Therapeutic potential of melanin-concentrating hormone-1 receptor antagonists for the treatment of obesity

2004 ◽  
Vol 13 (9) ◽  
pp. 1113-1122 ◽  
Author(s):  
Timothy J Kowalski ◽  
Mark D McBriar
Keyword(s):  
Therapeutic Potential ◽  
Receptor Antagonists ◽  
Melanin Concentrating Hormone ◽  
Treatment Of Obesity

New Amide Derivatives as Melanin-concentrating Hormone Receptor 1 Antagonists for the Treatment of Obesity

2011 ◽  
Vol 58 (11) ◽  
pp. 585-591
Author(s):  
Nuria Cirauqui ◽  
Javier Ceras ◽  
Silvia Galiano ◽  
Silvia Pérez-Silanes ◽  
Laura Juanenea ◽  
...  
Keyword(s):  
Hormone Receptor ◽  
Amide Derivatives ◽  
Melanin Concentrating Hormone ◽  
Treatment Of Obesity

Proglucagon-Derived Peptides: Mechanisms of Action and Therapeutic Potential

Physiology ◽  
2005 ◽  
Vol 20 (5) ◽  
pp. 357-365 ◽  
Author(s):  
Elaine M Sinclair ◽  
Daniel J. Drucker
Keyword(s):  
Type 2 Diabetes ◽  
Human Disease ◽  
Clinical Relevance ◽  
Therapeutic Potential ◽  
Mechanisms Of Action ◽  
Receptor Antagonists ◽  
Glucagon Receptor ◽  
Receptor Agonists ◽  
Glucagon Like Peptide

Glucagon is used for the treatment of hypoglycemia, and glucagon receptor antagonists are under development for the treatment of type 2 diabetes. Moreover, glucagon-like peptide (GLP)-1 and GLP-2 receptor agonists appear to be promising therapies for the treatment of type 2 diabetes and intestinal disorders, respectively. This review discusses the physiological, pharmacological, and therapeutic actions of the proglucagon-derived peptides, with an emphasis on clinical relevance of the peptides for the treatment of human disease.

Structure–activity relationships of a novel series of melanin-concentrating hormone (MCH) receptor antagonists

2004 ◽  
Vol 14 (15) ◽  
pp. 4099-4102 ◽  
Author(s):  
Rosa Arienzo ◽  
David E Clark ◽  
Sue Cramp ◽  
Stephen Daly ◽  
Hazel J Dyke ◽  
...  
Keyword(s):  
Receptor Antagonists ◽  
Structure Activity Relationships ◽  
Structure Activity ◽  
Melanin Concentrating Hormone

Synthesis and Evaluation of New Arylsulfonamidomethylcyclohexyl Derivatives as Human Neuropeptide Y Y5 Receptor Antagonists for the Treatment of Obesity.

ChemInform ◽  
2004 ◽  
Vol 35 (30) ◽  
Author(s):  
Antonio Moreno ◽  
Silvia Perez ◽  
Silvia Galiano ◽  
Laura Juanenea ◽  
Oihana Erviti ◽  
...  
Keyword(s):  
Neuropeptide Y ◽  
Receptor Antagonists ◽  
Treatment Of Obesity
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