scholarly journals Optimization of the magnetic labeling of human neural stem cells and MRI visualization in the hemiparkinsonian rat brain

nano Online ◽  
2016 ◽  
Author(s):  
Milagros Ramos-Gómez ◽  
Emma G Seiz ◽  
Alberto Martínez-Serrano
Keyword(s):  
Stem Cells ◽  
Neural Stem Cells ◽  
Rat Brain ◽  
Human Neural Stem Cells ◽  
Magnetic Labeling

scholarly journals Long-Term Survival of Human Neural Stem Cells in the Ischemic Rat Brain upon Transient Immunosuppression

PLoS ONE ◽  
2010 ◽  
Vol 5 (11) ◽  
pp. e14035 ◽  
Author(s):  
Laura Rota Nodari ◽  
Daniela Ferrari ◽  
Fabrizio Giani ◽  
Mario Bossi ◽  
Virginia Rodriguez-Menendez ◽  
...  
Keyword(s):  
Stem Cells ◽  
Neural Stem Cells ◽  
Rat Brain ◽  
Term Survival ◽  
Long Term Survival ◽  
Human Neural Stem Cells

Human neural stem cells improve sensorimotor deficits in the adult rat brain with experimental focal ischemia

2004 ◽  
Vol 1016 (2) ◽  
pp. 145-153 ◽  
Author(s):  
Kon Chu ◽  
Manho Kim ◽  
Kyung-Il Park ◽  
Sang-Wuk Jeong ◽  
Hee-Kwon Park ◽  
...  
Keyword(s):  
Stem Cells ◽  
Neural Stem Cells ◽  
Rat Brain ◽  
Focal Ischemia ◽  
Human Neural Stem Cells ◽  
Adult Rat ◽  
Sensorimotor Deficits ◽  
Adult Rat Brain

scholarly journals Nanoparticle-mediated transcriptional modification enhances neuronal differentiation of human neural stem cells following transplantation in rat brain

Biomaterials ◽  
2016 ◽  
Vol 84 ◽  
pp. 157-166 ◽  
Author(s):  
Xiaowei Li ◽  
Stephany Y. Tzeng ◽  
Xiaoyan Liu ◽  
Markus Tammia ◽  
Yu-Hao Cheng ◽  
...  
Keyword(s):  
Stem Cells ◽  
Neural Stem Cells ◽  
Rat Brain ◽  
Neuronal Differentiation ◽  
Human Neural Stem Cells

scholarly journals Non-invasive imaging of transplanted human neural stem cells and ECM scaffold remodeling in the stroke-damaged rat brain by 19F- and diffusion-MRI

Biomaterials ◽  
2012 ◽  
Vol 33 (10) ◽  
pp. 2858-2871 ◽  
Author(s):  
Ellen Bible ◽  
Flavio Dell’Acqua ◽  
Bhavana Solanky ◽  
Anthony Balducci ◽  
Peter M. Crapo ◽  
...  
Keyword(s):  
Stem Cells ◽  
Neural Stem Cells ◽  
Rat Brain ◽  
Diffusion Mri ◽  
Human Neural Stem Cells ◽  
Non Invasive ◽  
And Diffusion

Characteristics of human neural stem cells In Vitro and after transplantation into rat brain

2005 ◽  
Vol 139 (1) ◽  
pp. 114-120 ◽  
Author(s):  
M. A. Aleksandrova ◽  
O. V. Podgornyi ◽  
M. V. Marei ◽  
R. A. Poltavtseva ◽  
E. B. Tsitrin ◽  
...  
Keyword(s):  
Stem Cells ◽  
Neural Stem Cells ◽  
Rat Brain ◽  
Human Neural Stem Cells

scholarly journals mRNA-Driven Generation of Transgene-Free Neural Stem Cells from Human Urine-Derived Cells

Cells ◽  
2019 ◽  
Vol 8 (9) ◽  
pp. 1043 ◽  
Author(s):  
Phil Jun Kang ◽  
Daryeon Son ◽  
Tae Hee Ko ◽  
Wonjun Hong ◽  
Wonjin Yun ◽  
...  
Keyword(s):  
Stem Cells ◽  
Neural Stem Cells ◽  
Human Urine ◽  
Neurological Disorders ◽  
Therapeutic Potential ◽  
Embryonic Stem ◽  
Global Gene Expression ◽  
Patient Specific ◽  
Human Neural Stem Cells

Human neural stem cells (NSCs) hold enormous promise for neurological disorders, typically requiring their expandable and differentiable properties for regeneration of damaged neural tissues. Despite the therapeutic potential of induced NSCs (iNSCs), a major challenge for clinical feasibility is the presence of integrated transgenes in the host genome, contributing to the risk for undesired genotoxicity and tumorigenesis. Here, we describe the advanced transgene-free generation of iNSCs from human urine-derived cells (HUCs) by combining a cocktail of defined small molecules with self-replicable mRNA delivery. The established iNSCs were completely transgene-free in their cytosol and genome and further resembled human embryonic stem cell-derived NSCs in the morphology, biological characteristics, global gene expression, and potential to differentiate into functional neurons, astrocytes, and oligodendrocytes. Moreover, iNSC colonies were observed within eight days under optimized conditions, and no teratomas formed in vivo, implying the absence of pluripotent cells. This study proposes an approach to generate transplantable iNSCs that can be broadly applied for neurological disorders in a safe, efficient, and patient-specific manner.

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