen washout tests. Alpha-1 antitrypsin deficiency is a genetic disorder associated with early-onset COPD. There is evidence that although patients who have well-preserved FEV1 may already have signs of emphysema associated with symptoms. Therefore, the nitrogen washout test is considered to have more sensitive outcomes than other pulmonary function tests for early investigation of small airways disease and could allow the monitoring pulmonary function and evaluating of therapeutic decision.

Stem Cell Therapies in Reparative Medicine

2003 ◽  
Vol 12 (4) ◽  
pp. 329-334 ◽  
Author(s):  
Juan Domínguez-Bendala ◽  
Camillo Ricordi
Keyword(s):  
Developmental Biology ◽  
Stem Cell ◽  
Logical Consequence ◽  
Stem Cell Therapies ◽  
Cell Therapies ◽  
Novel Technologies ◽  
Antitrypsin Deficiency ◽  
Alpha 1 Antitrypsin Deficiency ◽  
Alpha 1 Antitrypsin ◽  
The Impact

The future implementation of stem cell therapies to treat conditions thus far considered incurable has been envisioned as logical consequence of the fast-paced progress in stem cell research over the last few years. Still, many practical obstacles stand in the way to the routine application of these novel technologies in medicine. The conference “Stem Cell Therapies in Reparative Medicine,” held aboard the cruise vessel Majesty of the Seas (Miami, USA- Nassau, Bahamas, April 19–22, 2002), focused on the analysis of these problems from different perspectives, including developmental biology (cell proliferation, fate determination, and enrichment), immunology (allorejection and prevention of autoimmunity recurrence), and clinical therapy, emphasizing the impact of stem cell technologies on the emerging field of tissue engineering and the treatment of alpha-1 antitrypsin deficiency.

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