scholarly journals Indirect Estimation of Clinical Chemical Reference Intervals from Total Hospital Patient Data: Application of a Modified Bhattacharya Procedure

1985 ◽  
Vol 23 (12) ◽  
Author(s):  
H. Baadenhuijsen ◽  
Smit J. C.
Keyword(s):  
Reference Intervals ◽  
Patient Data ◽  
Hospital Patient ◽  
Total Hospital ◽  
Indirect Estimation ◽  
Data Application ◽  
Clinical Chemical

Use of total patient data for indirect estimation of reference intervals for 40 clinical chemical analytes in Turkey

2006 ◽  
Vol 44 (7) ◽  
Author(s):  
Yesim Ozarda Ilcol ◽  
Diler Aslan
Keyword(s):  
Binding Capacity ◽  
Clinical Chemistry ◽  
Reference Intervals ◽  
Thyroid Stimulating Hormone ◽  
Patient Data ◽  
Clinical Chemical ◽  
Laboratory Results ◽  
Total Triiodothyronine ◽  
Iron Binding Capacity ◽  
Indirect Reference

AbstractIn the present study we used patient data to calculate laboratory-specific indirect reference intervals. These values were compared with reference intervals obtained for a healthy group according to recommendations of the International Federation of Clinical Chemistry and Laboratory Medicine and manufacturer suggestions. Laboratory results (422,919 records) from all subjects of 18–45years of age over a 1-year period were retrieved from our laboratory information system and indirect reference intervals for 40 common analytes were estimated using a modified Bhattacharya procedure. Indirect reference intervals for most of the biochemical analytes were comparable, with small differences in lower [alkaline phosphatase (ALP) (male), alanine aminotransferase (ALT), creatine kinase, iron (male), total iron-binding capacity, folic acid, calcium (female), lactate dehydrogenase (LDH), lipoprotein (a) [Lp(a)], thyroid-stimulating hormone (TSH), total triiodothyronine (TClin Chem Lab Med 2006;44:867–76.

Validity of establishing pediatric reference intervals based on hospital patient data: A comparison of the modified Hoffmann approach to CALIPER reference intervals obtained in healthy children

2014 ◽  
Vol 47 (3) ◽  
pp. 166-172 ◽  
Author(s):  
Julie L.V. Shaw ◽  
Ashley Cohen ◽  
Danijela Konforte ◽  
Tina Binesh-Marvasti ◽  
David A. Colantonio ◽  
...  
Keyword(s):  
Reference Intervals ◽  
Patient Data ◽  
Healthy Children ◽  
Hospital Patient

scholarly journals Diurnal variation of leukocyte counts affects the indirect estimation of reference intervals

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Antje Torge ◽  
Rainer Haeckel ◽  
Mustafa Özcürümez ◽  
Alexander Krebs ◽  
Ralf Junker
Keyword(s):  
Diurnal Variation ◽  
Indirect Method ◽  
Venous Blood ◽  
Direct Methods ◽  
Reference Intervals ◽  
Indirect Methods ◽  
Indirect Estimation ◽  
Late Afternoon ◽  
Reference Limits ◽  
Leukocyte Counts

Abstract It has been observed that the estimation of reference intervals of leukocytes in whole venous blood leads to higher upper reference limits (uRLs) with indirect methods than has been reported in the literature determined by direct approaches. This phenomenon was reinvestigated with a newer, more advanced indirect method, and could be confirmed. Furthermore, a diurnal variation was observed with lower values during the morning and higher values in the late afternoon and at night. This observation can explain why indirect approaches using samples collected during 24 h lead to higher uRLs than direct methods applied on samples collected presumably in the morning.

A new indirect estimation of reference intervals: truncated minimum chi-square (TMC) approach

2019 ◽  
Vol 57 (12) ◽  
pp. 1933-1947 ◽  
Author(s):  
Werner Wosniok ◽  
Rainer Haeckel
Keyword(s):  
Detection Limit ◽  
Simulated Data ◽  
Reference Interval ◽  
Reference Intervals ◽  
Skewed Data ◽  
Chi Square ◽  
Indirect Methods ◽  
Indirect Estimation ◽  
Estimated Parameters ◽  
Data Files

Abstract All known direct and indirect approaches for the estimation of reference intervals (RIs) have difficulties in processing very skewed data with a high percentage of values at or below the detection limit. A new model for the indirect estimation of RIs is proposed, which can be applied even to extremely skewed data distributions with a relatively high percentage of data at or below the detection limit. Furthermore, it fits better to some simulated data files than other indirect methods. The approach starts with a quantile-quantile plot providing preliminary estimates for the parameters (λ, μ, σ) of the assumed power normal distribution. These are iteratively refined by a truncated minimum chi-square (TMC) estimation. The finally estimated parameters are used to calculate the 95% reference interval. Confidence intervals for the interval limits are calculated by the asymptotic formula for quantiles, and tolerance limits are determined via bootstrapping. If age intervals are given, the procedure is applied per age interval and a spline function describes the age dependency of the reference limits by a continuous function. The approach can be performed in the statistical package R and on the Excel platform.

Researching Hospital Patient Data to Enhance Operational Management

2004 ◽  
Vol 32 (1) ◽  
pp. 13-16 ◽  
Author(s):  
Liza Heslop ◽  
Brendon Gardner ◽  
Dean Athan ◽  
Donna Diers ◽  
Catherine Taylor
Keyword(s):  
Patient Data ◽  
Hospital Patient ◽  
Operational Management

scholarly journals Thyroxine, thyrotropin, and age in a euthyroid hospital patient population

1997 ◽  
Vol 43 (11) ◽  
pp. 2143-2148 ◽  
Author(s):  
Richard Davey
Keyword(s):  
Thyroid Disease ◽  
Clinical Condition ◽  
Patient Population ◽  
Reference Intervals ◽  
Hospital Patient ◽  
Free T4 ◽  
Diagnostic Algorithms ◽  
Age Related ◽  
Range Of Variation

Abstract The diagnosis of thyroid disease now often can be achieved reliably by measuring thyrotropin (TSH) alone. Thyroxine (T4), triiodothyronine, and other analytes are only needed if TSH and the accompanying clinical condition are discordant. We describe here work that confirms the age independence of TSH in both inpatient and outpatient euthyroid hospital populations between ages 20 and at least 80 years, and demonstrates that although free T4 does vary with age, the range of variation remains within the T4reference interval. On this basis, TSH-based thyroid diagnostic algorithms can be used reliably in adults without reference to age-related reference intervals.

Indirect Estimation of Reference Intervals for Thyroid Parameters

2014 ◽  
Vol 60 (07/2014) ◽  
Author(s):  
Neda Milinković ◽  
Svetlana Ignjatović ◽  
Miloš Žarković ◽  
Branimir Radosavljević ◽  
Nada Majkić-singh
Keyword(s):  
Reference Intervals ◽  
Indirect Estimation
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