Efficacy and Safety of Miniscalpel Acupuncture, Non-Steroidal Anti-Inflammatory Drugs or Combined Treatment for Chronic Neck Pain: An Assessor-Blinded Randomized Controlled Pilot Study

Abstract Introduction: To compare the efficacy and safety of non-steroidal anti-inflammatory drugs (NSAID), corticosteroid (CS), and a combination of both drugs to prevent cystoid macular edema (CME) after cataract surgery. Methods We searched Pubmed, Cochrane Library, and Embase electronic databases to assess the relevant randomized controlled trials (RCTs) up to 28 April 2021. Network meta-analysis was registered on PROSPERO (CRD42020182520). Results Twenty-four RCTs were included in this review. The NSAID and combination of both drugs were significantly reduced the risk of developing CME than CS alone in non-diabetics and mix population. In the ranking profiles, the combination therapy showed a significant advantage over the single drugs and was less likely to develop CME. Diclofenac was the most likely to reduce the odds of developing CME compared with bromfenac and nepafenac. Dexamethasone was the most likely to reduce the odds of developing CME compared with betamethasone and fluorometholone. Conclusion NSAID combination with CS has significantly reduced the risk of developing CME postoperatively than the single drug. Diclofenac was superior to bromfenac and nepafenac in preventing CME. Dexamethasone was superior to betamethasone and fluorometholone in preventing CME.

Download Full-text

THU0709 Does the use of analgesic current therapies increase the effectiveness of neck stabilization exercises for improving pain, disability, mood, and quality of life in chronic neck pain? a randomized, controlled, single-blind study (a pilot study)

10.1136/annrheumdis-2017-eular.5843 ◽

2017 ◽

Author(s):

H Yesil ◽

S Hepguler ◽

U Dundar ◽

S Taravati ◽

B Isleten

Keyword(s):

Quality Of Life ◽

Pilot Study ◽

Neck Pain ◽

Chronic Neck Pain ◽

Randomized Controlled ◽

Pain Disability ◽

Current Therapies ◽

Neck Stabilization ◽

Single Blind

Download Full-text

Acupuncture with Non-Steroidal Anti-Inflammatory Drugs (Nsaids) versus Acupuncture Or Nsaids Alone for the Treatment of Chronic Neck Pain: An Assessor-Blinded Randomised Controlled Pilot Study

Acupuncture in Medicine ◽

10.1136/acupmed-2013-010410 ◽

2014 ◽

Vol 32 (1) ◽

pp. 17-23 ◽

Cited By ~ 12

Author(s):

Jae-Heung Cho ◽

Dong-Hyun Nam ◽

Ki-Tack Kim ◽

Jun-Hwan Lee

Keyword(s):

Pilot Study ◽

Treatment Group ◽

Neck Pain ◽

Sample Size ◽

Acupuncture Treatment ◽

Chronic Neck Pain ◽

Full Scale ◽

Nsaid Treatment ◽

Inflammatory Drugs ◽

Randomised Controlled

Objective To investigate the feasibility and sample size required for a full-scale randomised controlled trial of the effectiveness of acupuncture with non-steroidal anti-inflammatory drugs (NSAIDs) for chronic neck pain compared with acupuncture or NSAID treatment alone. Methods A total of 45 patients with chronic neck pain participated in the study. For 3 weeks the acupuncture with NSAIDs treatment group took NSAIDs (zaltoprofen, 80 mg) daily while receiving acupuncture treatment three times a week. The acupuncture treatment group received treatment three times a week and the NSAID treatment group took NSAIDs daily. The primary outcomes were to determine the feasibility and to calculate the sample size. As secondary outcomes, pain intensity and pain-related symptoms for chronic neck pain were measured. Results With regard to enrolment and dropout rates, 88.2% of patients consented to be recruited to the trial and 15.6% of participants were lost to follow-up. The sample size for a full-scale trial was estimated to be 120 patients. Although preliminary, there was a significant change in the visual analogue scale (VAS) for neck pain intensity between the baseline measurement and each point of assessment in all groups. However, there was no difference in VAS scores between the three groups. Conclusions This pilot study has provided the feasibility and sample size for a full-scale trial of acupuncture with NSAIDs for chronic neck pain compared with acupuncture or NSAID treatment alone. Further research is needed to validate the effects of acupuncture with NSAIDs. Clinical Trial Registration NIH ClinicalTrials.gov NCT01205958.

Download Full-text