scholarly journals Management tactics in patients with chronic cerebral ischemia during COVID-19 pandemic

2021 ◽  
Vol 13 (3) ◽  
pp. 4-11
Author(s):  
A. A. Kulesh
Keyword(s):  
Cerebral Ischemia ◽  
Essential Element ◽  
White Matter Lesions ◽  
Cardiovascular Prevention ◽  
Pleiotropic Effect ◽  
Cerebrovascular Reactivity ◽  
Chronic Cerebral Ischemia ◽  
Morphological Process ◽  
Current State ◽  
Cerebral Microangiopathy

The article describes the current state of evidence of hypertension and diabetes mellitus roles in the pathophysiology of chronic cerebral ischemia (CCI). CCI is mediated by cerebral microangiopathy, which develops due to vascular remodeling, increased arterial stiffness, endothelial dysfunction, impaired cerebrovascular reactivity, and neuroinflammation. All those mechanisms lead to white matter lesions and cognitive impairment. Arteriolosclerosis is the primary morphological process that damages perforating arteries and arterioles. COVID-19 pandemic can modify CCI progression due to similar pathophysiology. In particular, COVID-19-associated coagulopathy can lead to silent lacunar infarctions and lacunar stroke development. Treatment features of patients with CCI during the COVID-19 pandemic are reviewed. It is concluded that special attention in this group of patients should be paid to primary and secondary cardiovascular prevention issues, an essential element of which is the use of dipyridamole since it has a pleiotropic effect.

Detection of impaired cerebrovascular reactivity in patients with chronic cerebral ischemia using whole-brain 7T MRA

2020 ◽  
Vol 29 (9) ◽  
pp. 105081
Author(s):  
Ikuko Uwano ◽  
Hiroyuki Kameda ◽  
Taisuke Harada ◽  
Masakazu Kobayashi ◽  
Wataru Yanagihara ◽  
...  
Keyword(s):  
Cerebral Ischemia ◽  
Cerebrovascular Reactivity ◽  
Chronic Cerebral Ischemia ◽  
Whole Brain

scholarly journals Features of epilepsy in acute and chronic cerebral ischemia

2017 ◽  
Vol 98 (6) ◽  
pp. 877-883
Author(s):  
T V Danilova
Keyword(s):  
Ischemic Stroke ◽  
Cerebral Ischemia ◽  
Right Hemisphere ◽  
Epileptic Seizures ◽  
Risk Groups ◽  
Cerebrovascular Reactivity ◽  
Circulation System ◽  
Chronic Cerebral Ischemia ◽  
Ischemic Lesion ◽  
The Brain

Aim. To study clinical features, functional and neuroimaging characteristics of the brain of patients with ischemic brain disease and epileptic seizures. Methods. 772 patients with acute and chronic cerebral ischemia (265 stroke patients with epileptic seizures and 174 patients with seizures on the background of chronic cerebral ischemia, and 203 patients with stroke and 130 patients with chronic cerebral ischemia without seizures) were comprehensively examined. The clinical neurological examination, electroencephalography, magnetic resonance imaging, ultrasound duplex scanning of extra- and intracranial arteries with the assessment of the level and degree of stenosis and cerebrovascular reactivity were carried out. Results. Focal seizures prevailed in patients with cerebral ischemia. In patients with epileptic seizures on the background of both ischemic stroke and chronic cerebral ischemia cortical localization of ischemic foci prevailed. Early epileptic seizures in patients with ischemic stroke developed with significantly more frequent localization of ischemic focus in the right hemisphere with the orientation vector of neuroimaging formation of the ischemic lesion in the caudal direction. In patients with chronic cerebral ischemia with epileptic seizures, along with frequent lesion of the cortex, more frequent damage of white matter of the brain was observed. In patients with acute and chronic ischemia of the brain with epileptic seizures, a higher incidence of stenosis of major arteries and predominance of impaired cerebrovascular reactivity in posterior cerebral circulation system were established. Conclusion. Multimodal examination of patients with acute and chronic cerebral ischemia allowed forming risk groups for epileptic seizures.

Vergleich von MRT- und SPECT-Befunden bei Patienten mit zerebraler Mikroangiopathie

1991 ◽  
Vol 30 (05) ◽  
pp. 161-169 ◽  
Author(s):  
C. Weiller ◽  
R. Weigmann ◽  
H.-J. Kaiser ◽  
U. Büll ◽  
R. Schneider ◽  
...  
Keyword(s):  
White Matter Lesions ◽  
Central Nervous System Disease ◽  
Deep White Matter ◽  
Cranial Ct ◽  
System Disease ◽  
Ct Findings ◽  
Hmpao Spect ◽  
Significant Difference ◽  
Cerebral Microangiopathy ◽  
99Mtc Hmpao

Lacunar infarctions and periventricular hypodensity are assumed to be typical CT patterns of cerebral microangiopathy (MA). In 17 patients with such findings and in 6 controls without any signs of central nervous system disease cranial CT, MRT and 99mTc-HMPAO-SPECT were employed. In 7 patients with CT findings of minor MA demonstrated in comparison to controls no significant difference. In 10 cases with CT findings of pronounced MA periventricular rCBF was significantly reduced compared to controls. rCBF of temporal and parietal cortex were not diminished compared to controls. In 14 patients studied with MRT deep white matter lesions were found which appeared solitary, multiple or confluent. Employing 99mTc-HMPAO-SPECT, cerebral MA revealed rCBF reduction in periventricular brain tissue by cerebellar standardization.

Citimax-Darnitsa in the treatment of patients with chronic cerebral ischemia

2017 ◽  
Vol 0 (1.87) ◽  
pp. 117-122
Author(s):  
O.L. Tovazhnianska ◽  
I.O. Lapshina ◽  
A.H. Chernenko ◽  
O.I. Kauk
Keyword(s):  
Cerebral Ischemia ◽  
Chronic Cerebral Ischemia

Clinical and neuroimaging features of chronic cerebral ischemia in polycythemia vera

2021 ◽  
pp. 58-62
Author(s):  
G. V. Zyrina ◽  
T. A. Slyusa
Keyword(s):  
Cerebral Ischemia ◽  
Polycythemia Vera ◽  
Mini Mental State Examination ◽  
Comparison Group ◽  
Cognitive Disorders ◽  
Chronic Cerebral Ischemia ◽  
State Examination ◽  
The Brain

The purpose of the study. To study clinical and neuroimaging features of chronic cerebral ischemia (CCI) in polycythemia vera (PV).Materials and methods. 66 patients with PV were examined – the main group (43 men, 23 women; mean age 62.0 ± 3.4 years), of which 64 (97.0%) patients were diagnosed with CCI. The comparison group consisted of 85 patients with CCI (34 men, 51 women; mean age 67.7 ± 4.6 years), who developed against the background of cerebral vascular atherosclerosis and arterial hypertension. To identify cognitive disorders, we used Mini Mental State Examination (MMSE). Insomnia was studied in accordance with the criteria of the International Classification of Sleep ICDS‑22005. The quality of sleep was determined using a questionnaire from the Federal Somnological Center. Neuroimaging (MRI of the brain) was performed on Siemens Symphony 1.5 T and GE Signa 1.5 T tomographs.Results. Subjective symptoms CCI are characterized by a greater representation of asthenic and insomniac disorders. Transient ischemic attacks in patients with PV are significantly more common than in the comparison group, their frequency depends on the duration of PV. The revealed changes in MRI of the brain in the majority of PV patients with CCI are characteristic of multiinfarction vascular encephalopathy; in the comparison group, changes that characteristic for subcortical arteriosclerotic encephalopathy were more often recorded.

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