COVID-19 Pandemic has a huge influence on the learning process worldwide. To maintain student academic progress, learning activities were converted to distance learning to control the further spread of the COVID-19 virus. During this period several studies around the world were conducted to assess the effectiveness of distance learning. The results of these studies showed different perspectives, some of the students preferred e-learning while other preferred traditional methods. The aim of this study was to assess the experience of undergraduate nursing students who used distance learning during the COVID-19 pandemic. A quantitative, cross-sectional design was used to conduct the study. A convenient sampling approach was used to collect the data electronically via self-reported questionnaires. The study included 328 participants. The average score of the effectiveness domain was (2.58±0.68, medium level), and the satisfaction domain was (2.56±0.54, medium level). The results indicate that technical issues were the most significant barrier (75.6%) to distance learning, followed by physical problems, and decreased access to technological devices. Savings in transportation costs (74.1%), savings in time (71.6%), and the opportunity to review recorded lectures (67.4%) were the benefits of distance learning reported by nursing students during the COVID-19 pandemic. Most of the nursing students reported a positive preference for distance learning. Technical issues were the most significant barrier while decreased transportation costs were the most significant facilitator. These findings were consistent with other studies from different settings. Further research is needed to build upon these findings.