First trimester concentrations of the TTR-RBP4-retinol complex components as early markers of insulin-treated gestational diabetes mellitus

AbstractThe objective of the study was to investigate the relationship between first trimester maternal serum levels of the TTR-RBP4-ROH complex components and the later insurgence of an altered glucose metabolism during pregnancy.Retrospective case control study including 96 patients between the 12th and 14th week of gestation, 32 that developed gestational diabetes mellitus (GDM), respectively, 21 non-insulin-treated (dGDM) and 11 insulin-treated (iGDM), 20 large for gestational age fetuses (LGA) without GDM and 44 patients with normal outcome as control. Serum concentrations of RBP4 and TTR were assessed by ELISA; serum concentration of ROH by reverse-phase high performance liquid chromatography (rpHPLC). The molecular heterogeneity of TTR and RBP4 was analyzed after immunoprecipitation by matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF-MS).iGDM patients were characterized by reduced TTR, RBP4 and ROH compared to controls (respectively, iGDM vs. controls, mean±SD: TTR 3.96±0.89 μmol/L vs. 4.68±1.21 μmol/L, RBP4 1.13±0.25 μmol/L vs. 1.33±0.38 μmol/L and ROH 1.33±0.17 μmol/L vs. 1.62±0.29 μmol/L, p<0.05). TTR containing Gly10 in place of Cys10 was lower in the iGDM group (p<0.05) compared to controls. In the final logistic regression model ROH significantly predicted the diagnosis of iGDM (OR 0.93, 95% CI 0.87–0.98, p<0.05).First trimester maternal serum ROH, RBP4 and TTR represent potential biomarkers associated with the development of iGDM.

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The Role of Maternal Serum Triglycerides in Prediction of Large-For Gestational-Age in Pregestational and Gestational Diabetes Mellitus

Journal of Gynecology and Womens Health ◽

10.19080/jgwh.2020.17.555974 ◽

2020 ◽

Vol 17 (5) ◽

Author(s):

Bassem A Islam

Keyword(s):

Diabetes Mellitus ◽

Gestational Diabetes ◽

Gestational Diabetes Mellitus ◽

Gestational Age ◽

Maternal Serum ◽

Large For Gestational Age ◽

Serum Triglycerides

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364: First-trimester maternal serum pregnancy associated protein-A (PAPP-A) and subsequent gestational diabetes mellitus (GDM)

American Journal of Obstetrics and Gynecology ◽

10.1016/j.ajog.2010.10.382 ◽

2011 ◽

Vol 204 (1) ◽

pp. S148

Author(s):

Methodius Tuuli ◽

Rachael Bradshaw ◽

Yan Zhong ◽

George Macones ◽

Anthony Odibo

Keyword(s):

Diabetes Mellitus ◽

Gestational Diabetes ◽

Gestational Diabetes Mellitus ◽

Protein A ◽

First Trimester ◽

Maternal Serum

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Can first trimester maternal serum follistatin like 3 levels predict developing gestational diabetes mellitus?

The Journal of Maternal-Fetal & Neonatal Medicine ◽

10.1080/14767058.2016.1235695 ◽

2016 ◽

Vol 30 (16) ◽

pp. 1968-1971 ◽

Cited By ~ 1

Author(s):

Ayse Yasemin Karageyim Karsidag ◽

Yunus Emre Purut ◽

Esra Esim Buyukbayrak ◽

Asuman Orcun ◽

Mehmet Menke

Keyword(s):

Diabetes Mellitus ◽

Gestational Diabetes ◽

Gestational Diabetes Mellitus ◽

First Trimester ◽

Maternal Serum

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First Trimester Combined Test (FTCT) as a Predictor of Gestational Diabetes Mellitus

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph16193654 ◽

2019 ◽

Vol 16 (19) ◽

pp. 3654 ◽

Cited By ~ 3

Author(s):

Federica Visconti ◽

Paola Quaresima ◽

Eusebio Chiefari ◽

Patrizia Caroleo ◽

Biagio Arcidiacono ◽

...

Keyword(s):

Diabetes Mellitus ◽

Logistic Regression ◽

Gestational Diabetes ◽

Gestational Diabetes Mellitus ◽

Pregnant Women ◽

First Trimester ◽

Maternal Serum ◽

Fetal Aneuploidy ◽

Combined Test ◽

Β Hcg

Background—The first trimester combined test (FTCT) is an effective screening tool to estimate the risk of fetal aneuploidy. It is obtained by the combination of maternal age, ultrasound fetal nuchal translucency (NT) measurement, and the maternal serum markers free β-human chorionic gonadotropin (β-hCG) and pregnancy-associated plasma protein A (PAPP-A). However, conflicting data have been reported about the association of FTCT, β-hCG, or PAPP-A with the subsequent diagnosis of gestational diabetes mellitus (GDM). Research design and methods—2410 consecutive singleton pregnant women were retrospectively enrolled in Calabria, Southern Italy. All participants underwent examinations for FTCT at 11–13 weeks (plus 6 days) of gestation, and screening for GDM at 16–18 and/or 24–28 weeks of gestation, in accordance with current Italian guidelines and the International Association Diabetes Pregnancy Study Groups (IADPSG) glycemic cut-offs. Data were examined by univariate and logistic regression analyses. Results—1814 (75.3%) pregnant women were normal glucose tolerant, while 596 (24.7%) were diagnosed with GDM. Spearman univariate analysis demonstrated a correlation between FTCT values and subsequent GDM diagnosis (ρ = 0.048, p = 0.018). The logistic regression analysis showed that women with a FTCT <1:10000 had a major GDM risk (p = 0.016), similar to women with a PAPP-A <1 multiple of the expected normal median (MoM, p = 0.014). Conversely, women with β-hCG ≥2.0 MoM had a reduced risk of GDM (p = 0.014). Conclusions—Our findings indicate that GDM susceptibility increases with fetal aneuploidy risk, and that FTCT and its related maternal serum parameters can be used as early predictors of GDM.

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