The aim of the study. To study changes in the substance of the brain according to magnetic resonance imaging (MRI) and their correlation with the neuropsychological profile in men and women of senile age with chronic cerebral ischemia.Materials and methods. We examined 57 patients with chronic cerebral ischemia of stages 2 and 3, aged from 75 to 93 years. The patients were divided into two groups: group one of men (n = 25), group two of women (n = 32). MRI performed on a GE Medical Systems tomography with 1.5 Tl strength. Investigated the quantitative indicators of MR tomograms in the Ax T2 Flair Propeller mode. Neuropsychological profile was assessed from Mini Mental State Examination, frontal assessment battery– from FAB, clock-drawing test.Results. Comparison of neuroimaging data with cognitive tests reveals the relationship between the severity of cerebral atrophy, leukoaraiosis and cognitive dysfunction. This data must be taken into account when planning treatment and rehabilitation tactics.