scholarly journals KATP Channel Knockout Mice Crossbred with Transgenic Mice Expressing a Dominant-negative Form of Human Insulin Receptor Have Glucose Intolerance but not Diabetes

2004 ◽  
Vol 51 (2) ◽  
pp. 133-144 ◽  
Author(s):  
Yoshiko KANEZAKI ◽  
Toshiyuki OBATA ◽  
Rie MATSUSHIMA ◽  
Asako MINAMI ◽  
Tomoyuki YUASA ◽  
...  
Keyword(s):  
Transgenic Mice ◽  
Insulin Receptor ◽  
Human Insulin ◽  
Glucose Intolerance ◽  
Knockout Mice ◽  
Katp Channel ◽  
Dominant Negative ◽  
Human Insulin Receptor ◽  
Dominant Negative Form ◽  
Negative Form

scholarly journals Expression of a dominant-negative mutant human insulin receptor in the muscle of transgenic mice.

1994 ◽  
Vol 269 (23) ◽  
pp. 16034-16040
Author(s):  
P.Y. Chang ◽  
H. Benecke ◽  
Y. Le Marchand-Brustel ◽  
J. Lawitts ◽  
D.E. Moller
Keyword(s):  
Transgenic Mice ◽  
Insulin Receptor ◽  
Human Insulin ◽  
Dominant Negative ◽  
Dominant Negative Mutant ◽  
Human Insulin Receptor ◽  
Negative Mutant

Hyperinsulinemia but No Diabetes in Transgenic Mice Homozygously Expressing the Tyrosine Kinase-Deficient Human Insulin Receptor

1997 ◽  
Vol 240 (2) ◽  
pp. 446-451 ◽  
Author(s):  
Lihong Wang ◽  
Naoko Muromoto ◽  
Hideki Hayashi ◽  
Yasumasa Mitani ◽  
Hisanori Uehara ◽  
...  
Keyword(s):  
Transgenic Mice ◽  
Tyrosine Kinase ◽  
Insulin Receptor ◽  
Human Insulin ◽  
Human Insulin Receptor

FGF suppresses apoptosis and induces differentiation of fibre cells in the mouse lens

Development ◽  
1995 ◽  
Vol 121 (12) ◽  
pp. 4383-4393 ◽  
Author(s):  
R.L. Chow ◽  
G.D. Roux ◽  
M. Roghani ◽  
M.A. Palmer ◽  
D.B. Rifkin ◽  
...  
Keyword(s):  
Growth Factor ◽  
Transgenic Mice ◽  
Dominant Negative ◽  
Fgf Receptor ◽  
Fibre Cell ◽  
Dominant Negative Form ◽  
Lens Fibre ◽  
Mouse Lens ◽  
Negative Form

To determine whether fibroblast growth factor (FGF) has a role in lens development, we have generated transgenic mice expressing a dominant-negative form of the murine FGF receptor-1 (FGFRDN) in the lens. Using the fibre cell-specific alpha A-crystallin promoter to express the FGFRDN, we have asked whether FGF is required for fibre cell differentiation. The transgenic mice display diminished differentiation of fibre cells as indicated by their reduced elongation. In addition, transgenic lenses have an unusual refractile anomaly that morphological and biochemical data show results from the apoptosis of fibre cells in the central region of the lens. These results show that lens fibre cells are dependent on FGF for their survival and differentiation, and demonstrate that growth factor deprivation in vivo can lead to apoptosis.

Muscle-specific expression of human insulin receptor in transgenic mice

Diabetes ◽  
1993 ◽  
Vol 42 (1) ◽  
pp. 206-212 ◽  
Author(s):  
H. Benecke ◽  
J. S. Flier ◽  
N. Rosenthal ◽  
K. Siddle ◽  
H. H. Klein ◽  
...  
Keyword(s):  
Transgenic Mice ◽  
Insulin Receptor ◽  
Human Insulin ◽  
Specific Expression ◽  
Human Insulin Receptor

Defective thymocyte proliferation and IL-2 production in transgenic mice expressing a dominant-negative form of CREB

Nature ◽  
1996 ◽  
Vol 379 (6560) ◽  
pp. 81-85 ◽  
Author(s):  
Kevin Barton ◽  
Natarajan Muthusamy ◽  
Monchai Chanyangam ◽  
Christopher Fischer ◽  
Cynthia Clendenin ◽  
...  
Keyword(s):  
Transgenic Mice ◽  
Dominant Negative ◽  
Thymocyte Proliferation ◽  
Dominant Negative Form ◽  
Negative Form

Muscle-Specific Expression of Human Insulin Receptor in Transgenic Mice

Diabetes ◽  
1993 ◽  
Vol 42 (1) ◽  
pp. 206-212 ◽  
Author(s):  
H. Benecke ◽  
J. S. Flier ◽  
N. Rosenthal ◽  
K. Siddle ◽  
H. H. Klein ◽  
...  
Keyword(s):  
Transgenic Mice ◽  
Insulin Receptor ◽  
Human Insulin ◽  
Specific Expression ◽  
Human Insulin Receptor

scholarly journals Retinoic acid receptor ? dominant negative form causes steatohepatitis and liver tumors in transgenic mice

Hepatology ◽  
2004 ◽  
Vol 40 (2) ◽  
pp. 366-375 ◽  
Author(s):  
Atsushi Yanagitani ◽  
Sadako Yamada ◽  
Sakiko Yasui ◽  
Takashi Shimomura ◽  
Rie Murai ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Transgenic Mice ◽  
Liver Tumors ◽  
Retinoic Acid Receptor ◽  
Dominant Negative ◽  
Acid Receptor ◽  
Dominant Negative Form ◽  
Negative Form
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