scholarly journals ISSLEDOVANIE EFFEKTIVNOSTII BEZOPASNOSTI TERAPII TERIPARATIDOM(FORSTEO) V TEChENIE 1 GODA PRI POSTMENOPAUZAL'NOMOSTEOPOROZE

2006 ◽  
Vol 9 (2) ◽  
pp. 6-12
Author(s):  
L Ya ROZhINSKAYa ◽  
S D ARAPOVA ◽  
L K DZERANOVA ◽  
N N MOLITVOSLOVOVA ◽  
A V IL'IN ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Lumbar Spine ◽  
Adverse Effects ◽  
Bone Metabolism ◽  
Postmenopausal Women ◽  
Proximal Femur ◽  
Fragility Fractures ◽  
Bone Alkaline Phosphatase ◽  
Mineral Density

The aims of the reported multinational open study were to estimate the influence of subcutaneous injections of 20 mkg daily Teriparatide on bone mineral density (BMD) at the lumbar spine and proximal femur, the markers of bone metabolism, the quality of life as well as the safety of treatment. Duration of the treatment period was one year. Fifty postmenopausal women with osteoporosis (L1-L4 T-score mean -3,2±0,6 SD) were enrolled in the study. 70,8% of patients had fragility fractures. Forty four patients (78%) remained until the end of the study. BMD was detected by dual energy X-ray absorptiometry (DXA) («Prodigy», Lunar and «Hologic» 4500 W) at the lumbar spine (L1-L4) and proximal femur with converting to the standardized BMD. Bone alkaline phosphatase (BAP) and osteocalcin (OC) were measured as markers of bone formation and C-terminal cross-linking telopeptide (CTX) were measured in serum as a marker of bone resorption. The significant increase in BMD was found at the lumbar spine (L1-L412,5±6,6%), whereas BMD at the proximal femur did not change significantly. The levels of markers of bone metabolism were increased after 3 months of the treatment and to the end of the study were 192,2%; 385%; 526,3% higher versus the baseline levels for BAP, OC., CTX consequently. There was also found a significant improvement in the quality of life of the patients which was estimated by EQ-5D inquirer at the baseline visit and at the end of the study. The adverse effects, which were related to the teriparatide injections, were observed in 44% of the patients. Due to the adverse effects Tereiparatide was cancelled for 6 (12%) patients. In other cases the adverse effects were slight and the cancellation of treatment was not required. Conclusions: The daily injections of Teriparatide (20 mkg) during 1 year provide the significant increase in BMD at the lumbar spine for postmenopausal women with osteoporosis as well as the early increase in the bone turnover rate. Treatment with Teriparatide improves the quality of life for women with postmenopausal osteoporosis. The daily injections of Teriparatide during 1 year are well tolerated and safe.

scholarly journals Quality of Life in Postmenopausal Women and Its Correlation with Bone Mineral Density

2015 ◽  
Vol 26 (3) ◽  
pp. 58-64
Author(s):  
C Zonunsanga ◽  
Hmingthanmawii LNU ◽  
Minggam Pertin ◽  
Chongreilen Chiru ◽  
Romi Singh Nongmaithem ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Bone Mineral Density ◽  
Lumbar Spine ◽  
Femoral Neck ◽  
Postmenopausal Women ◽  
Bone Mineral ◽  
Mineral Density ◽  
Significant Positive Association ◽  
The Mean

Abstract Aim To evaluate the quality of life in postmenopausal women and its correlation with bone mineral density. Study design Cross-sectional study. Duration of the study October 2012 to September 2014. Settings Physical Medicine and Rehabilitation Department, Regional Institute of Medical Sciences, Imphal. Study population Postmenopausal women who attended the department during the study period. Materials and Methods Quality of life was assessed using WHOQOL-BREF questionnaire, a validated brief version of the WHOQOL-100. Bone mineral density (BMD) in the lumbar spine, femoral neck and trochanter were measured using dual energy x-ray absorptiometry (DEXA) scan – GE Lunar model. Results A total of 125 patients were studied. The mean t-scores in lumbar spine, femoral neck and trochanter were -2.550 ± 1.209, -1.831 ± 0.921 and -1.621 ± 1.064 respectively. The mean BMD (g/cm2) in lumbar spine, femoral neck and trochanter were 0.867 ± 0.144, 0.789 ± 0.131 and 0.682 ± 0.139 respectively. The mean overall WHOQOL score was 57.68±10.07. There were statistically significant positive association of WHOQOL score with the BMDs in lumbar spine, femoral neck and trochanter (p < 0.05). Multivariate regression showed significant relation of overall WHOQOL score with BMD lumbar spine (b=0.229; R2=0.119), BMD femoral neck (b=0.285; R2=0.129), and BMD trochanter (b=0.245; R2=0.119). Conclusion BMDs in the lumbar spine, femoral neck and trochanter had a positive correlation with quality of life scores. BMD also had a good predictive value in determining the quality of life in postmenopausal women.

scholarly journals ADDITIONAL BENEFITS OF ANTIHYPERTENSIVE MOXONIDINE THERAPY IN POSTMENOPAUSAL WOMEN WITH ARTERIAL HYPERTENSION

2014 ◽  
Vol 13 (1) ◽  
pp. 8-15 ◽  
Author(s):  
E. N. Dudinskaya ◽  
O. N. Tkacheva
Keyword(s):  
Lumbar Spine ◽  
Bone Resorption ◽  
Arterial Hypertension ◽  
Bone Metabolism ◽  
Postmenopausal Women ◽  
Proximal Femur ◽  
Target Range ◽  
Bone Resorption Marker ◽  
Mineral Density ◽  
Converting Enzyme Inhibitors

Aim. To assess the effects of moxonidine in terms of target blood pressure (BP) achievement; to identify potential additional benefits of moxonidine and its effects on bone metabolism and bone mineral density (BMD) in postmenopausal women with arterial hypertension (AH).Material and methods. The study included 48 postmenopausal women with Stage 1-2 AH, aged 57-71 years.Results. All participants were divided into two groups by the type of antihypertensive therapy: those receiving moxonidine and those receiving angiotensin-converting enzyme inhibitors / angiotensin receptor antagonists (ACEI/ARA). All women also received calcium and vitamin D. All participants had AH and osteopenia (both in the lumbar spine and proximal femur, according to the X-ray absorptiometry results). In the moxonidine group, BP levels remained within the target range 48 weeks later. There was a significant reduction in the levels of a bone resorption marker (p=0,041), while the dynamics of an osteopoetic marker was statistically non-significant (p=0,31). A tendency towards increasing BMD in lumbar spine and proximal femur was also observed (p=0,059 and p=0,068, respectively). In the ACEI/ARA group, BP levels also remained within the target range 48 weeks later. However, no significant changes in the levels of bone metabolism markers were registered. There was a tendency towards decreasing BMD in lumbar spine and proximal femur (p=0,052 and p=0,054, respectively).Conclusion. Moxonidine therapy was associated with a significant reduction in bone resorption activity, as demonstrated by the decrease in the concentration of a bone resorption marker, as well as with a tendency towards increasing BMD.

Metabolic and musculoskeletal effects of cystic fibrosis

2015 ◽  
Author(s):  
Uta Hill ◽  
Jane Ashbrook ◽  
Charles Haworth
Keyword(s):  
Quality Of Life ◽  
Bone Mineral Density ◽  
Urinary Incontinence ◽  
Bone Mineral ◽  
Negative Impact ◽  
Fragility Fractures ◽  
Pulmonary Complications ◽  
Mineral Density ◽  
Airway Clearance

This chapter provides a comprehensive update on the prevention, recognition, and treatment of low bone mineral density in people with CF. As life expectancy improves, the extra-pulmonary complications of CF are becoming increasingly important to quality of life. Up to 25 per cent of CF patients have reduced bone mineral density in adulthood, leading to the development of fragility fractures which cause pain, thereby interfering with airway clearance and predisposing to pulmonary infection. Osteoporosis can be a relative contraindication for lung transplantation. Other important musculoskeletal issues including CF arthropathy, growth, and urinary incontinence are covered. CF arthropathy is a non-erosive episodic sero-negative arthritis, often difficult to treat and which may require specialist input. Urinary incontinence is common girls and women with CF and has a negative impact on quality of life and ability to complete therapies. The pathophysiology and management of urinary incontinence are discussed.

scholarly journals Health-related quality of life in Romanian postmenopausal women with osteoporosis and fragility fractures

2018 ◽  
Vol Volume 13 ◽  
pp. 2465-2472 ◽  
Author(s):  
Alina Deniza Ciubean ◽  
Rodica Ana Ungur ◽  
Laszlo Irsay ◽  
Viorela Mihaela Ciortea ◽  
Ileana Monica Borda ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Postmenopausal Women ◽  
Fragility Fractures ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related

The influence of alendronate therapy on the quality of life in postmenopausal women with reduced bone mineral density

2018 ◽  
Vol 86 (4) ◽  
pp. 292
Author(s):  
Grażyna Bączyk ◽  
Dorota Formanowicz ◽  
Paweł Kleka ◽  
Włodzimierz Samborski
Keyword(s):  
Quality Of Life ◽  
Postmenopausal Women ◽  
Life Assessment ◽  
Mineral Density ◽  
Mean Values ◽  
Effect Of Treatment ◽  
The Mean ◽  
General Scale ◽  
Specific Scale

Introduction and objective: The aim of the study was to evaluate the effect of treatment on the quality of life (QoL) in postmenopausal women characterized by the reduced BMD.Material and methods: Postmenopausal women (n=102), mean age (65.09±5.6 years) were included in this study. The participants were divided into two groups, depending on the treatment or lack of treatment. For assessment of their QoL, QUALEFFO-41 scale and WHOQOL-100 scale were used.Results: Mean values of the QUALEFFO-41 scale of women who used alendronate were significantly lower than those found in subjects not treated with this drug in the following areas: pain (p=0.03), ADL (p=0.03), jobs around the house (p=0.01), mobility (p=0.01), health perception (p=0.03), emotional function (p= 0.007) and total QoL  (p=0.005). The mean values of the WHOQOL-100 scale almost did not differ significantly between both groups of studied patients. An exception was the level of independence, with mean values of women not receiving bisphosphonates being significantly higher than those of patients using bisphosphonates therapy (p=0.04).Conclusions. Quality of life assessment of women with osteoporosis and osteopenia using a specific scale and general scale can be a valuable clue in the planning of treatment, nursing care and psychological care.

scholarly journals Social and mental functioning in postmenopausal women with low bone mineral density

2018 ◽  
Vol 71 (5-6) ◽  
pp. 171-179
Author(s):  
Jelena Zvekic-Svorcan ◽  
Martina Miklos ◽  
Karmela Filipovic ◽  
Milan Cvetkovic ◽  
Miljanka Vuksanovic ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Bone Mineral Density ◽  
Femoral Neck ◽  
Postmenopausal Women ◽  
Bone Mineral ◽  
Mental Functioning ◽  
Mineral Density ◽  
T Score ◽  
History Of

Introduction. Osteoporosis is a systemic, metabolic, progressive bone disease characterized by reduced bone mineral density leading to bone fragility and reduced quality of life. The objective of this study was to examine the quality of social and mental functioning in postmenopausal women with reduced mineral bone density. Material and Methods. This prospective cross-sectional study included 210 postmenopausal women aged ? 50 years, who were referred for osteodensitometry to the Special Hospital for Rheumatic Diseases Novi Sad, Serbia. The study was conducted in the period from February 24 to April 3, 2017. All women completed the Serbian version of the Quality of Life Questionnaire of the European Foundation for Osteoporosis (41). They all underwent bone mineral density measurement in two regions of interest, and the results were interpreted according to the current definition of osteoporosis. The participants? social and mental functioning was analyzed including the following variables: age, place of residence, educational attainment, employment, nutritional status, bone mineral density, and low-trauma fractures. Statistical processing and analyses were performed using Statistical Package for the Social Sciences, version 20. Results. A statistically significant negative correlation was noted between social functioning and the T-score for the femoral neck (r = -0.438), hip (r = -0.412) and spine (r = -0.226), as well as mental functioning with the T-score for the femoral neck (r = -0.424), hip (r = -0.454) and spine (r = -0.319). Patients with a history of fractures had a poorer quality of social functioning (t = 2.17, p < 0.05). Conclusion. The examinees of older age, with poor socio-demographic status, reduced bone mineral density, history of low-trauma fractures presented with lower quality of social and mental functioning.

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