Design and optimization of intelligent cleaning robot in chemical fiber textile workshop

From artificial turf to medical fibers, chemical fiber materials have become a new type of material, and chemical fiber textile materials have long gone beyond the scope of clothing. They play an important role in the fields of medical, clinical, chemical and other fields. The handling is not optimistic. Therefore, this article analyzes the working principle and process of the intelligent cleaning machine, and uses this as the theoretical basis to design the structure of the intelligent cleaning robot for the textile workshop, and then proceed from the functionality and aesthetics to its appearance design and optimization. A simple but distinctive appearance, while also greatly improving work efficiency.

Evaluation of Inner Exposure of Horses to Zearalenone (ZEN), Deoxynivalenol (DON) and Their Metabolites in Relation to Colic and Health-Related Clinical-Chemical Traits

Mycotoxin contaminated feed has been associated with colic of horses caused by intestinal disorders. Whether such disease conditions alter the intestinal toxin metabolism and transfer across a compromised mucosal barrier is unknown. A screening approach was used to relate blood residue levels of DON, ZEN and their metabolites to the status of the horses (sick vs. healthy). A total of 55 clinically healthy horses from 6 different farms with varying feeding background served as control for sick horses (N = 102) hospitalized due to colic. ZEN, alpha-zearalenol (ZEL), beta-ZEL and DON were detectable in peripheral blood as indicators for the inner exposure with significant farm effects for alpha- and beta-ZEL. However, the levels in sick horses were similar to all farms. Moreover, the proportion of beta-ZEL of all detected ZEN metabolites as an indicator for the degree of metabolism of ZEN was not different for sick horses but differed amongst the control farms. Although the incidence of DON in blood was generally low and not significantly different amongst healthy and sick horses, the positive samples were nearly exclusively found in sick horses suggesting either a higher toxin transfer, an association of DON with the development of colic or a different feeding background.

Analysis of the sex-specific variability of blood parameters in data sets of the Mouse Phenome Database

Objective The use of mice as animal models in biomedical research allows the standardization of genetic background and environmental conditions, which both affect phenotypic variability. As the use of both sexes in experiments is strongly recommended, sex-specific phenotypic variability is discussed with regard to putative consequences on the group size which is necessary for achieving valid and reproducible results. In this study, the sex-specific variability of 25 clinical chemical and hematological parameters which represent a comprehensive blood screen of laboratory mice, was analyzed in data sets which have been submitted to the Mouse Phenome Database. Results The overall analysis comprising all 25 clinical chemical and hematological parameters showed no evidence for substantial and robust general sex-specific variability. A large range of the ratio of the female and male coefficient of variation (CV) was found for every parameter among the respective strain data sets. This clearly demonstrated the appearance of unpredictable major interactions between genotype and environment regarding the sex-specific variability of the blood parameters analyzed.

El laboratorio como un espacio para propiciar el aprendizaje significativo para los cursos por competencias de análisis cuantitativo en nivel medio superior y de química analítica ii del nivel superior utilizando el modelo didáctico la actividad integrad

RESUMEN Cuando se imparten asignaturas curriculares bajo la estrategia, además del objetivo de que el alumno aprenda a aprender (Estévez 2002) y tenga determinadas actitudes y habilidades para lograr un aprendizaje significativo (Ausubel), también es necesario establecer diferentes estrategias para poder evaluar pedagógicamente el desempeño del alumno. El modelo de enseñanza que se presenta permite diseñar la enseñanza como base del uso de estrategias cognitivas (Estévez 2002) En cuanto a las condiciones implicadas en el modelo, éstas son la participación activa del alumno: la mediación, orientación y seguimiento del aprendizaje por parte del profesor; el aprovechamiento de los errores y la retroalimentación como fuentes de aprendizaje y la secuenciación de la enseñanza para la obtención del conocimiento objetivo (Estévez 2002) La exigencia de que los alumnos alcancen sus logros de forma individual y sólo a través de su propio esfuerzo es manejarse bajo el paradigma de la teoría del aprendizaje por competencias (Barr 1995) Las asignaturas como análisis cuantitativo de los planes de estudio del Técnico en Laboratorio Clínico y Química Analítica en la licenciatura de Químico Biólogo Clínico, tienen en común que forman parte del proceso que utiliza diferentes métodos para analizar una muestra y cuantificar sus componentes, por lo que son cursos teórico/prácticos. Para evaluar completamente al alumno, se diseña una actividad integradora para cada curso, que consiste en lo siguiente: El alumno retomará los conceptos aprendidos en sus cursos anteriores como: Química I y II, Matemáticas, Análisis Cualitativo y Cuantitativo y en el caso de Análisis Cualitativo para el Técnico en Laboratorio Clínico y las asignaturas de: Química General y Química Analítica I en el caso de Química Analítica II del QCB. ABSTRACT When curricular subjects are taught under the strategy, in addition to the aim that the student is intended to learn to learn (Estevez 2002) and have certain attitudes and skills to achieve meaningful learning (Ausubel), it is also necessary to establish different strategies to be able to evaluate pedagogically the student's performance. The teaching model presented here allows to design teaching as the basis of the use of cognitive strategies (Estevez 2002) As for the conditions involved in the model, these are the active participation of the student: mediation, guidance and monitoring of learning by the teacher; leveraging errors and feedback as sources of learning and sequencing teaching to obtain the goal knowledge (Estevez 2002) The requirement that students achieve their achievements individually and only through their own efforts is to manage ourselves under the paradigm of competency learning theory (Barr 1995) The subjects as quantitative analysis of the curricula of the Technician in Clinical Laboratory and Analytical Chemistry in the bachelor's degree of Clinical Chemical Biologist, have in common that they are part of the process that uses different methods to analyze a sample and quantify its components, for which they are theoretical /practical courses. To fully evaluate the student, an integrative activity is designed for each course, which consists of the following: The student will return to the concepts learned in his past courses such as: Chemistry I and II, Mathematics, Qualitative and Quantitative Analysis and in the case of Qualitative Analysis for the Technician in Clinical Laboratory and the subjects of: General Chemistry and Analytical Chemistry I in the case of Analytical Chemistry II of the QCB.

Copper Imbalance in Alzheimer’s Disease and Its Link with the Amyloid Hypothesis: Towards a Combined Clinical, Chemical, and Genetic Etiology

The cause of Alzheimer’s disease (AD) is incompletely defined. To date, no mono-causal treatment has so far reached its primary clinical endpoints, probably due to the complexity and diverse neuropathology contributing to the neurodegenerative process. In the present paper, we describe the plausible etiological role of copper (Cu) imbalance in the disease. Cu imbalance is strongly associated with neurodegeneration in dementia, but a complete biochemical etiology consistent with the clinical, chemical, and genetic data is required to support a causative association, rather than just correlation with disease. We hypothesize that a Cu imbalance in the aging human brain evolves as a gradual shift from bound metal ion pools, associated with both loss of energy production and antioxidant function, to pools of loosely bound metal ions, involved in gain-of-function oxidative stress, a shift that may be aggravated by chemical aging. We explain how this may cause mitochondrial deficits, energy depletion of high-energy demanding neurons, and aggravated protein misfolding/oligomerization to produce different clinical consequences shaped by the severity of risk factors, additional comorbidities, and combinations with other types of pathology. Cu imbalance should be viewed and integrated with concomitant genetic risk factors, aging, metabolic abnormalities, energetic deficits, neuroinflammation, and the relation to tau, prion proteins, α-synuclein, TAR DNA binding protein-43 (TDP-43) as well as systemic comorbidity. Specifically, the Amyloid Hypothesis is strongly intertwined with Cu imbalance because amyloid-β protein precursor (AβPP)/Aβ are probable Cu/Zn binding proteins with a potential role as natural Cu/Zn buffering proteins (loss of function), and via the plausible pathogenic role of Cu-Aβ.

Identification Of Paraproteins Via Serum Immunofixation or Serum Immunosubtraction and Immunoturbidimetric Quantitation of Serum Immunoglobulins in the Laboratory Testing for Monoclonal Gammopathies: A Comparison of Methods

Context.— In laboratory testing for monoclonal gammopathies, paraproteins are identified via serum immunofixation or serum immunosubtraction and immunoturbidimetric quantitation of serum immunoglobulins is often used. Objective.— To evaluate methodic differences between serum immunofixation and serum immunosubtraction as well as in the quantitation of serum immunoglobulins on different clinical chemical platforms. Design.— Three hundred twenty-two unique routine patient samples were blinded and used for comparison between serum immunofixation on Sebia's HYDRASIS 2 and serum immunosubtraction on Sebia's CAPILLARYS 2 as well as between quantitation results of immunoglobulin A, G, and M on Abbott's ARCHITECT c16000PLUS and Roche's Cobas c 502 module. Microsoft Excel 2019 with the add-on Abacus 2.0 and MedCalc were used for statistical analysis and graphic depiction via bubble diagram, Passing-Bablok regressions, and Bland-Altman plots. Results.— The median age of patients was 75 years and samples with paraproteinemia were nearly evenly split between sexes. Paraprotein identification differed remarkably between immunofixation and immunosubtraction. Quantitation of serum immunoglobulins showed higher values on Abbott's ARCHITECT c16000PLUS when compared with Roche's Cobas c 502 module. Conclusions.— Identification of paraproteins via serum immunosubtraction is inferior to serum immunofixation, which can have implications on the diagnosis and monitoring of patients with monoclonal gammopathy. If immunoturbidimetric quantitation of immunoglobulins is used for follow-up, the same clinical-chemical platform should be used consistently.

COL2A1 and Caspase-3 as Promising Biomarkers for Osteoarthritis Prognosis in an Equus asinus Model

Osteoarthritis (OA) is one of the most degenerative joint diseases in both human and veterinary medicine. The objective of the present study was the early diagnosis of OA in donkeys using a reliable grading of the disease based on clinical, chemical, and molecular alterations. OA was induced by intra-articular injection of 25 mg monoiodoacetate (MIA) as a single dose into the left radiocarpal joint of nine donkeys. Animals were clinically evaluated through the assessment of lameness score, radiographic, and ultrasonographic findings for seven months. Synovial fluid and cartilage samples were collected from both normal and diseased joints for the assessment of matrix metalloproteinases (MMPs) activity, COL2A1 protein expression level, and histopathological and immunohistochemical analysis of Caspase-3. Animals showed the highest lameness score post-induction after one week then decreased gradually with the progression of radiographical and ultrasonographic changes. MMP activity and COL2A1 and Caspase-3 expression increased, accompanied by articular cartilage degeneration and loss of proteoglycan. OA was successfully graded in Egyptian donkeys, with the promising use of COL2A1and Caspase-3 for prognosis. However, MMPs failed to discriminate between early and late grades of OA.