Zur Reaktivität von C=N-Doppelbindungssystemen, VII. Synthesen von fluoreszierenden pyronokondensierten Heterocyclen / The Reactivity of the C=N-Double Bond Systems, VII. Syntheses of Condensed Pyronoheterocycles

1976 ◽  
Vol 31 (4) ◽  
pp. 514-519 ◽  
Author(s):  
Otto S. Wolfbeis ◽  
Erich Ziegler
Keyword(s):  
Double Bond ◽  
Ethyl Cyanoacetate ◽  
Hydroxy Coumarin ◽  
Combined Action

The combined action of orthoformate and aniline upon 4-hydroxy-coumarin yields anilinomethylene chromon-2,4-dione, which reacts with ethyl cyanoacetate in DMF in the presence of KOH to give the pyronocoumarine (6a). Pyronoquinolones are obtained in a similar way.

scholarly journals Benzotriazol-1-yl-Acetone as a Building Block in Heterocyclic Chemistry: A Route to Benzotriazolylpyridazines, Benzotriazolylphthalazines and Benzotriazolylpyrazolo[5,1-c]-1,2,4-triazines

1999 ◽  
Vol 23 (11) ◽  
pp. 648-649
Author(s):  
Abdul Aziz Al-Naggar ◽  
Mervat Mohammed Abdel-Khalik ◽  
Mohammed Hilmy Elnagdi
Keyword(s):  
Double Bond ◽  
Building Block ◽  
Ethyl Cyanoacetate ◽  
Diazonium Salts ◽  
Heterocyclic Chemistry

Benzotriazolylacetone is coupled with aromatic diazonium salts to yield arylhydrazones, which can be condensed with ethyl cyanoacetate yielding pyridazinones whose reactivity towards activated double bond systems is investigated.

Zur Reaktivität von C=N-Doppelbindungssystemen, XVI [1]. Eine Synthese von 2-Hydroxy-6-oxo-1.6-dihydro-pyridinen / The Reactivity of C=N Double Bond Systems, XVI [1]. Synthesis of 2-Hydroxy-6-oxo-1,6-dihydro-pyridines

1978 ◽  
Vol 33 (12) ◽  
pp. 1550-1553 ◽  
Author(s):  
Erich Ziegler ◽  
Helmut Wipfler ◽  
Andreas Knierzinger ◽  
O. S. Wolfbeis
Keyword(s):  
Double Bond ◽  
Triethyl Orthoformate ◽  
Meldrum's Acid ◽  
Meldrum’S Acid ◽  
Combined Action

The combined action of triethyl orthoformate and aniline upon Meldrum's acid or 5-aza-5-phenyl-1-oxaspiro[5,5]undecan-2,4-diones gives their anilinomethylene derivatives (2, 5), which react with methyleneactive nitriles in dimethylformamide to give substituted 2-hydroxy-6-oxo-1,6-dihydro-pyridines (7) in excellent yields.

Zur Reaktivität von C=N-Doppelbindungssystemen, X Synthesen von kondensierten Heterocyclen. / The Reactivity of C=N-Double Bond Systems, Χ Synthesis of Condensed Heterocycles

1976 ◽  
Vol 31 (11) ◽  
pp. 1519-1525 ◽  
Author(s):  
Otto S. Wolfbeis ◽  
Erich Ziegler
Keyword(s):  
Double Bond ◽  
Combined Action ◽  
Condensed Heterocycles

The combined action of orthoformate and aniline upon cyclohexanedione-1,3 yields anilinomethylene-cyclohexanedione-1,3, which react with cyanoacetate or malodinitrile in DMF in the presence of KOH to give ethyl-1-phenyl-2,5-dioxo-1,2,5,6,7,8-hexahydroquinoline-3-carboxylates (or -carbonitrils)

The Effect of Stress and Warfarin on the Adrenal Gland in Relation to Spontaneous Hemorrhage, as Judged by Measurement of Adrenal Ascorbic Acid and Serum Corticosterone

1971 ◽  
Vol 26 (02) ◽  
pp. 275-288 ◽  
Author(s):  
S Chattopadhyay ◽  
D. D Johnson ◽  
G. J Millar ◽  
L. B Jaques
Keyword(s):  
Ascorbic Acid ◽  
Acid Concentration ◽  
Ascorbic Acid Concentration ◽  
Corticosterone Concentration ◽  
Serum Corticosterone ◽  
Spontaneous Hemorrhage ◽  
Combined Action ◽  
Series Of Experiments ◽  
Pituitary Adrenal Axis

SummaryRats were subjected to the following procedures: No treatment, Stressor (10% NaCl i.p.), Warfarin for 7 days, Stressor followed by Warfarin; and groups were sacrificed at intervals for assessment of spontaneous hemorrhage and of adrenal ascorbic acid concentration. There was no hemorrhage in the no treatment and stressor groups; some hemorrhage in the warfarin group; profound hemorrhage with Warfarin + Stressor. The adrenal ascorbic acid concentration was found to be lower, 8 h and again 5 days after stress, and remained lower in the warfarin + stress animals. Warfarin had no effect on adrenal ascorbic acid level.In another series of experiments in which the stress consisted of an electric current to the cage floor for 6 sec over 15 min, rats were sacrificed daily for determination of serum corticosterone concentration and occurrence of spontaneous hemorrhage. There was a statistically significant increase of serum corticosterone concentration with stress, warfarin and combined warfarin and stress treatments (P< 0.001 for all three variables). There was a significant correlation (r = 0.96 and 0.89, P< 0.01) for serum corticosterone concentration with hemorrhage score and incidence of hemorrhage in stressed rats receiving warfarin, but not in those receiving only warfarin. The results indicate an activation, rather than an exhaustion, of the pituitary-adrenal axis during the combined action of anticoagulant and stress, which results in the development of spontaneous hemorrhage.

THE THYMOLYTIC ACTIVITY OF 6- AND 9-HALOCORTICOIDS AND RELATED STEROIDS

1965 ◽  
Vol 49 (2) ◽  
pp. 262-270 ◽  
Author(s):  
Ralph I. Dorfman ◽  
P. G. Holton ◽  
Fred A. Kind
Keyword(s):  
Double Bond ◽  
Subcutaneous Injection ◽  
Fluocinolone Acetonide ◽  
Relative Potency ◽  
Subcutaneous Route ◽  
Adrenalectomized Rats

ABSTRACT Adrenalectomized rats were used for the determination of the relative potency of various 6- and 9-halo substituted corticoids administered subcutaneously or by gavage using thymus weightas the endpoint. By subcutaneous injection, fluocinolone acetonide was the most active corticoid at 700 times that of cortisol. This compound was also the most active corticoid by the gavage route and was judged to be 570 times as active as the standard cortisol. The introduction of the 16,17-acetonide and 16,17-acetone 21-acetate groups into 17α,21-dihydroxy-9α,11β-dichloropregna-1,4-diene-3,20-dione increased the activity by a factor of 42 and 100, respectively. The introduction of the δ1 double bond into 6α-fluoroprogesterone 16,17-acetonide caused an increase of 10-fold in thymolytic activity assessed by the subcutaneous route

TRIGLYCERIDE COMPOSITION OF SIXTEEN STRAINS OF MARINE DIATOM

2013 ◽  
Vol 5 (1) ◽  
Author(s):  
Lily M.G. Panggabean ◽  
Abdullah Rasyid ◽  
Zarrah Duniani ◽  
Yana Meliana ◽  
Indah Kurniasih
Keyword(s):  
Mass Spectrometry ◽  
Fatty Acid ◽  
Double Bond ◽  
Unsaturated Fatty Acid ◽  
Ion Trap ◽  
Carbon Chain ◽  
Highly Unsaturated Fatty Acid ◽  
Marine Diatom ◽  
Ion Trap Mass Spectrometry ◽  
Spectra Analysis

Trigliceride or triacylglicerol (TAG) composition in crude oil of sixteen strain of marine diatom has been detected by spectra analyses on an Electrospray - Ion Trap – Mass Spectrometry (ESI-IT-MS) HCT Bruker-Daltonic GmbH instrument with AgNO3 used as coordination ionization agent. Biomass samples of each microalga strain were taken from early and late stationary cultures in f/2 enriched seawater and algal oils were extracted according to Bligh and Dyer. Results from spectra analysis showed that P-Pt-P (C16:0-C16:1-C16:0) were distinguished in TAG from diatom strains Chaetoceros sp.1, Chaetoceros sp.2, Thalasiossira sp.1, Thalasiossira sp.2, Thalasiossira sp.3, Navicula sp. 1, Navicula sp. 2, Navicula sp. 3, Navicula sp. 4, Nitzschia sp. 2 and Amphora sp. In contrast, TAGs in Melosira sp. included P-P-P (C16:0-C16:0-C16:0) and P-P-O (C16:0-C16:0-C18:1) were identified. TAGs from Chaetoceros sp. were the most varies among samples, i.e. P-Pt-P (C16:0-C16:1-C16:0), A-P-M (C20:4-C16:0-C14:0), P-Pt-Lt (C16:0-C16:1-C18:3), P-Pt-A (C16:0-C16:1-C20:4), D-P-P (C22:6-C16:0-C16:0), A-Ln-P (C20:4-C18:2-C16:0). Various TAGs were also detected in Nitzschia sp.2, i.e. P-Pt-M (C16:0-C16:1-C14:0), P-Pt-P (C16:0-C16:1-C16:0), P-Pt-S (C16:0-C16:1-C18:0), P-Pt-A (C16:0-C16:1-C20:4). TAGs composition in Skeletonema strains that similar to those in Nitzschia sp.1 has longer carbon, i.e. P-P-O (C16:0-C16:0-C18:1), P-O-O (C16:0-C18:1-C18:1) and O-O-O (C18:1-C18:1-C18:1). TAGs with longer carbon chain and more double bond including highly unsaturated fatty acid C20:4 were increased with culture age in diatoms Chaetoceros sp.1, Chaetoceros sp.2, Thalasiossira sp.2, Navicula sp.1 and Nitzschia sp. 2.Keywords: diatom, TAG, ESI-IT-MS, f/2, early and late stationary

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