Synthesis, Characterization and in vitro Anticancer Studies of New Co(II), Ni(II), Cu(II) and Zn(II) Complexes of (E)-4-((Quinoline-8-ylimino)methyl)benzene-1,2,3-triol Ligand

Herein, a new tridentate (NNO) Schiff base ligand, (E)-4-[(quinoline-8-ylimino)methyl]benzene-1,2,3- triol derived from the condensation of 8-aminoquinoline with 2,3,4-trihydroxy benzaldehyde is reported. The ligand was complexed with certain metal ions like Co(II) (1), Ni(II) (2), Cu(II) (3), Zn(II) (4) and were characterized by various spectroscopic and analytical techniques such as FT-IR, UV-Vis, 1H NMR, 13C NMR, ESI-Mass, ESR, elemental analysis and magnetic susceptibility. Spectral data revealed octahedral geometry for cobalt(II), nickel(II), copper(II) complexes and tetrahedral geometry for zinc(II) complex. All the metal(II) complexes along with the Schiff base ligand were screened for their anticancer activities. The CT-DNA binding studies revealed high binding propensity for metal complexes with Kb values 1.50 × 104 M-1 for 1; 3.62 × 104 M-1 for 2; 2.53 × 104 M-1 for 3 and 1.8 × 104 M-1 for 4, respectively. Anticancer studies against A549 & MCF-7 demonstrated excellent antiproliferative activity with IC50 values in the range 17.62-48.82 μM. A standard drug cisplatin was employed to compare the activity of metal complexes. The complexes exhibited remarkable antitumour activity due to their high binding ability with DNA. It is interesting to observe that the complexes did not produce any cytotoxicity towards the normal cell lines.

The Synthesis of Gemini Ionic Salt in the Form of a (Tetra)Fluoborate of 1,4-Bis- ((1-Decyloimidazol-3-Yl)Methyl)Benzene

Ionic liquids as anticorrosion agents have a wide spectrum of unique properties, which make them less harmful than the majority of typical organic corrosion inhibitors in antifreeze. The synthesis of ionic liquids enables them to be provided with the desired physicochemical and thermodynamical properties by the appropriate selection of cations, anions, and alkyl substituents on the cations. The aim of this paper is the synthesis of the gemini ionic salt (ionic liquid) made up of two imidazole rings with a linear alkyl substituent with 10 carbon atoms, bonded by a 1,4-dimethylphenyl moiety. Such compounds are studied in view of steel protection against oxidizing and corrosive effects. The compound was obtained in a satisfactory yield.

One-Pot Synthesis of Quinazoline Derivatives Using Copper Nanocatalyst Stabilized on Graphene Oxide Functionalized by N1,N2-bis((Pyridine-2-yl)Methyl)Benzene-1,2-Diamine

Having a biological property is just one of features of N-heterocycles. Another thing is to be dramatically well-designed. In other words, awe-inspiring combination of materials and the thing that really makes these materials just unique of its kind is nothing but its medical properties. That is why, majority of scientists are full of enthusiasm for synthesizing of these types of materials. ln this article, we have reported five effective methods for synthesizing quinazoline, which is a immensely important group of N-heterocycles with using copper nanocatalyst stabilized on graphene oxide functionalized by N1,N2-bis((pyridine-2-yl)methyl)benzene-1,2-diamine. Moreover, we have investigated the effects of substitutions connected to aldehydes, benzylamines and benzamides as a carbon source of quinazoline heterocyclic ring. Finally, we have assessed effects kinds of ammonium salts as a nitrogen source of quinazoline heterocyclic ring.

Crystal structure of poly[bis[μ 3-1,3,5-tris[(1H-imidazol-1-yl)methyl]benzene-κ 3 N:N′:N″]nickel(II)] hexafluorosilicate, C36H36N12NiSiF6

C36H36N12NiSiF6, trigonal, P 3 ‾ $P‾{3}$ (no. 147), a = 9.5965(3) Å, c = 11.8821(8) Å, V = 947.65(9) Å3, Z = 1, R gt (F) = 0.0437, wR ref (F 2) = 0.1076, T = 223 K.

Covalent Triazine Frameworks Based on the First Pseudo-Octahedral Hexanitrile Monomer via Nitrile Trimerization: Synthesis, Porosity, and CO2 Gas Sorption Properties

Herein, we report the first synthesis of covalent triazine-based frameworks (CTFs) based on a hexanitrile monomer, namely the novel pseudo-octahedral hexanitrile 1,4-bis(tris(4′-cyano-phenyl)methyl)benzene 1 using both ionothermal reaction conditions with ZnCl2 at 400 °C and the milder reaction conditions with the strong Brønsted acid trifluoromethanesulfonic acid (TFMS) at room temperature. Additionally, the hexanitrile was combined with different di-, tri-, and tetranitriles as a second linker based on recent work of mixed-linker CTFs, which showed enhanced carbon dioxide captures. The obtained framework structures were characterized via infrared (IR) spectroscopy, elemental analysis, scanning electron microscopy (SEM), and gas sorption measurements. Nitrogen adsorption measurements were performed at 77 K to determine the Brunauer-Emmett-Teller (BET) surface areas range from 493 m2/g to 1728 m2/g (p/p0 = 0.01–0.05). As expected, the framework CTF-hex6 synthesized from 1 with ZnCl2 possesses the highest surface area for nitrogen adsorption. On the other hand, the mixed framework structure CTF-hex4 formed from the hexanitrile 1 and 1,3,5 tricyanobenzene (4) shows the highest uptake of carbon dioxide and methane of 76.4 cm3/g and 26.6 cm3/g, respectively, at 273 K.

The crystal structure of catena-poly[bis(µ2-1,2-bis((1H-imidazol-1-yl)methyl)benzene- κ2 N:N′)-bis(nitrato-κO)copper(II)], C28H28N10O6Cu

C28H28N10O6Cu, triclinic, P 1 ‾ $P\bar{1}$ (no. 2), a = 8.6869(7) Å, b = 9.0094(6) Å, c = 9.5839(8) Å, α = 74.288(7)°, β = 87.672(9)°, γ = 76.110(7)°, V = 700.69(11) Å3, Z = 1, R gt (F) = 0.0492, wR ref (F 2) = 0.0979, T = 293(2) K.