Eating behavior, weight problems and eating disorders in 101 long-term survivors of childhood-onset craniopharyngioma

AbstractAs a result of hypothalamic involvement and/or treatment-related hypothalamic damage, up to 75% of childhood craniopharyngioma patients develop hypothalamic obesity.Eating behavior was analyzed in 101 survivors of childhood craniopharyngioma, recruited from 1980 to 2001 in the HIT-Endo multicenter study, and in 85 body mass index (BMI)-matched healthy controls using the Inventory for Eating Behavior and Weight Problems (IEG) and the Inventory for Eating Disorders (ESI).Severely obese patients (BMI>8 SD; n=9) presented with pathological eating behavior, more weight problems, and eating disorders, as compared to obese (BMI 3–8 SD; n=44) and normal or overweight patients (BMI<3 SD; n=48). Craniopharyngioma patients with different degrees of obesity showed similar or even less pathological findings as compared to BMI-matched normal controls.Severe obesity is associated with pathological eating behavior/disorders in craniopharyngioma patients. As these disorders are not disease-specific, risk factors for hypothalamic obesity should be the focus of further craniopharyngioma research.

Download Full-text

Eating behaviour and weight problems in long-term survivors of childhood craniopharyngioma – Results of the hit endo trial

Experimental and Clinical Endocrinology & Diabetes ◽

10.1055/s-0035-1547660 ◽

2015 ◽

Vol 122 (03) ◽

Author(s):

A Hoffmann ◽

FP Postma ◽

U Gebhardt ◽

H Müller

Keyword(s):

Eating Behaviour ◽

Weight Problems ◽

Long Term Survivors

Download Full-text

Radiotherapy Is Associated with an Accelerated Risk of Ischemic Stroke in Oral Cavity Cancer Survivors after Primary Surgery

Cancers ◽

10.3390/cancers12030616 ◽

2020 ◽

Vol 12 (3) ◽

pp. 616

Author(s):

Feng-Che Kuan ◽

Kuan-Der Lee ◽

Shiang-Fu Huang ◽

Ping-Tsung Chen ◽

Cih-En Huang ◽

...

Keyword(s):

Ischemic Stroke ◽

Oral Cavity ◽

Cox Regression ◽

Late Complication ◽

Primary Surgery ◽

Oral Cavity Carcinoma ◽

Definitive Surgery ◽

Long Term Survivors ◽

Normal Controls

The number of oral cavity carcinoma (OCC) survivors continues to increase due to advances in definitive surgery and radiation therapy (RT), however the risk of ischemic stroke is unclear in long-term survivors. In this study, survivors are defined as those who survived for >5 years after a diagnosis of OCC. They were matched at a 1:5 ratio with normal controls. Those who received surgery alone versus surgery+RT were also matched at a 1:1 ratio. From 2000 to 2005, 5172 OCC survivors who received surgery alone (n = 3205) or surgery+RT (n = 1967), and 25,860 matched normal controls were analyzed using stratified Cox regression models. Adjusted HRs (aHR) revealed that the surgery+RT group (aHR = 1.68, p < 0.001) had an elevated risk of stroke, but this was not seen in the surgery alone group (aHR = 0.99, p = 0.953). Furthermore, the age at stroke onset was at least 10 years earlier in the surgery+RT group than in the controls. In conclusion, radiotherapy increased the risk of ischemic stroke by 68% and also accelerated the onset of stroke in long-term OCC survivors after primary surgery compared with matched normal controls. Secondary prevention should include stroke as a late complication in OCC survivorship programs.

Download Full-text