The main purpose of this study is to examine the effects of health workers’ levels of work commitment on the levels of depression and burnout. Having this purpose in mind, a questionnaire consisting of personal information form, work commitment scale, burnout scale and depression scale was conducted with 266 health workers of İstanbul Kartal Training and Research Hospital in May 2013. Data obtained from questionnaires were analyzed by SPSS 17,0 statistical software. Correlation analysis was utilized in order to determine the relationships among work commitment, burnout and depression levels of health workers whereas regression analysis was utilized in order to determine the effects of health workers’ levels of work commitment on the levels of depression and burnout. According to the results, it has been found that there are statistically relevant relationships among work commitment, burnout and depression levels of health workers. It has been concluded that the more health workers’ levels of work commitment increase, their levels of depression and burnout decrease.