Eine Komplementbindungsreaktion zum Nachweis der bei Leukämieviren verschiedener Säuger vorkommenden gemeinsamen antigenen Komponente

1970 ◽  
Vol 25 (9) ◽  
pp. 1029-1036 ◽  
Author(s):  
Werner Schäfer ◽  
Jens Lange ◽  
Liselotte Pister ◽  
Eveline Seifert ◽  
Fernando de Noronha ◽  
...  
Keyword(s):  
Tissue Culture ◽  
Cancer Cells ◽  
Human Cancer ◽  
Leukemia Virus ◽  
Mouse Leukemia ◽  
Human Cancer Cells ◽  
Mouse Leukemia Virus ◽  
Bovine Leukosis

By immunization of a rabbit with purified gs-antigen from mouse leukemia virus (MLV) a potent antiserum (R-gs-serum) was obtained, which reacts specifically with gs-antigen of MLV.In cat leukemia virus (KLV) two types of antigens, probably both group specific, could be demonstrated with anti-KLV-sera by Ouchterlony test. One of these was shown with MLV-sera to be identical with a MLV-gs-antigen component. This antigen occurring in both viruses is called gsinterspecies (interspec.) antigen.R-gs-serum allowed to detect gs-interspec. antigen also by the more sensitive CF-test. [Lispa (leukemia virus interspec. antigen) CF-test]. Preliminary experiments with this test indicated that bovine leukosis as well as human cancer cells can produce an agent in tissue culture which is serologically related to MLV.

Malignant transformation in a tissue culture infected with a mouse leukemia virus

1968 ◽  
Vol 23 (1-2) ◽  
pp. 169-174 ◽  
Author(s):  
J. G. Sinkovics ◽  
F. Gy�rkey ◽  
Glenda F. Groves ◽  
Phyllis Gy�rkey
Keyword(s):  
Tissue Culture ◽  
Malignant Transformation ◽  
Leukemia Virus ◽  
Mouse Leukemia ◽  
Mouse Leukemia Virus

scholarly journals Selective Targeting and Inducible Destruction of Human Cancer Cells by Retroviruses with Envelope Proteins Bearing Short Peptide Ligands

2002 ◽  
Vol 76 (7) ◽  
pp. 3564-3569 ◽  
Author(s):  
Timothy J. Gollan ◽  
Michael R. Green
Keyword(s):  
Cancer Cells ◽  
Human Cancer ◽  
Leukemia Virus ◽  
Peptide Ligands ◽  
Specific Cell ◽  
Kinase Gene ◽  
Short Peptide ◽  
Human Cancer Cell Lines ◽  
Surface Receptors ◽  
Human Cancer Cells

ABSTRACT In the accompanying study, we show how retroviral tropism can be redirected by insertion of short peptide ligands at multiple locations in envelope. Here we use this approach to selectively target and destroy human cancer cells. Many cancer cells overexpress specific cell surface receptors. We have generated Moloney murine leukemia virus (MLV) envelope derivatives bearing short peptide ligands for gastrin-releasing protein (GRP) and human epidermal growth factor receptors. Pseudotyped viruses containing these chimeric envelope derivatives selectively transduce human cancer cell lines that overexpress the cognate receptor. A retrovirus targeting the GRP receptor can deliver the thymidine kinase gene to human melanoma and breast cancer cells, which are killed by the subsequent addition of ganciclovir. Collectively, our results demonstrate that short peptide ligands inserted at appropriate locations in MLV envelope can selectively target retroviruses to human cancer cells and deliver a therapeutically relevant gene.

Indirubin derivatives inhibit SFKs/Stat signaling associated with apoptosis in human cancer cells

Planta Medica ◽  
2008 ◽  
Vol 74 (09) ◽  
Author(s):  
S Nam ◽  
R Buettner ◽  
X Liu ◽  
J Turkson ◽  
D Kim ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Human Cancer ◽  
Human Cancer Cells ◽  
Stat Signaling
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