Physiology and pathophysiology of the RANKL/RANK system

2010 ◽  
Vol 391 (12) ◽  
Author(s):  
Reiko Hanada ◽  
Toshikatsu Hanada ◽  
Josef M. Penninger

Abstract The TNF family molecule RANKL and its receptor RANK are key regulators of bone remodeling, lymph node formation, and mammary gland development during pregnancy. RANKL and RANK are also expressed in the central nervous systems (CNS). However, the functional relevance of RANKL/RANK in the brain was entirely unknown. Recently, our group reported that the RANKL/RANK signaling pathway has an essential role in the central regulation of body temperature via the prostaglandin axis. This review discusses novel aspects of the RANKL/RANK system as key regulators of fever and female basal body temperature in the CNS.

Cell ◽  
2001 ◽  
Vol 107 (6) ◽  
pp. 763-775 ◽  
Author(s):  
Yixue Cao ◽  
Giuseppina Bonizzi ◽  
Tiffany N. Seagroves ◽  
Florian R. Greten ◽  
Randall Johnson ◽  
...  

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