Different Effect Of Dgtp On 2'-Deoxyadenosine Metabolism In Mitochondria And Cytosol
1992 ◽
Vol 47
(11-12)
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pp. 893-897
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Keyword(s):
Two enzymes participating in 2′-deoxyadenosine (dAdo) metabolism: dAdo kinase (dAdoK EC 2.7.1.76) and adenosine deaminase (ADA, EC 3.5.4.4) were partially purified from rat liver mitochondria and cytosol and influence of nucleosides and nucleotides on the activity of these enzymes were investigated. Mitochondrial and cytosol dAdoK are separate proteins, while ADA from both subcellular fractions possesses similar physical properties. dGTP, a com petitive inhibitor of mitochondrial dAdoK, inhibits cytosol ADA in a mixed way but activates mitochondrial ADA and cytosol dAdoK. A possible effect of dGTP on dAdo metabolism in mitochondria and cytosol is discussed
Keyword(s):
1990 ◽
Vol 68
(12)
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pp. 1380-1392
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Keyword(s):
Keyword(s):
1971 ◽
Vol 29
◽
pp. 570-571
2016 ◽
Vol 7
(4)
◽
pp. 349-361
Keyword(s):
1988 ◽
Vol 189
(1)
◽
pp. 39-44
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Keyword(s):
1961 ◽
Vol 236
(1)
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pp. 221-224
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1985 ◽
Vol 260
(2)
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pp. 1311-1325
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1971 ◽
Vol 246
(23)
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pp. 7139-7143