Sources of variation and reference intervals for serum cystatin C in a healthy Japanese adult population

Background. The aim of the present study was to examine sources of variation for serum cystatin C in a healthy Greek population.Methods. Cystatin C together with basic clinical chemistry tests was measured in a total of 490 adults (46±16 yrs, 40% males) who underwent an annual health check. Demographic, anthropometric, and lifestyle characteristics were recorded.Results. Higher values of cystatin C were observed among males (P=.04), participants aged over 65 years (P<.001), current smokers (P=.001) and overweight/obese participants (P=.03). On the contrary, alcohol consumption and physical activity seemed to have no influence on cystatin C levels (P=.61;P=.95, resp.).Conclusions. In interpreting serum cystatin C values in a healthy adult population, age, gender, Body Mass Index, and cigarette smoking need to be considered, and determination of reference ranges among distinct subpopulations seem to be prudent.

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Reference intervals for serum cystatin C and serum creatinine in an adult sub-Saharan African population

BMC Clinical Pathology ◽

10.1186/s12907-019-0086-7 ◽

2019 ◽

Vol 19 (1) ◽

Cited By ~ 2

Author(s):

Bertille Elodie Edinga-Melenge ◽

Adrienne Tchapmi Yakam ◽

Jobert Richie Nansseu ◽

Catherine Bilong ◽

Suzanne Belinga ◽

...

Keyword(s):

Serum Creatinine ◽

Cystatin C ◽

Reference Intervals ◽

African Population ◽

Serum Cystatin C ◽

Serum Cystatin ◽

Sub Saharan

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Reference Intervals and Factors Contributing to Serum Cystatin C Levels in a Chinese Population

Journal of Clinical Laboratory Analysis ◽

10.1002/jcla.20504 ◽

2012 ◽

Vol 26 (2) ◽

pp. 49-54 ◽

Cited By ~ 4

Author(s):

Dong-Dong Li ◽

Meng-Na Zou ◽

Xin Hu ◽

Mei Zhang ◽

Cheng-Yao Jia ◽

...

Keyword(s):

Cystatin C ◽

Chinese Population ◽

Reference Intervals ◽

Serum Cystatin C ◽

Serum Cystatin

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Gestational and age-specific cystatin C reference intervals for newborns in China

10.21203/rs.2.19480/v1 ◽

2019 ◽

Author(s):

Chao Tong ◽

Yalan Liu ◽

Yanqiu Wu ◽

Qiong Li ◽

Yipin Wu ◽

...

Keyword(s):

Cystatin C ◽

Newborn Infants ◽

Reference Intervals ◽

Reference Level ◽

Reference Ranges ◽

Perinatal Factors ◽

Blood Cell Count ◽

Serum Cystatin C ◽

Serum Cystatin ◽

The Mean

Abstract Backgroud : To establish reference values of serum cystatin C (CysC) in Chinese newborn infants. Methods: Serum CysC levels were measured in 1919 blood samples from 1044 newborns during their first 28 days of life. CysC levels were analyzed for association between subgroups dichotomized by postnatal age (PA) and gestational age (GA). Reference intervals of serum CysC were determined according to the PA and GA. The association between serum CysC level and other biochemical parameters as well as perinatal factors were also analyzed. Results: In this study, the mean GA was 35.75±2.90 weeks and birth weight was 2613.77±696.72 g. Reference ranges of serum CysC were determined and a general decreasing trend of CysC levels was observed as GA increased. CysC levels differed significantly among the PA and GA groups (P＜0.001). Serum CysC levels were relatively stable throughout GA, except being impacted by white blood cell count within postnatal 24 hours. Moreover, their levels always correlated positively with serum creatinine concentrations (P<0.001). Conclusion: The reference level of serum CysC should be determined according to PA and GA. In contrast to creatinine, serum CysC is a dependable index for assessing renal function in neonate, for there are rare factors influencing it.

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