scholarly journals Dermatological Manifestations of Down's Syndrome

2001 ◽  
Vol 5 (4) ◽  
pp. 289-293 ◽  
Author(s):  
Benjamin Barankin ◽  
Lyn Guenther
Keyword(s):  
Mental Retardation ◽  
Medical Care ◽  
Medical Literature ◽  
Down's Syndrome ◽  
Down’S Syndrome ◽  
Psychosocial Aspects ◽  
Cutaneous Manifestations ◽  
Congenital Condition ◽  
Immunological Deficiency ◽  
Physical Features

Background: Down's syndrome (DS) is an extensively researched congenital condition characterized by mental retardation and distinct physical features. The cutaneous manifestations of DS are numerous, yet they seldom receive appropriate attention. Objective: To review the dermatological conditions associated with DS. Methods: A review of the medical literature. Results: DS is associated with an increased incidence of numerous dermatological conditions, some of which may be related to an immunological deficiency. Conclusion: Along with the importance of understanding the physical and psychosocial aspects of DS, an appreciation of the dermatological manifestations of this condition is integral to comprehensive medical care.

scholarly journals Opioids and Down’s syndrome

2006 ◽  
Vol 2 (2) ◽  
pp. 93 ◽  
Author(s):  
Federica Mafrica, MD ◽  
Vincenzo Fodale, MD
Keyword(s):  
Opioid Receptors ◽  
Down's Syndrome ◽  
Down’S Syndrome ◽  
Perioperative Period ◽  
Congenital Condition ◽  
The Central Nervous System ◽  
Specific Receptors ◽  
Multiple Abnormalities ◽  
Physical Features ◽  
Major Metabolic Pathway

Opioids are used in clinical practice for sedation, anesthesia, and analgesia. Their effects depend on their pharmacokinetic and pharmacodynamic characteristics. The liver is the major site for the biotransformation of most opioids. The major metabolic pathway is oxidation. Metabolism influences distribution, clearance, onset, and offset of opioid drugs. Action also depends on the coupling of opioids with the class of receptors involved and on localization of specific receptors. Three major types of opioid receptors, designated as μ, ẟ, and ϰ, present in the central nervous system, are coupled to G proteins and inhibit adenylyl cyclase. Down’s syndrome is a congenital condition characterized by mental retardation and particular physical features. Neurotransmission alterations are important. Alteration in the concentration of opioids in the cortex of these patients has been demonstrated. Neurobiological abnormalities and, in some, abnormalities in the neurotransmission systems, anxiety, and, in particular, nociception all suggest that structural and functional alterations of opioid receptors may be present. A clear knowledge of these multiple abnormalities is essential for skillful management of the perioperative period and for a good outcome for patients with Down’s syndrome.

Is Mania Incompatible with Down's Syndrome?

1985 ◽  
Vol 146 (3) ◽  
pp. 319-320 ◽  
Author(s):  
Robert Sovner ◽  
Anne Desnoyers Hurley ◽  
Richard Labrie
Keyword(s):  
Mental Retardation ◽  
Major Depression ◽  
Medical Literature ◽  
Down's Syndrome ◽  
Down’S Syndrome ◽  
Affective Illness

In reviewing the medical literature on the association between affective illness and mental retardation (Sovner & Hurley, 1983), we were intrigued to find that, although there were many cases of major depression and depressive neurosis among people with Down's syndrome, there were no reports of mania in such individuals. This finding provoked us to pursue the hypothesis that Down's syndrome may preclude the development of mania.

The effects of educator attitudes and expectations on the educational programming for children with Down's Syndrome in the context of integration

1988 ◽  
Vol 2 ◽  
pp. 43-48
Author(s):  
Cam Wright
Keyword(s):  
Mental Retardation ◽  
Chromosomal Abnormalities ◽  
Down's Syndrome ◽  
Down’S Syndrome ◽  
Severe Mental Retardation ◽  
Educational Programming ◽  
Educator Attitudes

Down's Syndrome has long been associated with mental retardation. This has resulted in expectations of moderate or severe mental retardation in individuals with Down's Syndrome (Hopkins, 1983). Although there has been acceptance of the possibility of variability of attainments, a certain predictability of outcome has been assumed since Down's Syndrome is a condition resulting from known chromosomal abnormalities (Springer & Steele, 1980; Hopkins, 1983).

scholarly journals Congenital Leukemia Report of 2 Cases

2019 ◽  
Vol 32 (5-6) ◽  
pp. 153-62
Author(s):  
S. Untario ◽  
Erwin Sarwono ◽  
E. K. Kariyadi ◽  
Sylviaty M. D. ◽  
Netty R. H. T
Keyword(s):  
Medical Literature ◽  
Down's Syndrome ◽  
Down’S Syndrome ◽  
Congenital Leukemia

Two cases of congenital leukemia are reported, one of which was associated with Down's syndrome. Both cases were lymphoblastic as observed morphologically and by the negative Sudanophilia. To the best knowledge of the authors these cases are the first two cases of congenital leukemia reported in the Indonesian medical literature.

Psychiatric Disorders in Mildly and Severely Mentally Retarded Urban Children and Adolescents: Epidemiological Aspects

1986 ◽  
Vol 149 (1) ◽  
pp. 68-74 ◽  
Author(s):  
Christopher Gillberg ◽  
Eva Persson ◽  
Marianne Grufman ◽  
Ulla Themnér
Keyword(s):  
Mental Retardation ◽  
Children And Adolescents ◽  
Psychiatric Disorders ◽  
Down's Syndrome ◽  
Down’S Syndrome ◽  
Mentally Retarded ◽  
Urban Children ◽  
Psychiatric Condition ◽  
Child Population ◽  
Mentally Retarded Children

A total of 149 children aged 13–17 years were examined. 83 were mildly and 66 severely mentally retarded. These children, especially the severely retarded ones, are representative of all mentally retarded children born in 1966–1970 and living in Göteborg, Sweden. 64% of the severely mentally retarded and 57% of the mildly mentally retarded children were suffering from a handicapping psychiatric condition. Autism-like ‘psychotic behaviour’ was common in the severely retarded. 0.2% of the total child population aged 13–17 years suffering from the combination of mental retardation and ‘psychotic behaviour’. Epilepsy was associated with psychiatric abnormality, but Down's syndrome was generally not so associated.

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