scholarly journals Congenital Leukemia Report of 2 Cases

2019 ◽  
Vol 32 (5-6) ◽  
pp. 153-62
Author(s):  
S. Untario ◽  
Erwin Sarwono ◽  
E. K. Kariyadi ◽  
Sylviaty M. D. ◽  
Netty R. H. T
Keyword(s):  
Medical Literature ◽  
Down's Syndrome ◽  
Down’S Syndrome ◽  
Congenital Leukemia

Two cases of congenital leukemia are reported, one of which was associated with Down's syndrome. Both cases were lymphoblastic as observed morphologically and by the negative Sudanophilia. To the best knowledge of the authors these cases are the first two cases of congenital leukemia reported in the Indonesian medical literature.

scholarly journals In vitro cell growth in neonates with Down's syndrome and transient myeloproliferative disorder

Blood ◽  
1981 ◽  
Vol 58 (4) ◽  
pp. 675-677
Author(s):  
JF Denegri ◽  
PC Rogers ◽  
KW Chan ◽  
J Sadoway ◽  
JW Thomas
Keyword(s):  
Cell Growth ◽  
Down's Syndrome ◽  
Down’S Syndrome ◽  
Myeloproliferative Disorders ◽  
Maternal Serum ◽  
Blast Cell ◽  
Congenital Leukemia ◽  
Myeloproliferative Syndrome ◽  
Serum Inhibitor

Bone marrow and peripheral blood cells from three newborns with Down's syndrome and transient myeloproliferative disorders were cultured in vitro. In the methylcellulose semiliquid system, normal colony formation with maturation and differentiation into granulocytes and monocyte-macrophages were observed in all three patients. This is different from the growth pattern usually seen in acute nonlymphocytic leukemia. A maternal serum inhibitor of both normal allogeneic GM-CFU and blast cell growth was also demonstrated, but its role in pathogenesis is uncertain. Normal in vitro granulopoiesis may help to differentiate the transient myeloproliferative syndrome from congenital leukemia in newborns with Down's syndrome.

scholarly journals In vitro cell growth in neonates with Down's syndrome and transient myeloproliferative disorder

Blood ◽  
1981 ◽  
Vol 58 (4) ◽  
pp. 675-677 ◽  
Author(s):  
JF Denegri ◽  
PC Rogers ◽  
KW Chan ◽  
J Sadoway ◽  
JW Thomas
Keyword(s):  
Cell Growth ◽  
Down's Syndrome ◽  
Down’S Syndrome ◽  
Myeloproliferative Disorders ◽  
Maternal Serum ◽  
Blast Cell ◽  
Congenital Leukemia ◽  
Myeloproliferative Syndrome ◽  
Serum Inhibitor

Abstract Bone marrow and peripheral blood cells from three newborns with Down's syndrome and transient myeloproliferative disorders were cultured in vitro. In the methylcellulose semiliquid system, normal colony formation with maturation and differentiation into granulocytes and monocyte-macrophages were observed in all three patients. This is different from the growth pattern usually seen in acute nonlymphocytic leukemia. A maternal serum inhibitor of both normal allogeneic GM-CFU and blast cell growth was also demonstrated, but its role in pathogenesis is uncertain. Normal in vitro granulopoiesis may help to differentiate the transient myeloproliferative syndrome from congenital leukemia in newborns with Down's syndrome.

Is Mania Incompatible with Down's Syndrome?

1985 ◽  
Vol 146 (3) ◽  
pp. 319-320 ◽  
Author(s):  
Robert Sovner ◽  
Anne Desnoyers Hurley ◽  
Richard Labrie
Keyword(s):  
Mental Retardation ◽  
Major Depression ◽  
Medical Literature ◽  
Down's Syndrome ◽  
Down’S Syndrome ◽  
Affective Illness

In reviewing the medical literature on the association between affective illness and mental retardation (Sovner & Hurley, 1983), we were intrigued to find that, although there were many cases of major depression and depressive neurosis among people with Down's syndrome, there were no reports of mania in such individuals. This finding provoked us to pursue the hypothesis that Down's syndrome may preclude the development of mania.

scholarly journals Dermatological Manifestations of Down's Syndrome

2001 ◽  
Vol 5 (4) ◽  
pp. 289-293 ◽  
Author(s):  
Benjamin Barankin ◽  
Lyn Guenther
Keyword(s):  
Mental Retardation ◽  
Medical Care ◽  
Medical Literature ◽  
Down's Syndrome ◽  
Down’S Syndrome ◽  
Psychosocial Aspects ◽  
Cutaneous Manifestations ◽  
Congenital Condition ◽  
Immunological Deficiency ◽  
Physical Features

Background: Down's syndrome (DS) is an extensively researched congenital condition characterized by mental retardation and distinct physical features. The cutaneous manifestations of DS are numerous, yet they seldom receive appropriate attention. Objective: To review the dermatological conditions associated with DS. Methods: A review of the medical literature. Results: DS is associated with an increased incidence of numerous dermatological conditions, some of which may be related to an immunological deficiency. Conclusion: Along with the importance of understanding the physical and psychosocial aspects of DS, an appreciation of the dermatological manifestations of this condition is integral to comprehensive medical care.

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