Inhibition Of Plant Acetyl-Co A Synthetase By Alkyl-Adenylates
1992 ◽
Vol 47
(11-12)
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pp. 845-850
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Keyword(s):
De Novo
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The plant acetyl-CoA synthetase (ACS) is bound to the plastids and provides acetyl-CoA, the starting substrate for de novo fatty acid biosynthesis in plastids. This enzymic reaction, which consumes ATP and releases AMP, can be inhibited by different alkyladenylates such as ethyl-, isopropyl-, propyl- or allyl-adenylates as is shown here. The inhibition mechanism is competitive with respect to ATP and non-com petitive with respect to acetate. I50-values and the inhibition constants K( (ATP), Ki (acetate) and Kii (acetate) are given. The results suggest that, also in plants, acetyl-adenylate is the endogenous intermediate in the enzymic formation of acetyl-CoA from acetate by acetyl-CoA synthetase
1994 ◽
Vol 49
(7-8)
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pp. 421-426
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1992 ◽
Vol 47
(5-6)
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pp. 382-386
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