scholarly journals High metabolic substrate load induces mitochondrial dysfunction in rat skeletal muscle microvascular endothelial cells

2021 ◽  
Vol 9 (14) ◽  
Author(s):  
Camilla Hansen ◽  
Karina Olsen ◽  
Henriette Pilegaard ◽  
Jens Bangsbo ◽  
Lasse Gliemann ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Endothelial Cells ◽  
Mitochondrial Dysfunction ◽  
Microvascular Endothelial Cells ◽  
Rat Skeletal Muscle ◽  
Metabolic Substrate ◽  
Microvascular Endothelial

Ascorbate Uptake by Microvascular Endothelial Cells of Rat Skeletal Muscle

1996 ◽  
Vol 3 (2) ◽  
pp. 211-221 ◽  
Author(s):  
J. X. Wilson ◽  
S. J. Dixon ◽  
J. Yu ◽  
S. Nees ◽  
K. Tyml
Keyword(s):  
Skeletal Muscle ◽  
Endothelial Cells ◽  
Microvascular Endothelial Cells ◽  
Rat Skeletal Muscle ◽  
Microvascular Endothelial ◽  
Ascorbate Uptake

scholarly journals 2-Chlorohexadecanoic acid induces ER stress and mitochondrial dysfunction in brain microvascular endothelial cells

Redox Biology ◽  
2018 ◽  
Vol 15 ◽  
pp. 441-451 ◽  
Author(s):  
Eva Bernhart ◽  
Nora Kogelnik ◽  
Jürgen Prasch ◽  
Benjamin Gottschalk ◽  
Madeleine Goeritzer ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Er Stress ◽  
Mitochondrial Dysfunction ◽  
Microvascular Endothelial Cells ◽  
Brain Microvascular Endothelial Cells ◽  
Microvascular Endothelial

scholarly journals GLP-1 and Ghrelin Attenuate High Glucose/High Lipid-Induced Apoptosis and Senescence of Human Microvascular Endothelial Cells

2017 ◽  
Vol 44 (5) ◽  
pp. 1842-1855 ◽  
Author(s):  
Pengzhi Liao ◽  
Dan Yang ◽  
Duan Liu ◽  
Yuehong Zheng
Keyword(s):  
Endothelial Cells ◽  
Mitochondrial Dysfunction ◽  
High Glucose ◽  
Metabolic Regulation ◽  
Akt Signaling ◽  
Parp Cleavage ◽  
Microvascular Endothelial Cells ◽  
Endothelial Apoptosis ◽  
High Lipid ◽  
Microvascular Endothelial

Background/Aims: GLP-1 and ghrelin are common appetite-regulating hormones. Both have multiple functions beyond metabolic regulation. However, the effects of GLP-1 and ghrelin on endothelial biology are not fully understood. Here, we investigate the roles of GLP-1 and ghrelin in microvascular endothelial apoptosis and senescence. Methods: Human microvascular endothelial cells (HMECs) were exposed to high glucose/high lipid (HG/HL) conditions and treated with GLP-1 or ghrelin. Cellular apoptosis, senescence, and mitochondrial function were measured. In addition, the MAPK and Akt signaling pathways were examined. Results: Both GLP-1 and ghrelin treatment decreased the number of TUNEL-positive cells and inhibited caspase-3 and PARP cleavage and mitochondrial dysfunction in HG/HL-exposed HMECs. GLP-1, but not ghrelin decreased the number of β-galactosidase (β-gal)-positive cells. Furthermore, GLP-1 and ghrelin inhibited ERK1/2, JNK1/2, and p38 signaling. GLP-1 suppressed Akt signaling, but ghrelin had no effect. Moreover, JNK1/2 and p38 inhibitors, but not ERK1/2 and Akt inhibitors, decreased the number of TUNEL-positive cells. Additionally, only the Akt inhibitor decreased the number of β-gal-positive cells. Conclusion: These results demonstrate that GLP-1 and ghrelin inhibit mitochondrial dysfunction under HG/HL conditions, and suppress endothelial apoptosis via inhibiting JNK1/2 and p38 signaling; moreover, GLP-1 alleviates endothelial senescence via inactivating Akt signaling.

scholarly journals Lipopolysaccharide induces mitochondrial dysfunction in rat cardiac microvascular endothelial cells

Critical Care ◽  
2011 ◽  
Vol 15 (S1) ◽  
Author(s):  
M Vuda ◽  
M Chiusa ◽  
SM Jakob ◽  
J Takala ◽  
C Zuppinger ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Mitochondrial Dysfunction ◽  
Microvascular Endothelial Cells ◽  
Microvascular Endothelial ◽  
Cardiac Microvascular Endothelial Cells

scholarly journals Hyperglycemia‐induced mitochondrial dysfunction and oxidant generation in mouse renal microvascular endothelial cells is reversed by C‐peptide

2009 ◽  
Vol 23 (S1) ◽  
Author(s):  
Himani L. Vejandla ◽  
Jefferson C. Frisbee ◽  
Erinne R. Dabkowski ◽  
John M. Hollander ◽  
Anand Kothur ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Mitochondrial Dysfunction ◽  
Microvascular Endothelial Cells ◽  
C Peptide ◽  
Microvascular Endothelial

scholarly journals Simple, Reliable Isolation, Purification and Cultivation of Murine Skeletal Muscle Microvascular Endothelial Cells

2020 ◽  
Vol 13 (12) ◽  
pp. 290-299
Author(s):  
Jianjie Wang ◽  
Joseph Harvey ◽  
Richard Garrad ◽  
Virginia Huxley ◽  
Laurie Erb ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Endothelial Cells ◽  
Microvascular Endothelial Cells ◽  
Microvascular Endothelial ◽  
Murine Skeletal Muscle ◽  
Reliable Isolation

Isolation of Primary Murine Skeletal Muscle Microvascular Endothelial Cells

10.3791/58901 ◽  
2019 ◽  
Author(s):  
Thomas Müntefering ◽  
Alexander P.E. Michels ◽  
Steffen Pfeuffer ◽  
Sven G. Meuth ◽  
Tobias Ruck
Keyword(s):  
Skeletal Muscle ◽  
Endothelial Cells ◽  
Microvascular Endothelial Cells ◽  
Microvascular Endothelial ◽  
Murine Skeletal Muscle
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