Background: Human resource for health is an essential part of the health system and the key factor to ensure the effectiveness and quality of medical services. Health care needs of people have increased recently leading to the increasing demands of health human resource both in quantity and quality. The prediction of health human needs is very important thus we conducted this study to estimate the health human resource needs in some provinces of the Central and Highlands region. Subjects and Methods: This is a cross-sectional descriptive study on health workers working at Provincial Health Services of Quang Tri, Thua Thien Hue, Khanh Hoa and Dak Lak based on the health workforce data. Estimation of health human resource needs is calculated based on quotas assigned by government, the rate of annual population growth, and the number of health workers retired. Results: The estimated number of doctors to be recruited in 2015-2020 are 148 doctors in Quang Tri, 1028 in Dak Lak, 614 in Khanh Hoa, and 516 in Thua Thien Hue. Estimated number of pharmacist (bachelor degree) to be recruited in 2015-2020: 99 in Quang Tri, 404 in Dak Lak, 235 in Khanh Hoa, and 178 in Thua Thien Hue. Key words: health human resource, human needs, Central and Highlands