Prognostic Accuracy of Clinical Prediction Rules for Early Post-Pulmonary Embolism All-Cause Mortality

CHEST Journal ◽  
2015 ◽  
Vol 147 (4) ◽  
pp. 1043-1062 ◽  
Author(s):  
Christine G. Kohn ◽  
Elizabeth S. Mearns ◽  
Matthew W. Parker ◽  
Adrian V. Hernandez ◽  
Craig I. Coleman
2019 ◽  
Vol 20 (3) ◽  
pp. 281-285
Author(s):  
Dragan Panic ◽  
Andreja Todorovic ◽  
Milica Stanojevic ◽  
Violeta Iric Cupic

Abstract Current diagnostic workup of patients with suspected acute pulmonary embolism (PE) usually starts with the assessment of clinical pretest probability, using clinical prediction rules and plasma D-dimer measurement. Although an accurate diagnosis of acute pulmonary embolism (PE) in patients is thus of crucial importance, the diagnostic management of suspected PE is still challenging. A 60-year-old man with chest pain and expectoration of blood was admitted to the Department of Cardiology, General Hospital in Cuprija, Serbia. After physical examination and laboratory analyses, the diagnosis of Right side pleuropne monia and acute pulmonary embolism was established. Clinically, patient was hemodynamically stable, auscultative slightly weaker respiratory sound right basal, without pretibial edema. Laboratory: C-reactive protein (CRP) 132.9 mg/L, Leukocytes (Le) 18.9x109/L, Erythrocytes (Er) 3.23x1012/L, Haemoglobin (Hgb) 113 g/L, Platelets (Plt) 79x109/L, D-dimer 35.2. On the third day after admission, D-dimer was increased and platelet count was decreased (Plt up to 62x109/L). According to Wells’ rules, score was 2.5 (without symptoms on admission), a normal clinical finding with clinical manifestation of hemoptysis and chest pain, which represents the intermediate level of clinical probability of PE. After the recidive of PE, Wells’ score was 6.5. In summary, this study suggests that Wells’ score, based on a patient’s risk for pulmonary embolism, is a valuable guidance for decision-making in combination with knowledge and experience of clinicians. Clinicians should use validated clinical prediction rules to estimate pretest probability in patients in whom acute PE is being consiered.


2002 ◽  
Vol 113 (4) ◽  
pp. 269-275 ◽  
Author(s):  
Isabelle Chagnon ◽  
Henri Bounameaux ◽  
Drahomir Aujesky ◽  
Pierre-Marie Roy ◽  
Anne-Laurence Gourdier ◽  
...  

ESC CardioMed ◽  
2018 ◽  
pp. 2758-2761
Author(s):  
Piotr Pruszczyk

Clinical manifestations of venous thromboembolism (VTE) usually are non-specific. In order to facilitate proper diagnosis, clinical prediction rules were derived. The best studied models are the Wells criteria for deep vein thrombosis and pulmonary embolism and the Geneva score for pulmonary embolism. They classify patients into different categories of clinical pretest VTE probability. Pulmonary embolism prevalence is approximately 10% in low-, 30% in moderate-, and up to 65% in high-probability categories. Plasma D-dimer levels are elevated in not only VTE but also in other conditions. A D-dimer assay should be used in combination with pretest VTE clinical probability. A normal high-sensitivity D-dimer level excludes pulmonary embolism in patients with low/intermediate or non-high VTE probability, while in the high probability category does not allow VTE to be safely excluded. Age-adjusted D-dimer thresholds (age × 10 μ‎g/L above 50 years) can limit the need for imaging methods without increasing the rate of missed diagnoses in non-high clinical probability patients.


2012 ◽  
Vol 130 ◽  
pp. S125
Author(s):  
Alessandro Squizzato ◽  
Marco P. Donadini ◽  
Luca Galli ◽  
Francesco Dentali ◽  
Drahomir Aujesky ◽  
...  

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