Calcium-activated potassium channels – a therapeutic target for modulating nitric oxide in cardiovascular disease?

2010 ◽  
Vol 14 (8) ◽  
pp. 825-837 ◽  
Author(s):  
Thomas Dalsgaard ◽  
Christel Kroigaard ◽  
Ulf Simonsen
Keyword(s):  
Nitric Oxide ◽  
Cardiovascular Disease ◽  
Potassium Channels ◽  
Therapeutic Target ◽  
Calcium Activated Potassium Channels

Responses of cerebral arterioles in diabetic rats to activation of ATP-sensitive potassium channels

1993 ◽  
Vol 265 (1) ◽  
pp. H152-H157 ◽  
Author(s):  
W. G. Mayhan ◽  
F. M. Faraci
Keyword(s):  
Nitric Oxide ◽  
Diabetes Mellitus ◽  
Potassium Channels ◽  
Diabetic Rats ◽  
Nonspecific Effect ◽  
Pial Arterioles ◽  
Calcium Activated Potassium Channels ◽  
Cerebral Arterioles

The goal of this study was to determine whether responses of pial arterioles to activation of ATP-sensitive potassium channels are altered during diabetes mellitus. We measured changes in diameter of pial arterioles in vivo in nondiabetic and diabetic rats (streptozotocin; 50–60 mg/kg ip; studied 3–4 mo after streptozotocin) in response to RP52891, an activator of ATP-sensitive potassium channels. RP52891 (1.0 microM) dilated pial arterioles in nondiabetic rats by 16 +/- 1% but constricted pial arterioles in diabetic rats by 2 +/- 2% (means +/- SE; P < 0.05 vs. response in nondiabetic rats). Dilatation of pial arterioles in nondiabetic rats in response to RP52891 was inhibited by glibenclamide (1.0 microM) but was not altered by NG-monomethyl-L-arginine (1.0 microM), apamin (0.1 microM), or charybdotoxin (50 nM). Thus dilatation of pial arterioles in response to RP52891 appears to be due to activation of ATP-sensitive potassium channels and does not involve nitric oxide or calcium-activated potassium channels. To determine whether impaired dilatation of pial arterioles in response to RP52891 in diabetic rats was related to a nonspecific effect of diabetes mellitus on vasodilatation, we measured diameter of pial arterioles in nondiabetic and diabetic rats in response to nitroglycerin. Nitroglycerin (1.0 microM) dilated pial arterioles by 12 +/- 1% in nondiabetic rats and 16 +/- 2% in diabetic rats (P > 0.05). Thus impaired dilatation of pial arterioles in diabetic rats in response to RP52891 also is not related to a nonspecific effect of diabetes mellitus on vasodilatation.(ABSTRACT TRUNCATED AT 250 WORDS)

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