scholarly journals Diabetic neuroosteoarthropathy: the modern approaches for diagnosis and immobilization period determination (review)

2015 ◽  
Vol 9 (2) ◽  
pp. 15 ◽  
Author(s):  
Y A Kaminarskaya
Keyword(s):  
Diabetic Neuroosteoarthropathy

scholarly journals Immunohistochemical features of the bone tissue of the lower extremities in patients with type 2 diabetes mellitus

2022 ◽  
Vol 24 (5) ◽  
pp. 448-455
Author(s):  
A. Yu. Tokmakova ◽  
E. A. Kogan ◽  
E. L. Zaitseva ◽  
S. A. Demura ◽  
N. V. Zharkov ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Bone Resorption ◽  
Bone Tissue ◽  
Immunohistochemical Study ◽  
Control Group ◽  
Diabetic Neuroosteoarthropathy ◽  
Group 1

Background: Diabetic neuroosteoarthropathy is a serious disabling complication of diabetes mellitus, which, in the absence of timely correct treatment, can lead to high amputations of the affected limb. At present, the reasons and mechanism of the development of Charcot’s foot are not completely clear. It is extremely important to determine the pathophysiological mechanisms of DNOAP formation and to search for reliable markers-predictors of this pathology.Aim: To study the immunohistochemical characteristics of the bone tissue of the lower extremities in patients with diabetic neuroosteoarthropathy in comparison with patients with diabetes mellitus without this pathology.Materials and methods: During the foot surgery, a bone fragment of the foot was harvested for immunohistochemical study of receptor markers for PINP, PIIINP, and RAGE in the group of patients with DNOAP compared with the control group.Results: The study included 20 patients with type 2 diabetes mellitus and were divided into 2 groups: 10 patients with DNOAP made up group 1, 10 patients without DNOAP — group 2.Patients in both groups were comparable in AGE, experience with type 2 diabetes, and glycemic control.During the immunohistochemical study, a significant increase in the staining intensity of receptor markers for PINP, PIIINP, and AGE was recorded in the group of patients with DNOAP compared with the control group (p <0.05).Conclusion: For the first time, an immunohistochemical study of markers of bone resorption and AGE was carried out in persons with DNOAP. The results obtained indicate impaired collagen formation and, as a consequence, impaired bone formation and bone resorption in patients with DNOAP: in group 1, a statistically significant increase in the expression of PINP, PIIINP, and RAGE was revealed.

scholarly journals The combination of common neuroosteoarthropathy and diabetic dermatopathy in type 2 diabetes mellitus

2020 ◽  
Vol 23 (2) ◽  
pp. 201-208
Author(s):  
Alla Yu. Tokmakova ◽  
Ekaterina S. Gracheva ◽  
Ekaterina L. Zaitseva ◽  
Alexandr V. Vorontsov
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Diabetic Neuropathy ◽  
Adequate Treatment ◽  
Atypical Diabetes ◽  
Long Course ◽  
Diabetic Neuroosteoarthropathy

Diabetic neuroosteoarthropathy (Charcots osteoarthropathy, DNAP, Charcots foot) is a common complication of diabetic neuropathy, which can be easily diagnosed in clinical practice and usually is corrected without leading to severe deformation of the affected joint in case of timely and adequate treatment. We present the result of long-term clinical observation of a patient with early development of complications of type 2 diabetes mellitus, diabetic dermatopathy, common DNOAP with damage to the joints of the feet, ankles, knees and elbows. A feature of the described clinical case is the prevalence of osteoarticular disorders with seizure of atypical diabetes zones knee and elbow joints, the defeat of which is more characteristic of other diseases (such as collagenoses and syphilis), as well as a combination of DNOAP with diabetic dermatopathy. It seems that the causes of such a common arthropathic process lie in the long course of diabetic neuropathy, which debuted long before the diagnosis of type 2 diabetes, as well as the development and progression of this patient in the last decade of observing diabetic nephropathy and associated secondary hyperparathyroidism. In the modern literature, descriptions of combinations of dermatopathies with other complications of diabetes mellitus are extremely rare, and references to a combination of common DNAP and diabetic bullosis have not been found.

Surgical treatment of diabetic neuroosteoarthropathy (DNOAP) and its long-term results

2017 ◽  
pp. 41
Author(s):  
V. M. Bensman ◽  
Yu. P. Savchenko ◽  
S. E. Gumenyuk ◽  
K. G. Triandafilov ◽  
P. P. Vasil’chenko ◽  
...  
Keyword(s):  
Surgical Treatment ◽  
Long Term Results ◽  
Diabetic Neuroosteoarthropathy

scholarly journals Indications for various options of foot deformities orthopedic correction in diabetic neuroosteoarthropathy

2020 ◽  
Vol 23 (4) ◽  
pp. 374-385
Author(s):  
Petr S. Bardiugov ◽  
Mikhail V. Parshikov ◽  
Gagik R. Galstyan ◽  
Nikolaj V. Yarygin
Keyword(s):  
Diabetes Mellitus ◽  
Surgical Treatment ◽  
Clinical Course ◽  
Pathological Process ◽  
Foot Deformities ◽  
Orthopedic Treatment ◽  
Surgical Interventions ◽  
Prevention Of Relapse ◽  
Diabetic Neuroosteoarthropathy ◽  
Single Approach

Diabetic osteoarthropathy is one of the most difficult complication of diabetes mellitus, requiring the cooperation of a many of specialitys, including traumatologists - orthopedists. However, there is no single approach to the choice of orthopedic treatment tactics for this group of patients. From 2015 to 2018 inclusive, there were 35 patients with diabetic osteoarthropathy that received conservative or surgical orthopedic treatment. 11 patients received conservative orthopedic treatment; 24 patients received surgical treatment. A total of 26 surgical interventions were performed. Two types of surgical interventions were performed: 1) resection of the protruding fragment of one or another bone of the tarsus - 12 operations 2) reconstructive surgery aimed at correcting gross deformation of the middle and / or hindfoot - 14 operations. Along with general clinical examination, all patients underwent orthopedic examination, determining the degree of blood supply disturbance. A differentiated approach to choosing the method of orthopedic treatment of the presented group of patients allowed to restore limb supportability, ensure stability in the ankle joint and joints of the middle foot, create conditions for healing and prevention of relapse of the ulcer. The experience gained allowed us to offer indications for a particular method of orthopedic treatment of foot deformities in diabetic osteoarthropathy, depending on the stage of the pathological process, its location, the severity of the deformation, and the clinical course of this pathology.

Sign in / Sign up

Export Citation Format

Share Document