MATERNAL SERUM VISFATIN IN THE FIRST TRIMESTER OF PREGNANCY AND ITS LINK TO GESTATIONAL DIABETES MELLITUS

AbstractThe objective of the study was to investigate the relationship between first trimester maternal serum levels of the TTR-RBP4-ROH complex components and the later insurgence of an altered glucose metabolism during pregnancy.Retrospective case control study including 96 patients between the 12th and 14th week of gestation, 32 that developed gestational diabetes mellitus (GDM), respectively, 21 non-insulin-treated (dGDM) and 11 insulin-treated (iGDM), 20 large for gestational age fetuses (LGA) without GDM and 44 patients with normal outcome as control. Serum concentrations of RBP4 and TTR were assessed by ELISA; serum concentration of ROH by reverse-phase high performance liquid chromatography (rpHPLC). The molecular heterogeneity of TTR and RBP4 was analyzed after immunoprecipitation by matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF-MS).iGDM patients were characterized by reduced TTR, RBP4 and ROH compared to controls (respectively, iGDM vs. controls, mean±SD: TTR 3.96±0.89 μmol/L vs. 4.68±1.21 μmol/L, RBP4 1.13±0.25 μmol/L vs. 1.33±0.38 μmol/L and ROH 1.33±0.17 μmol/L vs. 1.62±0.29 μmol/L, p<0.05). TTR containing Gly10 in place of Cys10 was lower in the iGDM group (p<0.05) compared to controls. In the final logistic regression model ROH significantly predicted the diagnosis of iGDM (OR 0.93, 95% CI 0.87–0.98, p<0.05).First trimester maternal serum ROH, RBP4 and TTR represent potential biomarkers associated with the development of iGDM.

Download Full-text

Association of Complete Blood Count Parameters with Gestational Diabetes Mellitus

Gynecology Obstetrics and Reproductive Medicine ◽

10.21613/gorm.2016.649 ◽

2017 ◽

pp. 1 ◽

Cited By ~ 1

Author(s):

Zehra Vural Yılmaz ◽

Elif Yılmaz ◽

Bilal İçer ◽

Tuncay Küçüközkan

Keyword(s):

Diabetes Mellitus ◽

Gestational Diabetes ◽

Gestational Diabetes Mellitus ◽

Blood Count ◽

Complete Blood Count ◽

First Trimester ◽

Red Cell ◽

Platelet Volume ◽

Distribution Width ◽

First Trimester Of Pregnancy

Objective: The aim of this study is to evaluate the relationship between hematological changes in early pregnancy using complete blood count parameters and gestational diabetes mellitus. Study Design: One hundred pregnant with gestational diabetes mellitus and one hundred healthy pregnant were included in the study. Blood samples for routine complete blood count parameters in first trimester of pregnancy were analyzed. Results: In the gestational diabetes mellitus group white blood cell, platelet count, neutrophil and lymphocyte count, mean platelet volume, red cell distribution width were significantly higher than control group. However, there was no significant difference between groups with regard to neutrophil to lymphocyte ratio and platelet to lymphocyte ratio levels. In binary logistic regression analysis; first trimester mean platelet volume and red cell distribution width values were found to be independently associated with diagnosis of gestational diabetes mellitus. Conclusion: This study demonstrates that hematological parameters in first trimester of pregnancy are closely associated with gestational diabetes mellitus. The parameters that are routinely and automatically calculated in complete blood count; may be used to predict gestational diabetes mellitus.

Download Full-text

Criteria for Screening and Diagnosis of Gestational Diabetes Mellitus in the First Trimester of Pregnancy

Fetal Diagnosis and Therapy ◽

10.1159/000324684 ◽

2011 ◽

Vol 30 (2) ◽

pp. 108-115 ◽

Cited By ~ 19

Author(s):

Walter Plasencia ◽

Raquel Garcia ◽

Susana Pereira ◽

Ranjit Akolekar ◽

Kypros H. Nicolaides

Keyword(s):

Diabetes Mellitus ◽

Gestational Diabetes ◽

Gestational Diabetes Mellitus ◽

First Trimester ◽

First Trimester Of Pregnancy ◽

Screening And Diagnosis

Download Full-text

Lower Adiponectin Levels at First Trimester of Pregnancy Are Associated With Increased Insulin Resistance and Higher Risk of Developing Gestational Diabetes Mellitus

Diabetes Care ◽

10.2337/dc12-1731 ◽

2013 ◽

Vol 36 (6) ◽

pp. 1577-1583 ◽

Cited By ~ 67

Author(s):

M. Lacroix ◽

M.-C. Battista ◽

M. Doyon ◽

J. Menard ◽

J.-L. Ardilouze ◽

...

Keyword(s):

Diabetes Mellitus ◽

Insulin Resistance ◽

Gestational Diabetes ◽

Gestational Diabetes Mellitus ◽

First Trimester ◽

First Trimester Of Pregnancy

Download Full-text

The association of first trimester high blood pressure and risk of gestational diabetes mellitus

Arterial’naya Gipertenziya (Arterial Hypertension) ◽

10.18705/1607-419x-2012-18-1-67-72 ◽

2012 ◽

Vol 18 (1) ◽

pp. 67-72

Author(s):

P. V. Popova ◽

A. S. Gerasimov ◽

E. N. Kravchuk ◽

E. S. Shelepova ◽

E. M. Ryazantseva ◽

...

Keyword(s):

Diabetes Mellitus ◽

Blood Pressure ◽

Gestational Diabetes ◽

Gestational Diabetes Mellitus ◽

Fold Increase ◽

First Trimester ◽

Elevated Blood Pressure ◽

Elevated Blood ◽

Increased Risk ◽

First Trimester Of Pregnancy

Objective. To determine the relationship between blood pressure measured during the first trimester of pregnancy and the risk of the development of gestational diabetes mellitus. Design and methods. A total of 209 pregnant women were screened for gestational diabetes mellitus between weeks 24 and 28 of gestation, as defined by WHO criteria. Blood pressure, weight and waist circumference data were obtained by review of the medical records. Results. An elevated blood pressure at first trimester of pregnancy was associated with a six-fold increase in the risk of the development of gestational diabetes mellitus (OR = 5.8, 95 % CI 1.9-17.5, p = 0.001) compared with non-hypertensive women. Arterial hypertension (including controlled forms) in the first trimester of pregnancy was followed by a three-fold (OR = 3.04, 95 % CI 1.5-6.3) increase in the risk of gestational diabetes mellitus compared with non-hypertensive women (p = 0.005). Conclusion. Obtained data indicate that women with elevated blood pressure in the first trimester of pregnancy have an increased risk of the development of gestational diabetes mellitus.

Download Full-text