Synthesis, Characterization and in vitro Anticancer Studies of New Co(II), Ni(II), Cu(II) and
Zn(II) Complexes of (E)-4-((Quinoline-8-ylimino)methyl)benzene-1,2,3-triol Ligand

Herein, a new tridentate (NNO) Schiff base ligand, (E)-4-[(quinoline-8-ylimino)methyl]benzene-1,2,3- triol derived from the condensation of 8-aminoquinoline with 2,3,4-trihydroxy benzaldehyde is reported. The ligand was complexed with certain metal ions like Co(II) (1), Ni(II) (2), Cu(II) (3), Zn(II) (4) and were characterized by various spectroscopic and analytical techniques such as FT-IR, UV-Vis, 1H NMR, 13C NMR, ESI-Mass, ESR, elemental analysis and magnetic susceptibility. Spectral data revealed octahedral geometry for cobalt(II), nickel(II), copper(II) complexes and tetrahedral geometry for zinc(II) complex. All the metal(II) complexes along with the Schiff base ligand were screened for their anticancer activities. The CT-DNA binding studies revealed high binding propensity for metal complexes with Kb values 1.50 × 104 M-1 for 1; 3.62 × 104 M-1 for 2; 2.53 × 104 M-1 for 3 and 1.8 × 104 M-1 for 4, respectively. Anticancer studies against A549 & MCF-7 demonstrated excellent antiproliferative activity with IC50 values in the range 17.62-48.82 μM. A standard drug cisplatin was employed to compare the activity of metal complexes. The complexes exhibited remarkable antitumour activity due to their high binding ability with DNA. It is interesting to observe that the complexes did not produce any cytotoxicity towards the normal cell lines.

Download Full-text

Synthesis and DNA binding studies of Ni(II), Co(II), Cu(II) and Zn(II) metal complexes of N1,N5-bis[pyridine-2-methylene]-thiocarbohydrazone Schiff-base ligand

Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy ◽

10.1016/j.saa.2011.04.018 ◽

2011 ◽

Vol 79 (5) ◽

pp. 1050-1056 ◽

Cited By ~ 52

Author(s):

A.D. Tiwari ◽

A.K. Mishra ◽

S.B. Mishra ◽

B.B. Mamba ◽

B. Maji ◽

...

Keyword(s):

Schiff Base ◽

Dna Binding ◽

Metal Complexes ◽

Schiff Base Ligand ◽

Binding Studies ◽

Dna Binding Studies

Download Full-text

Synthesis, Characterization, Biological Activity and DNA Binding Studies of Metal Complexes with 4-Aminoantipyrine Schiff Base Ligand

E-Journal of Chemistry ◽

10.1155/2012/291850 ◽

2012 ◽

Vol 9 (1) ◽

pp. 389-400 ◽

Cited By ~ 8

Author(s):

B. Anupama ◽

M. Padmaja ◽

C. Gyana Kumari

Keyword(s):

Schiff Base ◽

Transition Metal ◽

Metal Complexes ◽

Transition Metal Complexes ◽

Schiff Base Ligand ◽

Metal Ion ◽

Spectral Studies ◽

Significant Activity ◽

Central Metal ◽

Binding Studies

A new series of transition metal complexes of Cu(II),Ni(II),Co(II), Zn(II) and VO(IV) have been synthesized from the Schiff base ligand (L) derived from 4-amino antipyrine and 5- bromo salicylaldehyde. The structural features of Schiff base and metal complexes were determined from their elemental analyses, thermogravimetric studies, magneticsusceptibility, molar conductivity, ESI-Mass, IR, UV-VIS,1H NMR and ESR spectral studies. The data show that the complexes have composition of ML2type. The UV-VIS, magnetic susceptibility and ESR spectral data suggest an octahedral geometry around the central metal ion. Biological screening of the complexes reveals that the Schiff base transition metal complexes show significant activity against microorganisms. Binding of Co(II) complex with calf thymus DNA (CT DNA) was studied by spectral methods.

Download Full-text

Novel Cr(III), Co(II), Zn(II) and Cd(II) Complexes of Schiff Base Ligand Derived from Salicyaldehyde and 3,4-Diaminotoluene: Synthesis, Characterization and Biological Screening

Asian Journal of Chemistry ◽

10.14233/ajchem.2020.22544 ◽

2020 ◽

Vol 32 (5) ◽

pp. 1091-1096

Author(s):

Netra Pal Singh ◽

Uma Agarwal ◽

Anuroop Kumar ◽

Kaushal Kumar

Keyword(s):

Schiff Base ◽

Metal Complexes ◽

Schiff Base Ligand ◽

Conductivity Measurement ◽

Chelating Agent ◽

Molar Ratio ◽

Spectral Studies ◽

Tetrahedral Geometry ◽

Antibacterial And Antifungal

A new Schiff base ligand (L) [2,2′-((1Z,1′Z)-((4-methyl-1,2- phenylene)bis(azanylidene))bis(methanylylidene))diphenol], derived from condensation of salicyaldehyde and 3,4-diamino toluene. The synthesized ligand was used for complexation with different metal ions Cr(III), Co(II), Zn(II) and Cd(II) using a molar ratio of metal:ligand (1:1). The synthesized ligand and its metal complexes were characterized by TLC, NMR (1H & 13C), UV-visible, mass, FT-IR spectroscopies, elemental analysis, magnetic moment and conductivity measurement. On the basis of above studies the proposed structure of synthesized mononuclear metal complexes have been found to possess tetrahedral geometry while Cr(III) and Co(II) ions possess octahedral geometry. The spectral studies revealed that the synthesized ligand was acting as tetradentate chelating agent and coordinated to metal centre via deprotonated phenolate oxygen and azomethine-N atom. The biological activity of ligand and its metal complexes were screened in vitro against Gram-negative bacteria (Salmonella typhimurium and E. coli), Gram-positive bacteria (Staphylococcus aureus and Bacillus subtilis) and fungus (Aspergillus fumigatus) to ascertain their antibacterial and antifungal properties.

Download Full-text

Synthesis, Characterization, and Biological Activity of Some Transition Metal Complexes Derived from Novel Hydrazone Azo Schiff Base Ligand

International Journal of Inorganic Chemistry ◽

10.1155/2011/493942 ◽

2011 ◽

Vol 2011 ◽

pp. 1-8 ◽

Cited By ~ 6

Author(s):

C. Anitha ◽

S. Sumathi ◽

P. Tharmaraj ◽

C. D. Sheela

Keyword(s):

Schiff Base ◽

Metal Complexes ◽

Schiff Base Ligand ◽

Second Harmonic ◽

Biological Activities ◽

Diffusion Method ◽

Spectral Studies ◽

Planar Geometry ◽

Conductivity Measurements ◽

Tetrahedral Geometry

A series of metal(II) complexes ML where M = VO(II), Co(II), Ni(II), Cu(II), and Zn(II) have been synthesized from azo Schiff base ligand (N′E)-N′-(5-((4-chlorophenyl)diazenyl)-2-hydroxybenzylidene)-2-hydroxybenzohydrazide and characterized on the basis of elemental analyses, electronic, IR, and 1H NMR spectra, magnetic susceptibility and also by aid of scanning electron microscopy (SEM), X-ray powder diffraction, fluorescence spectral studies, and molar conductivity measurements. Conductivity measurements reveal that the complexes are nonelectrolytes. Spectroscopy and other analytical studies reveal distorted square planar geometry for copper, square-pyramidal geometry for oxovanadium, and tetrahedral geometry for other complexes. Redox behavior of the copper(II) complex has been studied with cyclic voltammetry, and the biological activities of the ligand and metal complexes have been studied against several microorganisms by the well diffusion method. All synthesized compounds can serve as potential photoactive materials as indicated from their characteristic fluorescence properties. The second harmonic generation (SHG) efficiency of the ligand was measured and found to be higher than that of urea and KDP. The SEM image of the copper(II) complex implies that the size of the particles is 50 nm.

Download Full-text