Moduretic administration in salt-induced hypertension: cardiovascular response

WA Saka; EA Ashamu; OO Ogundipe; RE Akhigbe; FM Moronkeji; OO Akintoye

doi:10.14194/ijep.2.1.1

Moduretic administration in salt-induced hypertension: cardiovascular response

International Journal of Ethnomedicine and Pharmacognosy ◽

10.14194/ijep.2.1.1 ◽

2015 ◽

Vol 2 (1) ◽

pp. 1-5

Author(s):

WA Saka ◽

EA Ashamu ◽

OO Ogundipe ◽

RE Akhigbe ◽

FM Moronkeji ◽

...

Keyword(s):

Cardiovascular Response ◽

Induced Hypertension

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ACTH-induced hypertension in rats: fact or artifact?

AJP Regulatory Integrative and Comparative Physiology ◽

10.1152/ajpregu.1989.256.6.r1308 ◽

1989 ◽

Vol 256 (6) ◽

pp. R1308-R1312 ◽

Cited By ~ 3

Author(s):

K. A. Gruber ◽

S. L. Eskridge-Sloop ◽

J. C. Eldridge ◽

M. F. Callahan

Keyword(s):

Arterial Pressure ◽

Adrenocorticotropic Hormone ◽

Cardiovascular Response ◽

Diuretic Effect ◽

Indirect Approach ◽

Acth Treatment ◽

Induced Hypertension ◽

Arterial Pressure Measurement ◽

Depot Injection ◽

Tail Cuff

Evidence from numerous laboratories has shown that administration of adrenocorticotropic hormone (ACTH) to rats produces hypertension within 5 days. However, the analysis of blood pressure in these studies was by the tail-cuff technique, an acute and indirect approach. We have now administered ACTH, via a subcutaneous depot injection (5 or 10 U/day for 9 days), to chronically instrumented rats maintained in metabolic cages. Although tail-cuff measurements of arterial pressure indicated that the ACTH treatment produced hypertension, this was not confirmed by direct 24-h measurements of mean arterial pressure. There was no effect of ACTH on 24-h heart rate throughout the treatment period compared with saline-injected controls. We also examined coefficient of variation of all our measurements. None of the factors was altered by ACTH administration. However, ACTH treatment did produce a diuretic effect, further confirming previous work and providing renal, in addition to cardiovascular, evidence for the bioavailability of the ACTH depot. These results demonstrate that chronic ACTH treatment does not produce a true hypertensive state in rats but rather may enhance the cardiovascular response to the stress of the indirect arterial pressure measurement technique.

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Effects of Physical Training on Stuttering

Journal of Speech and Hearing Research ◽

10.1044/jshr.1104.767 ◽

1968 ◽

Vol 11 (4) ◽

pp. 767-776 ◽

Cited By ~ 2

Author(s):

B. Don Franks ◽

Elizabeth B. Franks

Keyword(s):

College Students ◽

Group Therapy ◽

Physical Training ◽

Cardiovascular Response ◽

Training Group ◽

Physical Stress ◽

Submaximal Exercise ◽

Endurance Running ◽

Response To Exercise

Eight college students enrolled in group therapy for stuttering were divided into two equal groups for 20 weeks. The training group supplemented therapy with endurance running and calisthenics three days per week. The subjects were tested prior to and at the conclusion of the training on a battery of stuttering tests and cardiovascular measures taken at rest, after stuttering, and after submaximal exercise. There were no significant differences (0.05 level) prior to training. At the conclusion of training, the training group was significandy better in cardiovascular response to exercise and stuttering. Although physical training did not significantly aid the reduction of stuttering as measured in this study, training did cause an increased ability to adapt physiologically to physical stress and to the stress of stuttering.

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